David A. Ingram
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View article: Anaplasmosis in Pennsylvania: Clinical Features, Diagnosis, and Outcomes of Patients Diagnosed With <i>Anaplasma phagocytophilum</i> Infection at Hershey Medical Center From 2008 to 2021
Anaplasmosis in Pennsylvania: Clinical Features, Diagnosis, and Outcomes of Patients Diagnosed With <i>Anaplasma phagocytophilum</i> Infection at Hershey Medical Center From 2008 to 2021 Open
Anaplasmosis is an emerging infection in the United States and in particular, Pennsylvania. We highlight the abrupt rise in cases of anaplasmosis in the past decade in the state of Pennsylvania with the hope of increasing clinician awarene…
View article: Optimal Duration of Systemic Corticosteroids in Coronavirus Disease 2019 Treatment: A Systematic Review and Meta-analysis
Optimal Duration of Systemic Corticosteroids in Coronavirus Disease 2019 Treatment: A Systematic Review and Meta-analysis Open
Background Corticosteroids confer a survival benefit in individuals hospitalized with coronavirus disease 2019 (COVID-19) who require oxygen. This meta-analysis seeks to determine the duration of corticosteroids needed to optimize this mor…
View article: 1138. Optimal Duration of Systemic Corticosteroids Use in COVID-19 Treatment: A Meta-analysis
1138. Optimal Duration of Systemic Corticosteroids Use in COVID-19 Treatment: A Meta-analysis Open
Background Corticosteroids confer a survival benefit in hospitalized COVID-19 patients requiring oxygen, but optimal treatment duration remains uncertain. The goal of this meta-analysis is to determine the optimal duration of corticosteroi…
View article: Rise in Babesiosis Cases, Pennsylvania, USA, 2005–2018
Rise in Babesiosis Cases, Pennsylvania, USA, 2005–2018 Open
Babesiosis is an emerging infection in the state of Pennsylvania, and clinicians need to be made aware of its clinical manifestations as well as the risk factors associated with severe disease. Before 2010, our tertiary academic center in …
View article: Early administration of imatinib mesylate reduces plexiform neurofibroma tumor burden with durable results after drug discontinuation in a mouse model of neurofibromatosis type 1
Early administration of imatinib mesylate reduces plexiform neurofibroma tumor burden with durable results after drug discontinuation in a mouse model of neurofibromatosis type 1 Open
Background Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by plexiform neurofibromas (pNF), which are thought to be congenital tumors that arise in utero and enlarge throughout life. Genetic studies in murine mod…
View article: Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization
Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization Open
These data suggest that neurofibromin expression is essential for controlling endothelial cell proliferation and retinal neovascularization and therapies targeting neurofibromin-deficient EC may be beneficial.
View article: Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization
Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization Open
Purpose:
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\nNeurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dys…
View article: Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants
Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants Open
We conclude that maternal smoking and hypertension increase the odds for developing BPD after preterm birth, and that maternal smoking is strongly associated with increased odds for late respiratory morbidities during early childhood. Thes…
View article: <i>Nf1</i><sup>+/−</sup>monocytes/macrophages induce neointima formation via CCR2 activation
<i>Nf1</i><sup>+/−</sup>monocytes/macrophages induce neointima formation via CCR2 activation Open
Persons with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosis. Mutations in the NF1 gene result in decreased expression of neurofibromin, a negative regulator of p21(Ras), and increases Ras si…