Yingjun Jiang
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View article: Correction: Adaptive dynamic ϵ-simulated annealing algorithm for tumor immunotherapy
Correction: Adaptive dynamic ϵ-simulated annealing algorithm for tumor immunotherapy Open
[This corrects the article DOI: 10.3389/fimmu.2025.1603551.].
View article: The ionic and protonation states of flavin control the activation and recovery of Drosophila cryptochrome
The ionic and protonation states of flavin control the activation and recovery of Drosophila cryptochrome Open
Drosophila cryptochrome (dCry) is a flavin-containing photoreceptor. The release of C-terminal tail (CTT) upon illumination is a crucial step for the light sensing of dCry. Here, we demonstrated that both anionic semiquinone (asq) and anio…
View article: Correlation between virological response and portal vein thrombosis in patients with chronic hepatitis B
Correlation between virological response and portal vein thrombosis in patients with chronic hepatitis B Open
View article: Adaptive dynamic ϵ-simulated annealing algorithm for tumor immunotherapy
Adaptive dynamic ϵ-simulated annealing algorithm for tumor immunotherapy Open
Introduction Personalized cancer treatment requires precise scheduling of multiple therapeutic agents under biological constraints. Optimizing such regimens is especially challenging due to the nonlinear dynamics of tumor-immune interactio…
View article: Rutting Behavior of Dual-Layer Asphalt Pavements Subjected to Variable Temperature
Rutting Behavior of Dual-Layer Asphalt Pavements Subjected to Variable Temperature Open
Traditional laboratory rutting tests are performed at a constant temperature by neglecting pavement temperature variation. The mechanical properties of asphalt are susceptible to temperature variation. This sensitivity to temperature varia…
View article: Temperature field study of LSAM-50 flexible base asphalt pavement
Temperature field study of LSAM-50 flexible base asphalt pavement Open
Recent research has shown that increasing the aggregate particle size and forming a compact, skeleton-dense structure can effectively control reflective cracking and improve rutting resistance of the road, thereby extending the service lif…
View article: The ionic and protonation states of flavin control the activation and recovery of Drosophila cryptochrome
The ionic and protonation states of flavin control the activation and recovery of Drosophila cryptochrome Open
Drosophila cryptochrome (dCry) is a flavin-containing photoreceptor that entrains the circadian clock with light. The C-terminal tail (CTT) release upon illumination is a crucial step for light signal transduction of dCry. Here, we demonst…
View article: Fatigue Cracking Characteristics of Ultra-Large Particle Size Asphalt Mixture Under Temperature and Loading Using Digital Image Correlation Techniques
Fatigue Cracking Characteristics of Ultra-Large Particle Size Asphalt Mixture Under Temperature and Loading Using Digital Image Correlation Techniques Open
This study quantitatively investigates the fatigue cracking behavior of ultra-large particle size asphalt mixture (LSAM-50) under coupled temperature and stress effects. Fatigue tests were conducted across temperatures ranging from −15 °C …
View article: Deformation properties of remolded loess compacted via vertical vibration compaction method
Deformation properties of remolded loess compacted via vertical vibration compaction method Open
To investigate the deformation properties of remolded loess subgrade under long-term cyclic dynamic loading, remolded loess specimens compacted via vertical vibration compaction method were produced and some factors influencing elastic str…
View article: A Versatile Injectable Carboxymethyl Chitosan/Polyglutamic Acid/Dopamine Hydrogel with Photothermal Antibacterial Activity for Hemostasis and Wound Repair
A Versatile Injectable Carboxymethyl Chitosan/Polyglutamic Acid/Dopamine Hydrogel with Photothermal Antibacterial Activity for Hemostasis and Wound Repair Open
View article: P731: Clinical significance of mRNA nonstop decay in rare disease diagnosis
P731: Clinical significance of mRNA nonstop decay in rare disease diagnosis Open
View article: Investigation of indoor and field tests on asphalt pavement with inverted asphalt layers based on the vertical vibration compaction method
Investigation of indoor and field tests on asphalt pavement with inverted asphalt layers based on the vertical vibration compaction method Open
An inverted asphalt pavement is created by reversing the sequence of the lower and middle layers in a conventional asphalt pavement. The lower layer is composed of material with larger particle size and lower asphalt content, which improve…
View article: Development and Road Performance Verification of Aggregate Gradation for Large Stone Asphalt Mixture
Development and Road Performance Verification of Aggregate Gradation for Large Stone Asphalt Mixture Open
The pavement base and subbase are the main load-bearing structures of asphalt pavement, and their materials need to have sufficient bearing capacity. Therefore, in the development of LSAM-50 mixtures with higher bearing capacity, after sig…
View article: Design of Volume Parameters of Large-Particle-Size Asphalt Mixture Based on the Vertical Vibration Compaction Method
Design of Volume Parameters of Large-Particle-Size Asphalt Mixture Based on the Vertical Vibration Compaction Method Open
Volume parameters such as the volume of voids (VV), voids filled with asphalt (VFA), and voids in mineral aggregates (VMA) all have significant impact on asphalt mixtures. In this study, the vertical vibration compaction method (VVCM) was …
View article: Shear Bond Strength of Resin to Additively Manufactured Zirconia with Different Surface Treatments
Shear Bond Strength of Resin to Additively Manufactured Zirconia with Different Surface Treatments Open
View article: P730: Development of comprehensive gene-/disease-specific analysis and knowledgebase to enhance the efficiency and accuracy of sequence variant interpretation and clinical reporting
P730: Development of comprehensive gene-/disease-specific analysis and knowledgebase to enhance the efficiency and accuracy of sequence variant interpretation and clinical reporting Open
With advances in high-throughput genomic sequencing technologies, clinical molecular laboratories are evaluating a rapidly increasing number of novel sequence variants in genes associated with genetic disorders. The evidence and knowledge …
View article: Supplementary Data Figure S7 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S7 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S7 shows live cell imaging video clip accompanying Figure 6.
View article: Supplementary Data Figure S2 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S2 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S2 shows comet assays of UV41 (Xpf mutant) and AA8 (WT) cells in response to CNDAC treatment.
View article: Supplementary Data Figure S2 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S2 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S2 shows comet assays of UV41 (Xpf mutant) and AA8 (WT) cells in response to CNDAC treatment.
View article: Supplemental data legends from Mechanism-Based Drug Combinations with the DNA Strand–Breaking Nucleoside Analog CNDAC
Supplemental data legends from Mechanism-Based Drug Combinations with the DNA Strand–Breaking Nucleoside Analog CNDAC Open
legends for 6 supplemental figures and 1 supplemental table
View article: Supplementary Data Table S1 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Table S1 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Table S1 shows increase in multinucleate cells after washout of CNDAC - a 15-hr schedule.
View article: Supplementary Data Figure S6 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S6 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S6 shows time-lapse video microscopy of lung cancer H460 cells after washout of CNDAC.
View article: Supplementary Data Figure S3 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S3 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S3 shows proliferation rate of mouse and human cell lines proficient and deficient in DNA polymerase Pol theta in culture.
View article: Supplementary Data Figure S1 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S1 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S1 shows cell cycle progression of CHO cell lines proficient and deficient in XPF after CNDAC treatment.
View article: Supplementary Data Figure S5 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S5 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S5 shows timelines of CNDAC treatment and washout, and the criteria for cell tracking in live cell imaging of AA8 (A) and H460 (B) cell lines.
View article: Supplementary Data Figure S5 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S5 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S5 shows timelines of CNDAC treatment and washout, and the criteria for cell tracking in live cell imaging of AA8 (A) and H460 (B) cell lines.
View article: Data from Mechanism-Based Drug Combinations with the DNA Strand–Breaking Nucleoside Analog CNDAC
Data from Mechanism-Based Drug Combinations with the DNA Strand–Breaking Nucleoside Analog CNDAC Open
CNDAC (2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosyl-cytosine, DFP10917) and its orally bioavailable prodrug, sapacitabine, are undergoing clinical trials for hematologic malignancies and solid tumors. The unique action me…
View article: Supplementary Data Figure S8 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S8 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S8 shows multinucleation or nuclear fragmentation revealed in AA8 cells stably expressing H2B-GFP after CNDAC washout.
View article: Supplementary Data Figure S3 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S3 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S3 shows proliferation rate of mouse and human cell lines proficient and deficient in DNA polymerase Pol theta in culture.
View article: Supplementary Data Figure S4 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death
Supplementary Data Figure S4 from CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death Open
Supplemental Figure S4 shows ncuclear morphological categories of Giemsa-stained cells after cytospin.