Ju Hee Ryu
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View article: Fluorescence-guided tumor resection with a cathepsin B-activatable, EGFR-targeted probe and a dual-mode surgical exoscope
Fluorescence-guided tumor resection with a cathepsin B-activatable, EGFR-targeted probe and a dual-mode surgical exoscope Open
Fluorescence-guided surgery enhances surgical precision by enabling real-time tumor visualization. Here, we developed a cathepsin B-activatable imaging probe conjugated to the EGFR-targeting antibody cetuximab (Cetux-CB probe) for fluoresc…
View article: Statin-dye conjugates for selective targeting of <i>KRAS</i> mutant cancer cells
Statin-dye conjugates for selective targeting of <i>KRAS</i> mutant cancer cells Open
Over 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations ( KRAS MUT ), for which current treatment options are limited. Statins, commonly used to lower cholesterol, have demonstrated certain selective toxicity to…
View article: Receptor-ligand interactions for optimized endocytosis in targeted therapies
Receptor-ligand interactions for optimized endocytosis in targeted therapies Open
Receptor-mediated endocytosis plays a crucial role in the success of numerous therapies and remains central to advancing drug development. This process begins with ligand binding to specific receptors, triggering the internalization and in…
View article: Validation of DoriVac (DNA origami vaccine) efficacy in a metastatic melanoma model
Validation of DoriVac (DNA origami vaccine) efficacy in a metastatic melanoma model Open
Metastatic cancer, particularly metastatic melanoma, poses a significant therapeutic challenge due to its resistance to standard treatments and low five-year survival rate of 20–27%. Current therapies show limited success, highlighting the…
View article: Cargo quantification of functionalized DNA origami for therapeutic application
Cargo quantification of functionalized DNA origami for therapeutic application Open
In recent years, notable advances in nanotechnology-based drug delivery have emerged. A particularly promising platform in this field is DNA origami-based nanoparticles, which offer highly programmable surfaces, providing precise control o…
View article: Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade
Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade Open
Cancer immunotherapy represents a revolutionary strategy, leveraging the patient's immune system to inhibit tumor growth and alleviate the immunosuppressive effects of the tumor microenvironment (TME). The recent emergence of immune checkp…
View article: Applications of Cu2+-Loaded Silica Nanoparticles to Photothermal Therapy and Tumor-Specific Fluorescence Imaging
Applications of Cu2+-Loaded Silica Nanoparticles to Photothermal Therapy and Tumor-Specific Fluorescence Imaging Open
Copper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their…
View article: DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases
DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases Open
Current SARS-CoV-2 vaccines have demonstrated robust induction of neutralizing antibodies and CD4+ T cell activation, however CD8+ responses are variable, and the duration of immunity and protection against variants are limited. Here we re…
View article: Controlled spatial characteristics of ligands on nanoparticles: Determinant of cellular functions
Controlled spatial characteristics of ligands on nanoparticles: Determinant of cellular functions Open
Interactions of various ligands and receptors have been extensively investigated because they regulate a series of signal transduction leading to various functional cellular outcomes. The receptors on cell membrane recognize their specific…
View article: Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination
Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination Open
Multivalent presentation of ligands often enhances receptor activation and downstream signaling. DNA origami offers precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanoparticles. Here we introduce a “squa…
View article: Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation
Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation Open
Nicotinamide adenine dinucleotide (NAD + ) is an important cofactor in many redox and non-redox NAD + -consuming enzyme reactions. Intracellular NAD + level steadily declines with age, but its role in the innate immune potential of myeloid…
View article: RNAi-Based Approaches for Pancreatic Cancer Therapy
RNAi-Based Approaches for Pancreatic Cancer Therapy Open
Pancreatic cancer is one of the most lethal forms of cancer, predicted to be the second leading cause of cancer-associated death by 2025. Despite intensive research for effective treatment strategies and novel anticancer drugs over the pas…
View article: Detection of Lysyl Oxidase Activity in Tumor Extracellular Matrix Using Peptide-Functionalized Gold Nanoprobes
Detection of Lysyl Oxidase Activity in Tumor Extracellular Matrix Using Peptide-Functionalized Gold Nanoprobes Open
High LOX levels in the tumor microenvironment causes the cross-linking of extracellular matrix components and increases the stiffness of tumor tissue. Thus, LOX plays an important role in tumorigenesis and in lowering the tumor response to…
View article: Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment Open
The use of nanomedicine for cancer treatment takes advantage of its preferential accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The development of cancer nanomedicine has promised highly effective tre…
View article: Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy
Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy Open
Cancer immunotherapy is an attractive treatment option under clinical settings. However, the major challenges of immunotherapy include limited patient response, limited tumor specificity, immune-related adverse events, and immunosuppressiv…
View article: Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape
Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape Open
Designer nanoparticles with controlled shapes and sizes are increasingly popular vehicles for therapeutic delivery due to their enhanced cell-delivery performance. However, our ability to fashion nanoparticles has offered only limited cont…
View article: Research Article Microarray analysis of NSAIDs-treated cardiomyocytes to search for genes involved in COX-2 inhibitor cardiotoxicity
Research Article Microarray analysis of NSAIDs-treated cardiomyocytes to search for genes involved in COX-2 inhibitor cardiotoxicity Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely-used medications for the treatment of many inflammatory diseases. .They inhibit cyclooxygenase (COX) enzymes as a primary mechanism of action.However, many of these drugs were withd…
View article: Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli Open
Direct thrombus imaging visualizes the root cause of thromboembolic infarction. Being able to image thrombus directly allows far better investigation of stroke than relying on indirect measurements, and will be a potent and robust vascular…
View article: Engineered Proteinticles for Targeted Delivery of siRNA to Cancer Cells
Engineered Proteinticles for Targeted Delivery of siRNA to Cancer Cells Open
Considering the problems of small interfering RNA (siRNA) delivery using traditional viral and nonviral vehicles, a new siRNA delivery system to enhance efficiency and safety needs to be developed. Here human ferritin‐based proteinticles a…
View article: Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles
Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles Open
Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic index. We aimed to d…