Jie Bai
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View article: Incidence, risk factors, and survival impact of secondary myelofibrosis in patients with myeloproliferative neoplasms in the real world: A nested case-control study
Incidence, risk factors, and survival impact of secondary myelofibrosis in patients with myeloproliferative neoplasms in the real world: A nested case-control study Open
Myeloproliferative neoplasms (MPN) are a group of diseases characterized by clonal proliferation of hematopoietic stem cells in the bone marrow, mainly including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibr…
View article: Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis
Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis Open
Myelodysplastic syndromes/tumors (MDS) are a highly heterogeneous group of myeloid malignancies. It has been reported that 1.38%~20% of MDS patients were accompanied by T cell large granulosa lymphocyte proliferation (LGLP) at the initial …
View article: Global burden of myocarditis in adolescents and young adults, 1990–2019
Global burden of myocarditis in adolescents and young adults, 1990–2019 Open
While the total number of cases has grown globally in the past three-decades, the incidence rate of myocarditis has declined, with the burden disproportionately affecting males and middle-SDI populations, which highlights the need for targ…
View article: Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype
Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype Open
BACKGROUND Gut microbiota dysbiosis plays a central role in the pathogenesis of functional constipation (FC), but clinical treatment has shown uneven efficacy through methods of regulating intestinal flora. Most existing studies have conce…
View article: TET2 mutations in myeloproliferative neoplasms: potential mediation of atrial fibrillation by interleukin-1β and impact on stroke risk in clinical cohorts
TET2 mutations in myeloproliferative neoplasms: potential mediation of atrial fibrillation by interleukin-1β and impact on stroke risk in clinical cohorts Open
TET2 mutations increase the risk of AF, which may be associated with the IL-1β-mediated inflammatory pathway. AF serves as a critical intermediary for CHIP-associated ischemic stroke. Integrating TET2 status into AF surveillance and antico…
View article: Development and validation of a frailty assessment-based competing risk model for predicting cancer-specific survival in elderly patients with gastric cancer: a dual-center cohort study
Development and validation of a frailty assessment-based competing risk model for predicting cancer-specific survival in elderly patients with gastric cancer: a dual-center cohort study Open
Frailty serves as a critical determinant of clinical outcomes in elderly cancer patients. Nevertheless, there remains a paucity of rigorously validated prognostic tools that account for frailty heterogeneity in older adults with gastric …
View article: Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study)
Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study) Open
This trial was supported by grants from the CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-007), Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0500803), National Natural Science Founda…
View article: Incidence, Outcomes and Risk Factors for Atrial Fibrillation in Patients With <i>JAK2<sup>V617F</sup></i>‐Positive Myeloproliferative Neoplasms
Incidence, Outcomes and Risk Factors for Atrial Fibrillation in Patients With <i>JAK2<sup>V617F</sup></i>‐Positive Myeloproliferative Neoplasms Open
Background The incidence, outcomes and risk factors for AF in the JAK2 V617F ‐positive MPN patients are still unknown. Methods The clinical profiles of patients with JAK2 V617F ‐positive MPN were retrospectively analyzed. Multivariable Cox…
View article: Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity
Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity Open
These findings indicate that procyanidin sustains elevated cGMP levels within cells by targeting PDE5A, thereby exhibiting therapeutic efficacy in improving ICP. Procyanidin emerges as a promising PDE5I for treating ED and potentially othe…
View article: Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota
Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota Open
Adequate sleep is of paramount importance for relieving stress and restoring mental vigor. However, the adverse physiological and pathological responses resulting from sleep insufficiency or sleep deprivation (SD) are becoming increasingly…
View article: Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes
Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes Open
Importance Few of the available therapies for type 2 diabetes (T2D) comprehensively address disease burden beyond glycemic control. Examining whether berberine ursodeoxycholate (HTD1801), a first-in-class gut-liver anti-inflammatory metabo…
View article: TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy
TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy Open
Extrahepatic cholangiocarcinoma (ECCA) is a malignant tumor. The precise role of T-cell immunoreceptor with Ig and ITIM domains (TIGIT), an emerging immunosuppressive receptor, in ECCA, and its impact on CD8+ T cell exhaustion (Tex) remain…
View article: Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in Townes SCD Mouse Model
Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in Townes SCD Mouse Model Open
Background Sickle cell disease (SCD) is a life-threatening genetic condition arising from a point mutation in β-globin gene that causes hemoglobin polymerization, vaso-occlusive sickling of RBCs, and hemolytic anemia. Hereditary persistenc…
View article: Hematopoietic <i> <i>JAK2</i> <i>V617F</i> </i> Mutation Increases Risk for Atrial Fibrillation
Hematopoietic <i> <i>JAK2</i> <i>V617F</i> </i> Mutation Increases Risk for Atrial Fibrillation Open
Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, is associated with increased risk of both hematological malignancies and cardiovascular diseases (Schuermans A, et al. Eur Heart J, 2024). TET2, AS…
View article: Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in a Mouse MDS Model of an Inducible Mutant c-Myc Knock-in
Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in a Mouse MDS Model of an Inducible Mutant c-Myc Knock-in Open
Background Myelodysplastic syndromes (MDS) are a group of diseases of hematopoietic stem cells (HSCs) that occur primarily in the aging population either de novo or secondarily following therapy for unrelated cancers. Among the pan-cytopen…
View article: Optimized Recombinant Human Thrombopoietin(rhTPO) Regimen Versus Eltrombopag for Pre-Treated Patients with Primary Immune Thrombocytopenia: Interim Results from a Prospective, Multicenter, Randomized Trial (TE-ITP study)
Optimized Recombinant Human Thrombopoietin(rhTPO) Regimen Versus Eltrombopag for Pre-Treated Patients with Primary Immune Thrombocytopenia: Interim Results from a Prospective, Multicenter, Randomized Trial (TE-ITP study) Open
Introduction: Recombinant human thrombopoietin (rhTPO), a full-length and glycosylated TPO that is highly similar to endogenous thrombopoietin, has been approved by the China State Food and Drug Administration as a second-line treatment op…
View article: Levels of 91 circulating inflammatory proteins and risk of non-melanoma skin cancer:A two-sample Mendelian randomization study
Levels of 91 circulating inflammatory proteins and risk of non-melanoma skin cancer:A two-sample Mendelian randomization study Open
Background Non-Melanoma Skin Cancer (NMSC) is one of the most common human malignancies with a high incidence rate, posing a heavy economic burden on the global healthcare system. Methods We utilized single nucleotide polymorphisms (SNPs) …
View article: Clinical laboratory characteristics and gene mutation spectrum of <i>Ph</i>‐negative <scp>MPN</scp> patients with atypical variants of <i>JAK2</i>, <i>MPL</i>, or <i>CALR</i>
Clinical laboratory characteristics and gene mutation spectrum of <i>Ph</i>‐negative <span>MPN</span> patients with atypical variants of <i>JAK2</i>, <i>MPL</i>, or <i>CALR</i> Open
Objective To evaluate the incidence, clinical laboratory characteristics, and gene mutation spectrum of Ph ‐negative MPN patients with atypical variants of JAK2 , MPL , or CALR . Methods We collected a total of 359 Ph ‐negative MPN patient…
View article: A randomized, double‐blind, placebo controlled, phase 3 trial to evaluate the efficacy and safety of cetagliptin added to ongoing metformin therapy in patients with uncontrolled type 2 diabetes with metformin monotherapy
A randomized, double‐blind, placebo controlled, phase 3 trial to evaluate the efficacy and safety of cetagliptin added to ongoing metformin therapy in patients with uncontrolled type 2 diabetes with metformin monotherapy Open
Aim This trial was designed to assess the efficacy and safety of cetagliptin added to metformin in Chinese patients with type 2 diabetes who had inadequate glycaemic control with metformin monotherapy. Methods In total, 446 patients with t…
View article: Incidence and risk factors for second malignancies among patients with myeloproliferative neoplasms
Incidence and risk factors for second malignancies among patients with myeloproliferative neoplasms Open
Objective The clinical characteristics and survival of patients with myeloproliferative neoplasms (MPNs) with secondary cancer were analyzed to explore the possible risk factors for secondary cancer in MPN patients. Methods The clinical ch…
View article: Development and validation of a multiple factor-based prognostic score system of thrombosis in polycythemia vera (MFPS-PV)
Development and validation of a multiple factor-based prognostic score system of thrombosis in polycythemia vera (MFPS-PV) Open
Thrombosis is an important cause of death in patients with polycythemia vera (PV). This study aimed to develop and validate a multiple factor-based prediction model of thrombosis and to propose risk-adapted treatment strategies for the 201…
View article: NRIP1 aggravates lung injury caused by Pseudomonas aeruginosa in mice by increasing PIAS1 ubiquitination
NRIP1 aggravates lung injury caused by Pseudomonas aeruginosa in mice by increasing PIAS1 ubiquitination Open
Recently, evidence has shown that nuclear receptor interacting protein 1 (NRIP1) is involved in acute lung injury (ALI) progression, but the specific mechanism remains unclear. Pseudomonas aeruginosa (PA)-treated TC-1 cells were transfecte…