E. Sander Connolly
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View article: Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration
Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration Open
View article: Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel
Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel Open
BACKGROUND AND OBJECTIVES: Despite many publications about cavernous malformations (CMs), controversy remains regarding diagnostic and management strategies. To update evidence-based guidelines for the clinical management of brain and spin…
View article: Low hemoglobin causes hematoma expansion and poor intracerebral hemorrhage outcomes
Low hemoglobin causes hematoma expansion and poor intracerebral hemorrhage outcomes Open
Objectives Although lower hemoglobin levels associate with worse intracerebral hemorrhage (ICH) outcomes, causal drivers for this relationship remain unclear. We investigated the hypothesis that lower hemoglobin relates to increased hemato…
View article: Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome
Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome Open
Background Baseline anemia is associated with poor intracerebral hemorrhage (ICH) outcomes. However, underlying drivers for anemia and whether anemia development after ICH impacts clinical outcomes are unknown. We hypothesized that inflamm…
View article: Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria
Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria Open
Background Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity, but its pathophysiology is poorly characterized. We investigated characteristics of pregnancy‐associated ICH (P‐ICH), compared with ICH in similar aged nonpr…
View article: ABO blood type and thromboembolic complications after intracerebral hemorrhage: An exploratory analysis
ABO blood type and thromboembolic complications after intracerebral hemorrhage: An exploratory analysis Open
View article: Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis
Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis Open
This systematic review, meta-analysis, and novel time course analysis examines microvascular failure in the treatment of acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) and/or thrombolytic administration for stro…
View article: Suboptimal Cerebral Perfusion is Associated with Ischemia After Intracerebral Hemorrhage
Suboptimal Cerebral Perfusion is Associated with Ischemia After Intracerebral Hemorrhage Open
View article: Expansion of stenting indications in the USA
Expansion of stenting indications in the USA Open
View article: Table of Contents
Table of Contents Open
Does the RAPIDO trial suggest a benefit of post-operative chemotherapy after preoperative chemoradiation in rectal cancer?No, it does not.
View article: Injury patterns associated with cognitive motor dissociation
Injury patterns associated with cognitive motor dissociation Open
In unconscious appearing patients with acute brain injury, wilful brain activation to motor commands without behavioural signs of command following, known as cognitive motor dissociation (CMD), is associated with functional recovery. CMD c…
View article: ABO Blood Type and Thromboembolic Complications after Intracerebral Hemorrhage: an exploratory analysis
ABO Blood Type and Thromboembolic Complications after Intracerebral Hemorrhage: an exploratory analysis Open
View article: Role of gC1qR as a modulator of endothelial cell permeability and contributor to post-stroke inflammation and edema formation
Role of gC1qR as a modulator of endothelial cell permeability and contributor to post-stroke inflammation and edema formation Open
Ischemic stroke is a leading cause of death and disability worldwide. A serious risk of acute ischemic stroke (AIS) arises after the stroke event, due to inflammation and edema formation. Inflammation and edema in the brain are mediated by…
View article: Automatic identification of intracranial pressure waveform during external ventricular drainage clamping: segmentation via wavelet analysis
Automatic identification of intracranial pressure waveform during external ventricular drainage clamping: segmentation via wavelet analysis Open
Objective . The objective of this study is to develop and validate a method for automatically identifying segments of intracranial pressure (ICP) waveform data from external ventricular drainage (EVD) recordings during intermittent drainag…
View article: Red Blood Cell Transfusions Are Not Associated With Incident Complications or Poor Outcomes in Patients With Intracerebral Hemorrhage
Red Blood Cell Transfusions Are Not Associated With Incident Complications or Poor Outcomes in Patients With Intracerebral Hemorrhage Open
Background Anemia is associated with poor intracerebral hemorrhage (ICH) outcomes, yet the relationship of red blood cell (RBC) transfusions to ICH complications and functional outcomes remains unclear. We investigated the impact of RBC tr…
View article: A Deep Learning Framework for Deriving Noninvasive Intracranial Pressure Waveforms from Transcranial Doppler
A Deep Learning Framework for Deriving Noninvasive Intracranial Pressure Waveforms from Transcranial Doppler Open
Increased intracranial pressure (ICP) causes disability and mortality in the neurointensive care population. Current methods for monitoring ICP are invasive. We designed a deep learning framework using a domain adversarial neural network t…
View article: Concordance Between Active Partial Thromboplastin Time and Anti-Factor Xa Assays in Neurocritically Ill Patients Receiving Subcutaneous Heparin Prophylaxis
Concordance Between Active Partial Thromboplastin Time and Anti-Factor Xa Assays in Neurocritically Ill Patients Receiving Subcutaneous Heparin Prophylaxis Open
Background Laboratory monitoring is not recommended when subcutaneous unfractionated heparin (SQ-UFH) is administered at prophylactic doses. However, aPTT prolongation and associated hemorrhage has been reported in the neurocritically ill.…
View article: Delirium and Previous Psychiatric History Independently Predict Poststroke Posttraumatic Stress Disorder
Delirium and Previous Psychiatric History Independently Predict Poststroke Posttraumatic Stress Disorder Open
Objectives: Delirium is an acute brain dysfunction that has been correlated with adverse mental health outcomes, such as depression and posttraumatic stress disorder (PTSD). However, delirium has not been studied in relation to mental heal…
View article: Atherosclerosis is a smooth muscle cell-driven tumor-like disease
Atherosclerosis is a smooth muscle cell-driven tumor-like disease Open
Atherosclerosis, the leading cause of cardiovascular disease, is a chronic inflammatory disease involving pathological activation of multiple cell types, such as immunocytes (e.g., macrophage, T cells), smooth muscle cells (SMCs), and endo…
View article: Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients*
Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients* Open
OBJECTIVES: Low hemoglobin concentration impairs clinical hemostasis across several diseases. It is unclear whether hemoglobin impacts laboratory functional coagulation assessments. We evaluated the relationship of hemoglobin concentration…
View article: Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage
Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage Open
Background: Targeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury. Brain tissue oxygenation (PbtO 2 ) can identify i…
View article: Complement C3 inhibition in severe COVID-19 using compstatin AMY-101
Complement C3 inhibition in severe COVID-19 using compstatin AMY-101 Open
Complement C3 activation contributes to COVID-19 pathology, and C3 targeting has emerged as a promising therapeutic strategy. We provide interim data from ITHACA, the first randomized trial evaluating a C3 inhibitor, AMY-101, in severe COV…
View article: Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study
Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study Open
View article: Predicting Shunt Dependency from the Effect of Cerebrospinal Fluid Drainage on Ventricular Size
Predicting Shunt Dependency from the Effect of Cerebrospinal Fluid Drainage on Ventricular Size Open
View article: Editorial. Neuroprotective effectiveness
Editorial. Neuroprotective effectiveness Open
arcía-Pastor and colleagues herein report the results of a small, single-center, prospective, randomized, double-blind, placebo-controlled study of dapsone in patients presenting within 5 days of Fisher grade 3 and 4 aneurysmal subarachnoi…
View article: PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans Open
View article: Correction to: Definition and Prioritization of Data Elements for Cohort Studies and Clinical Trials on Patients with Unruptured Intracranial Aneurysms: Proposal of a Multidisciplinary Research Group
Correction to: Definition and Prioritization of Data Elements for Cohort Studies and Clinical Trials on Patients with Unruptured Intracranial Aneurysms: Proposal of a Multidisciplinary Research Group Open
View article: Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis
Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis Open
View article: Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage Open
Acute platelet transfusion after intracerebral hemorrhage (ICH) given in efforts to reverse antiplatelet medication effects and prevent ongoing bleeding does not appear to improve outcome and may be associated with harm. Although the under…
View article: Dynamic Detection of Delayed Cerebral Ischemia
Dynamic Detection of Delayed Cerebral Ischemia Open
Background and Purpose: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage negatively impacts long-term recovery but is often detected too late to prevent damage. We aim to develop hourly risk scores using routinely c…