J R Salisbury
YOU?
Author Swipe
View article: A new screening framework to support the identification of exogenous particles and suspect microplastics in situ in pathological tissue samples
A new screening framework to support the identification of exogenous particles and suspect microplastics in situ in pathological tissue samples Open
Medical Research Council.
View article: A Gradient-Optimized TSK Fuzzy Framework for Explainable Phishing Detection
A Gradient-Optimized TSK Fuzzy Framework for Explainable Phishing Detection Open
Phishing attacks represent an increasingly sophisticated and pervasive threat to individuals and organizations, causing significant financial losses, identity theft, and severe damage to institutional reputations. Existing phishing detecti…
View article: P1211: TUMOR-ACTIVATED LYMPH NODE FIBROBLASTS SUPPRESS T CELL FUNCTION IN DIFFUSE LARGE B CELL LYMPHOMA
P1211: TUMOR-ACTIVATED LYMPH NODE FIBROBLASTS SUPPRESS T CELL FUNCTION IN DIFFUSE LARGE B CELL LYMPHOMA Open
Topic: 20. Lymphoma Biology & Translational Research Background: Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of lymph node (LN) fibroblast and tumor-infiltrating lymp…
View article: Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma Open
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of lymph node (LN) fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within the tumor microenvironment (TME). …
View article: A patient with widespread firm nontender nodules
A patient with widespread firm nontender nodules Open
A 63-year-old man with a history of chronic myelomonocytic leukemia (CMML) presented with a 2 month history of widespread nonpainful skin lesions. Otherwise he felt well and reported no systemic symptoms. On examination, there were nontend…
View article: Acute hepatic failure in trimethoprim-induced drug rash with eosinophilia and systemic symptoms (DRESS)
Acute hepatic failure in trimethoprim-induced drug rash with eosinophilia and systemic symptoms (DRESS) Open
In this paper, we describe four cases of drug rash with eosinophilia and systemic symptoms (DRESS) caused by trimethoprim administered for the treatment of acne. All cases were complicated by acute hepatic failure.
View article: Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation Open
Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation…
View article: Widespread myeloid sarcomas in a patient in morphological remission in the bone marrow
Widespread myeloid sarcomas in a patient in morphological remission in the bone marrow Open
A 60-year-old woman previously diagnosed with acute myeloid leukaemia (AML) with fibrosis (normal karyotype, NPM1-mutated, FLT3-ITD negative, TET2 mutations (two variants) and SRSF2 mutations detected on our myeloid gene panel) presented w…
View article: Trimethoprim‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with reactivation of human herpes virus‐6 (HHV‐6) leading to acute liver failure
Trimethoprim‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with reactivation of human herpes virus‐6 (HHV‐6) leading to acute liver failure Open
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome can have insidious symptoms which may lead to acute liver failure and death. Prompt recognition, stopping offending drug, and initiating corticosteroid are the mainstay…
View article: Giant multinucleated plasma cells in relapsed plasma cell myeloma
Giant multinucleated plasma cells in relapsed plasma cell myeloma Open
A 47-year-old woman was diagnosed with plasma cell myeloma in 2018, received first-line induction chemotherapy, and made a partial response. She then received two cycles of DT-PACE chemotherapy. Her paraprotein levels remained static and a…
View article: The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells
The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells Open
CD4+ T-follicular helper cells are essential for the survival, proliferation, and differentiation of germinal center B cells and have been implicated in the pathogenesis of follicular lymphoma (FL). To further define the role of these cell…
View article: PS1304 FOLLICULAR HELPER T‐CELLS FORM MUTUALLY SUPPORTIVE INTERACTIONS WITH FOLLICULAR LYMPHOMA B‐CELLS THAT MAY SUPPORT TUMOUR GROWTH
PS1304 FOLLICULAR HELPER T‐CELLS FORM MUTUALLY SUPPORTIVE INTERACTIONS WITH FOLLICULAR LYMPHOMA B‐CELLS THAT MAY SUPPORT TUMOUR GROWTH Open
Background: Follicular lymphoma (FL) is a germinal centre (GC) B‐cell neoplasm that is dependent on interactions with its non‐malignant tumour microenvironment (TME). Follicular helper T‐cells (Tfh) play a pivotal role in supporting health…