William J. Huang
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View article: 592. ANTIDEPRESSANT USE AND ANTIBIOTICS TREATMENT FAILURE
592. ANTIDEPRESSANT USE AND ANTIBIOTICS TREATMENT FAILURE Open
Background Antidepressants may induce antibiotic resistance, yet their impact on antibiotic treatment outcomes in clinical settings remains unexplored. This study investigates the association between antidepressant use and antibiotic treat…
View article: 252. ARE PERSISTENT SOMATIC SYMPTOMS A TRANS-DIAGNOSTIC CONCEPT? A CLUSTER ANALYSIS
252. ARE PERSISTENT SOMATIC SYMPTOMS A TRANS-DIAGNOSTIC CONCEPT? A CLUSTER ANALYSIS Open
Background Psychiatry and other medical specialties have developed various diagnostic constructs related to persistent somatic symptoms (PSS). The risk factors and mechanisms underlying these diagnoses may share trans-diagnostic commonalit…
View article: Associations between Breast Reconstruction Surgery vs. Mastectomy without Reconstruction on Postsurgical Radiation Treatment Modalities: a 2004-2018 NCDB Study
Associations between Breast Reconstruction Surgery vs. Mastectomy without Reconstruction on Postsurgical Radiation Treatment Modalities: a 2004-2018 NCDB Study Open
Background This study compares associations between breast reconstruction surgery (BRS) and types of postmastectomy radiation treatment modalities for breast cancer. Methods Utilizing the NCDB Breast participant use file (PUF) from 2004–20…
View article: Fe-S cluster deficiency drives small colony variant formation in persistent infections
Fe-S cluster deficiency drives small colony variant formation in persistent infections Open
sufB is a novel genetic determinant of stable SCV formation through Fe-S cluster deficiency, driving metabolic shifts that enhance immune evasion and chronic infection. Our findings highlight antibiotic stewardship and suggest potential th…
View article: Deletion of <i>RAP1</i> affects iron homeostasis, azole resistance, and virulence in <i>Candida albicans</i>
Deletion of <i>RAP1</i> affects iron homeostasis, azole resistance, and virulence in <i>Candida albicans</i> Open
Rap1 is a DNA-binding protein conserved from yeast to mammals for its role in telomeric maintenance. Here, to explore additional functions of Candida albicans Rap1, we performed RNA sequencing analysis. Experimental validations further sho…
View article: Clinical outcomes of round spermatid injection vs intracytoplasmic sperm injection: The role of hormonal pretreatment for nonobstructive azoospermia
Clinical outcomes of round spermatid injection vs intracytoplasmic sperm injection: The role of hormonal pretreatment for nonobstructive azoospermia Open
Background: Round spermatid injection (ROSI) into oocytes offers men with nonobstructive azoospermia (NOA) the opportunity to have biological offspring in cases where mature spermatozoa are not detected. However, the clinical outcomes of R…
View article: 101 - A Novel Treatment for Female Underactive Bladder with Chronic Urine Retention: Combining Transvaginal Ultrasound- Guided Botulinum Toxin A Injection and Transurethral Bladder Neck Incision
101 - A Novel Treatment for Female Underactive Bladder with Chronic Urine Retention: Combining Transvaginal Ultrasound- Guided Botulinum Toxin A Injection and Transurethral Bladder Neck Incision Open
View article: Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer
Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer Open
Objective To quantify the oncological risks of bladder‐sparing therapy (BST) in patients with Bacillus Calmette–Guérin (BCG)‐unresponsive non‐muscle‐invasive bladder cancer (NMIBC) compared to upfront radical cystectomy (RC). Patients and …
View article: Enhancing the autologous fascial sling procedure: A novel fixation method for treating stress urinary incontinence in female patients
Enhancing the autologous fascial sling procedure: A novel fixation method for treating stress urinary incontinence in female patients Open
Background: Synthetic mid-urethral sling surgery has long been the standard surgical treatment for stress urinary incontinence (SUI) worldwide. Using an autologous fascial sling is an alternative to reduce adverse events. We evaluated the …
View article: Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry
Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry Open
Urinary metabolomic profiles with baseline clinical factors may accurately predict sPC in men with elevated risk before biopsy.
View article: Surgery for Obstructive Azoospermia
Surgery for Obstructive Azoospermia Open
Microsurgical technique in male infertility has progressed significantly since the introduction of intracytoplasmic sperm infection (ICSI) 30 years ago. The searching of sperm available for ICSI becomes the main tasks for reproductive andr…
View article: Editorial
Editorial Open
In this issue of Urological Science, we have included several interesting publications. Using genetic analysis techniques to confirm the origin of urothelial carcinoma (UC) on the allograft ureter, Sheu et al. reported an unusual case of U…
View article: Effects of different combinations of radical nephroureterectomy and bladder cuff excision procedures for upper tract urothelial carcinoma on bladder recurrence
Effects of different combinations of radical nephroureterectomy and bladder cuff excision procedures for upper tract urothelial carcinoma on bladder recurrence Open
For patients with UTUC, MIS RNU with open BCE is associated with a higher risk of IVR than open RNU with open BCE and MIS RNU with intracorporeal BCE.
View article: Proteomic Analysis of Testicular Interstitial Fluid in Men with Azoospermia
Proteomic Analysis of Testicular Interstitial Fluid in Men with Azoospermia Open
View article: Prediction of microdissection testicular sperm extraction outcomes of azoospermic patients post-chemotherapy using cyclophosphamide equivalent dose
Prediction of microdissection testicular sperm extraction outcomes of azoospermic patients post-chemotherapy using cyclophosphamide equivalent dose Open
View article: Treatment outcomes of radium-223 in patients with metastatic castration-resistant prostate cancer: An experience before National Health Insurance reimbursement in Taiwan
Treatment outcomes of radium-223 in patients with metastatic castration-resistant prostate cancer: An experience before National Health Insurance reimbursement in Taiwan Open
Background: Radium-223 (Ra-223), an α–particle-emitting isotope, inhibits bony metastases and prevents patients from skeletal-related events in metastatic castration-resistant prostate cancer (mCRPC). We retrospectively reviewed the treatm…
View article: Comparison of stone-free rate between percutaneous nephrolithotomy and retrograde intrarenal surgery
Comparison of stone-free rate between percutaneous nephrolithotomy and retrograde intrarenal surgery Open
Background: The management of urolithiasis in the kidney has been drastically changed in the era of endourology, mainly consisting of three surgical procedures: extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PC…
View article: Risk factors for hemorrhagic complications following robotic-assisted partial nephrectomy
Risk factors for hemorrhagic complications following robotic-assisted partial nephrectomy Open
Background: The aim of this study was to analyze the risk factors for hemorrhagic complications in patients who underwent robotic-assisted partial nephrectomy. Methods: We retrospectively reviewed the records of 260 patients who underwent …
View article: Consensus of Experts on the Treatment of Sexual Dysfunction after Surgery for Prostate Cancer in Taiwan
Consensus of Experts on the Treatment of Sexual Dysfunction after Surgery for Prostate Cancer in Taiwan Open
According to the Taiwan Cancer Report, in 2018, prostate cancer was one of the top five cancers reported in men. Each year, many patients with prostate cancer undergo radical prostatectomy (RP) therapy. One of the most common RP complicati…
View article: REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy.
REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy. Open
The association between REST reduction and the development of neuroendocrine prostate cancer (NEPC), a novel drug-resistant and lethal variant of castration-resistant prostate cancer (CRPC), is well established. To better understand the me…
View article: Single-cell analysis of castration-resistant prostate cancers to identify potential biomarkers for diagnosis and prognosis of neuroendocrine prostate cancer.
Single-cell analysis of castration-resistant prostate cancers to identify potential biomarkers for diagnosis and prognosis of neuroendocrine prostate cancer. Open
The high heterogeneity and low percentage of neuroendocrine cells in prostate cancer limit the utility of traditional bulk RNA sequencing and even single-cell RNA sequencing to find better biomarkers for early diagnosis and stratification.…
View article: Whole ureter replacement with Yang–Monti principle: successful treatment of challenging conditions
Whole ureter replacement with Yang–Monti principle: successful treatment of challenging conditions Open
View article: Reply to “The impact of nerve sparing robotic-assisted radical prostatectomy on positive surgical margins: Uncertainty”
Reply to “The impact of nerve sparing robotic-assisted radical prostatectomy on positive surgical margins: Uncertainty” Open
Dear Editor, We thank Dr. Yiu-Tai Li and Wen-Hsun Chang1 for the valuable comments and questions on our study named "Effects of nerve-sparing procedures on surgical margins after robot-assisted radical prostatectomy: a single center cohort…
View article: Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial Carcinoma
Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial Carcinoma Open
Cancers of the urinary tract are one of the most common malignancies worldwide, causing high morbidity and mortality, and representing a social burden. Upper tract urothelial carcinoma (UTUC) accounts for 5–10% of urinary tract cancers, an…
View article: The impact of low-intensity extracorporeal shock waves on testicular spermatogenesis demonstrated in a rat model
The impact of low-intensity extracorporeal shock waves on testicular spermatogenesis demonstrated in a rat model Open
Background: In rodent models, low-intensity extracorporeal shock wave therapy has been shown to negatively impact semen concentration after treatment on the penis, implying that the reproductive system in close proximity may be indirectly …
View article: The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion
The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion Open
View article: Effects of nerve-sparing procedures on surgical margins after robot-assisted radical prostatectomy
Effects of nerve-sparing procedures on surgical margins after robot-assisted radical prostatectomy Open
Background: Nerve-sparing (NS) techniques could potentially increase positive surgical margins after robot-assisted radical prostatectomy (RARP). Nevertheless, the available studies have revealed ambiguous results among distinct groups. Th…
View article: A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancer
A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancer Open
Background Lineage plasticity is recognized as a treatment-induced resistance mechanism in prostate cancer (PCa) and contributes to the development of neuroendocrine prostate cancer (NEPC), a lethal variant of castration-resistant prostate…
View article: The EXPANDER-1 trial: introduction of the novel Urocross™ Expander System for treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH)
The EXPANDER-1 trial: introduction of the novel Urocross™ Expander System for treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) Open
Purpose To demonstrate the safety and feasibility of the Urocross Expander System (formerly branded as XFLO Expander System), an implantable nitinol tissue expander to trea t patients with lower urinary tract symptoms (LUTS) due to benign …
View article: Efficacy evaluation of Chinese herbal medicine, VGH-BPH1, for patients with benign prostatic hyperplasia: A randomized, double-blind, placebo-controlled, and crossover study
Efficacy evaluation of Chinese herbal medicine, VGH-BPH1, for patients with benign prostatic hyperplasia: A randomized, double-blind, placebo-controlled, and crossover study Open
Background: Benign prostatic hyperplasia (BPH) can affect quality of life and cause various complications. Previous studies have suggested that Chinese herbal medicine can alleviate symptoms in patients with BPH. This study aimed to invest…