Juan A. Pineda
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View article: Evaluación rápida del estado de condición ecológica de arrecifes coralinos mesofóticos del sistema arrecifal veracruzano
Evaluación rápida del estado de condición ecológica de arrecifes coralinos mesofóticos del sistema arrecifal veracruzano Open
Los ecosistemas coralinos mesofóticos son comunidades que se distribuyen típicamente a profundidades entre 30 a 150 m, dependiendo de la transparencia de la columna de agua. El estudio de estos ecosistemas ha cobrado interés recientemente,…
View article: Cassini: streamlined and scalable method for in situ profiling of RNA and protein
Cassini: streamlined and scalable method for in situ profiling of RNA and protein Open
In the expanding field of spatial genomics, numerous methods have emerged to decode biomolecules in intact tissue sections. Advanced techniques based on combinatorial decoding can resolve thousands of features in a reasonable time but are …
View article: Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis Open
Objetive: This study analyses liver stiffness (LS) dynamics in people living with HIV (PLWH) and advanced liver fibrosis who achieved SVR and assess factors associated with LS normalization or progression, after long-term follow-up. Design…
View article: Progression towards microelimination of hepatitis B virus infection among people living with HIV in Spain
Progression towards microelimination of hepatitis B virus infection among people living with HIV in Spain Open
The incidence of HBV infection among PLWH in Spain is close to the WHO target. The prevalence of active HBV infection has decreased substantially during the last 12 years. These data suggest that micro-elimination of HBV/HIV infection is o…
View article: Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response
Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response Open
Project PI19/01443, ERDF/ESF "Investing in your future", GLD21_00096, GEHEP-011 project, B-0061-2021, JR24/00044, A1-0060-2021, CM23/00255, CM22/00176.
View article: FibroScan-AST Score vs Liver Stiffness for the Prediction of Liver Events After HCV Cure
FibroScan-AST Score vs Liver Stiffness for the Prediction of Liver Events After HCV Cure Open
Background Liver stiffness (LS) predicts liver complication occurrence in patients with hepatitis C virus (HCV) infection after sustained virological response (SVR). The FibroScan-AST (FAST) score, which includes aspartate aminotransferase…
View article: Letter: Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With <scp>HIV</scp>—Authors' Reply
Letter: Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With <span>HIV</span>—Authors' Reply Open
We thank Ng et al. [1] for their interest and comments on our research article [2]. They rightly point out the role of liver stiffness measurement (LSM) in the predictive value of the FAST score. Indeed, we proposed the use of LSM instead …
View article: Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response Open
Background Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters a…
View article: Risk of Adverse Reactions to Oat-Based Topical Therapies in Atopic Dermatitis Patients with Avenin Allergy
Risk of Adverse Reactions to Oat-Based Topical Therapies in Atopic Dermatitis Patients with Avenin Allergy Open
View article: Entrevista a un actor protagónico del municipio de Chiquinquirá, Boyacá
Entrevista a un actor protagónico del municipio de Chiquinquirá, Boyacá Open
Mediante el desarrollo del programa de Maestría en Gobierno, Políticas Públicas y Desarrollo Territorial se logró determinar para el curso Medio Ambiente, Ruralidad y Territorio la realización de esta entrevista a un actor protagónico que …
View article: Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein
Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein Open
In the expanding field of spatial genomics, numerous methods have emerged to decode biomolecules in intact tissue. Advanced techniques based on combinatorial decoding can resolve thousands of features in a reasonable time but are often con…
View article: Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With <scp>HIV</scp>
Impact of Nonalcoholic Fatty Liver Disease on the Survival of People Living With <span>HIV</span> Open
Background Nonalcoholic fatty liver disease (NAFLD) is an increasing concern for people living with HIV (PLWH). However, information on the impact of NAFLD on the prognosis of PLWH is very scarce. Aims To investigate the influence of NAFLD…
View article: Evaluación del Impacto de las herramientas interactivas en la enseñanza presencial
Evaluación del Impacto de las herramientas interactivas en la enseñanza presencial Open
PROBLEMA: Los docentes enfrentan dificultades al integrar las TIC en la educación debido a su limitada formación, lo que afecta el proceso de enseñanza-aprendizaje. La falta de infraestructura y un propósito educativo claro empeoran esta s…
View article: Long or complicated mpox in patients with uncontrolled HIV infection
Long or complicated mpox in patients with uncontrolled HIV infection Open
To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of …
View article: The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study)
The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study) Open
Our results suggest that those KIR-HLA genotype combinations are not relevant factors involved in the lack of infection and seroconversion after exposition to HCV. More studies will be needed to completely understand this phenotype.
View article: Hepatic Steatosis and Weight Gain During the Coronavirus Disease 2019 Pandemic Among People With Human Immunodeficiency Virus: Impact of Therapy With Tenofovir Alafenamide
Hepatic Steatosis and Weight Gain During the Coronavirus Disease 2019 Pandemic Among People With Human Immunodeficiency Virus: Impact of Therapy With Tenofovir Alafenamide Open
Background Lockdown due to the coronavirus disease 2019 (COVID-19) pandemic led to increases in weight in part of the population. Weight gain leads to hepatic steatosis (HS). Antiretroviral treatment could also influence HS in people with …
View article: Prognostic value of non‐invasive scores based on liver stiffness measurement, spleen diameter and platelets in <scp>HIV</scp>‐infected patients
Prognostic value of non‐invasive scores based on liver stiffness measurement, spleen diameter and platelets in <span>HIV</span>‐infected patients Open
Background and Aims People living with HIV (PLWH) are at high risk for advanced chronic liver disease and related adverse outcomes. We aimed to validate the prognostic value of non‐invasive scores based on liver stiffness measurement (LSM)…
View article: Temporal changes in the genotypes of Paslahepevirus balayani in southern Spain and their possible link with changes in pig trade imports
Temporal changes in the genotypes of Paslahepevirus balayani in southern Spain and their possible link with changes in pig trade imports Open
HEV molecular diversity is changing in Spain, could be linked to changes in fattening pig import origin.
View article: Optimization of the molecular diagnosis of the acute <i>hepatitis E virus</i> infection
Optimization of the molecular diagnosis of the acute <i>hepatitis E virus</i> infection Open
To evaluate the diagnostic value of the combination of two broad‐range PCR assays targeting two different and conserved regions of the viral genome for the diagnosis of acute Hepatitis E virus (HEV) infection. Patients with acute hepatitis…
View article: Reduced neutralizing antibody response to SARS‐CoV‐2 vaccine booster dose in people living with HIV with severe immunosuppression
Reduced neutralizing antibody response to SARS‐CoV‐2 vaccine booster dose in people living with HIV with severe immunosuppression Open
The aim of this study was to assess the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccines among people living with HIV (PLWH) with severe immunosuppression, after a booster dose. The design was a case–…
View article: Severe acute hepatitis in a person with HIV and simultaneous infection with hepatitis C virus and SARS-CoV-2
Severe acute hepatitis in a person with HIV and simultaneous infection with hepatitis C virus and SARS-CoV-2 Open
View article: Controlled attenuation parameter-insulin resistance (CIR) score to predict non-alcoholic steatohepatitis
Controlled attenuation parameter-insulin resistance (CIR) score to predict non-alcoholic steatohepatitis Open
View article: Severe acute hepatitis in a person with HIV and simultaneous infection with hepatitis C virus and SARS-CoV-2
Severe acute hepatitis in a person with HIV and simultaneous infection with hepatitis C virus and SARS-CoV-2 Open
View article: An intragenic duplication within<i>SIRPβ1</i>shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response
An intragenic duplication within<i>SIRPβ1</i>shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response Open
Microglia play an important role in the maintenance of brain homeostasis, and microglial dysfunction plays a causative role in Alzheimer disease pathogenesis. Here we focus on the signal regulatory protein SIRPβ1, a surface receptor expres…
View article: Programa de certificación de Centros de Adicciones para la eliminación del virus de la hepatitis C en España. Proyecto HepCelentes
Programa de certificación de Centros de Adicciones para la eliminación del virus de la hepatitis C en España. Proyecto HepCelentes Open
Las estrategias de microeliminación del virus de la hepatitis C (VHC) en poblaciones vulnerables, como los usuarios de los centros de adicciones (CA), son fundamentales para lograr la eliminación de la hepatitis C. El objetivo del proyecto…
View article: No association of a risk variant for severe COVID-19 with HIV protection in three cohorts of highly exposed individuals
No association of a risk variant for severe COVID-19 with HIV protection in three cohorts of highly exposed individuals Open
An extended haplotype on chromosome 3 is the major genetic risk factor for severe COVID-19. The risk haplotype, which was inherited from Neanderthals, decreases the expression of several cytokine receptors, including CCR5. Recently, a stud…
View article: High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use Open
View article: Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV
Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV Open
View article: Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control Open
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenot…
View article: Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV
Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV Open
Background The initiation of antiretroviral treatment based on a 2-drug regimen (2DR) with dolutegravir plus lamivudine has demonstrated non-inferior efficacy than dolutegravir-based three-drug regimens (3DR). We aimed to assess whether th…