Ju‐Hee Oh
YOU?
Author Swipe
View article: Biomarker-Driven Optimization of Saponin Therapy in MASLD: From Mouse Models to Human Liver Organoids
Biomarker-Driven Optimization of Saponin Therapy in MASLD: From Mouse Models to Human Liver Organoids Open
(1) Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by liver damage similar to alcoholic fatty liver disease, including triglyceride infiltration of hepatocytes, regardless of alcohol consumpti…
View article: The impact of therapeutic radiation on drug distribution across the blood-brain barrier in normal mouse brain and orthotopic glioblastoma tumors
The impact of therapeutic radiation on drug distribution across the blood-brain barrier in normal mouse brain and orthotopic glioblastoma tumors Open
Background Most oncology therapeutics have limited distribution into the brain, and developing strategies to overcome this limitation would be clinically impactful. While therapeutic radiation is often cited as a strategy to accomplish thi…
View article: A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests
A Sequential Ultrafiltration Method to Enhance the Accuracy and Throughput in Plasma Protein Binding Tests Open
Objectives: Ultrafiltration (UF) is widely accepted as a method for assessing the plasma protein binding (PPB) of drugs. However, it is vulnerable to non-specific binding (NSB) to the device, which can result in inaccuracies. This study pr…
View article: Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress
Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress Open
Summary / Abstract To maintain lineage-specific functions, cells must acquire and allocate nutrients across diverse cellular processes, even in metabolically-dysregulated environments. The mechanisms allowing CD8+ T cells to maintain immun…
View article: Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease <i>via</i> necroptosis-independent pathway
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease <i>via</i> necroptosis-independent pathway Open
BACKGROUND Mixed lineage kinase domain-like protein (MLKL) serves as a critical mediator in necroptosis, a form of regulated cell death linked to various liver diseases. This study aims to specifically investigate the role of MLKL’s adenos…
View article: Ticagrelor, but Not Clopidogrel, Attenuates Hepatic Steatosis in a Model of Metabolic Dysfunction-Associated Steatotic Liver Disease
Ticagrelor, but Not Clopidogrel, Attenuates Hepatic Steatosis in a Model of Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background: Previous studies have suggested that platelets are associated with inflammation and steatosis and may play an important role in liver health. Therefore, we evaluated whether antiplatelet agents can improve metabolic disorder-re…
View article: DDIT4L regulates mitochondrial and innate immune activities in early life
DDIT4L regulates mitochondrial and innate immune activities in early life Open
Pattern recognition receptor responses are profoundly attenuated before the third trimester of gestation in the relatively low-oxygen human fetal environment. However, the mechanisms regulating these responses are uncharacterized. Herein, …
View article: Novel Inhibitor of Mixed-Lineage Kinase Domain-Like Protein: The Antifibrotic Effects of a Necroptosis Antagonist
Novel Inhibitor of Mixed-Lineage Kinase Domain-Like Protein: The Antifibrotic Effects of a Necroptosis Antagonist Open
The pseudokinase mixed-lineage kinase domain-like protein plays a crucial role in programmed cell death via necroptosis. We developed a novel mixed-lineage kinase domain-like inhibitor, P28, which demonstrated potent necroptosis inhibition…
View article: Reversible Splenial Lesion Syndrome Associated with Encephalitis/Encephalopathy Improved with Short-Term Steroid Treatment
Reversible Splenial Lesion Syndrome Associated with Encephalitis/Encephalopathy Improved with Short-Term Steroid Treatment Open
Reversible splenial lesion syndrome (RESLES) is a complex clinicoradiological entity that has been reported to occur secondary to several disorders, including acute encephalitis/encephalopathy. On magnetic resonance imaging, it presents as…
View article: Mechanical Properties and Microstructural Evolutions of High-Pressure Torsion-Processed Al7068 Alloy
Mechanical Properties and Microstructural Evolutions of High-Pressure Torsion-Processed Al7068 Alloy Open
The combination of severe plastic deformation, deformational heat, and frictional heat generated during the high-pressure torsion process has a great effect on microstructural evolutions, including grain refinement, dynamic recrystallizati…
View article: Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time
Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time Open
Background H3K27-altered diffuse midline glioma (DMG) is the deadliest pediatric brain tumor; despite intensive research efforts, every clinical trial to date has failed. Is this because we are choosing the wrong drugs? Or are drug deliver…
View article: Preclinical investigation of patient-derived cervical cancer organoids for precision medicine
Preclinical investigation of patient-derived cervical cancer organoids for precision medicine Open
Our results showed that patient-derived cervical cancer organoids can be used as a platform for drug and radiation sensitivity testing. These findings suggest that patient-derived cervical cancer organoids could be used as a personalized m…
View article: WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models Open
Background Although the epidermal growth factor receptor (EGFR) is a frequent oncogenic driver in glioblastoma (GBM), efforts to therapeutically target this protein have been largely unsuccessful. The present preclinical study evaluated th…
View article: Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study
Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study Open
PurposeWe evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM. M…
View article: Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease
Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease Open
Background & Aims : Though obeticholic acid (OCA) is a promising drug for non-alcoholic fatty liver disease (NAFLD), the response rate of OCA is limited. This study aimed to develop a biomarker to optimize OCA treatment for NAFLD. Methods …
View article: DDEL-05. PHARMACOKINETICS AND CNS DISTRIBUTION OF A NOVEL ATM INHIBITOR, WSD0628, FOR THE TREATMENT OF BRAIN TUMORS
DDEL-05. PHARMACOKINETICS AND CNS DISTRIBUTION OF A NOVEL ATM INHIBITOR, WSD0628, FOR THE TREATMENT OF BRAIN TUMORS Open
The treatment of brain tumors using chemo- and radio-sensitizers may be limited by a lack of effective drug delivery. Radiation and some cytotoxic therapies induce DNA damage, and DNA damage response (DDR) pathways modulate resistance to e…
View article: Peripheral blood mononuclear cell mitochondrial copy number and adenosine triphosphate inhibition test in NAFLD
Peripheral blood mononuclear cell mitochondrial copy number and adenosine triphosphate inhibition test in NAFLD Open
Background and aim Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. This study aims to develop biomarkers for assessing mitochondrial dysfunction in patients with NAFLD. Methods Mitochondrion-associat…
View article: Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease
Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease Open
Hepatocyte nuclear factor 4 alpha (HNF4α) is a key master transcriptional factor for hepatic fat and bile acid metabolic pathways. We aimed to investigate the role of HNF4α in non-alcoholic fatty liver disease (NAFLD). The role of HNF4α wa…
View article: Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series
Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series Open
Temporal lobe epilepsy (TLE) is a network disorder of the brain. Network disorders predominately involve dysregulation of hippocampal function caused by neuronal hyperexcitability. However, the relationship between the macro- and microscop…
View article: Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model
Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model Open
Cholecystectomy did not increase the incidence of NAFLD in standard diet-fed mice. Additionally, NAFLD incidence was not significantly different between the HF diet-fed sham and cholecystectomy groups. Furthermore, the histological paramet…