Juan C. Maass
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View article: Hyperacusis correlates with active and chronic-recurrent Vogt-Koyanagi-Harada disease
Hyperacusis correlates with active and chronic-recurrent Vogt-Koyanagi-Harada disease Open
Importance Vogt-Koyanagi-Harada disease (VKH) is a severe ocular disorder with multi-organ affection including the ear. Few studies have evaluated otolaryngologic manifestations. Current classification criteria of uveitis only includes tin…
View article: A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise
A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise Open
Introduction The functional evaluation of auditory-nerve activity in spontaneous conditions has remained elusive in humans. In animals, the frequency analysis of the round-window electrical noise recorded by means of electrocochleography y…
View article: A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise
A frequency peak at 3.1 kHz obtained from the spectral analysis of the cochlear implant electrocochleography noise Open
Introduction The functional evaluation of auditory-nerve activity in spontaneous conditions has remained elusive in humans. In animals, the frequency analysis of the round-window electrical noise recorded by means of electrocochleography y…
View article: Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice
Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice Open
Age-related hearing loss is linked to cognitive impairment, but the mechanisms that relate to these conditions remain unclear. Evidence shows that the activation of medial olivocochlear (MOC) neurons delays cochlear aging and hearing loss.…
View article: Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity
Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity Open
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxy…
View article: Color Dependence Analysis in a CNN-Based Computer-Aided Diagnosis System for Middle and External Ear Diseases
Color Dependence Analysis in a CNN-Based Computer-Aided Diagnosis System for Middle and External Ear Diseases Open
Artificial intelligence-assisted otologic diagnosis has been of growing interest in the scientific community, where middle and external ear disorders are the most frequent diseases in daily ENT practice. There are some efforts focused on r…
View article: Computer-Aided Ear Diagnosis System Based on CNN-LSTM Hybrid Learning Framework for Video Otoscopy Examination
Computer-Aided Ear Diagnosis System Based on CNN-LSTM Hybrid Learning Framework for Video Otoscopy Examination Open
Ear disorders are among the most common diseases treated in primary care, with a high
\npercentage of non-relevant referrals. The conventional diagnostic procedure is done by a visual examination
\nof the ear canal and tympanic membrane. C…
View article: Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis
Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis Open
These results evidence that reduced suprathreshold auditory nerve responses in presbycusis are associated with slower processing speed and brain structural changes in temporal and parietal regions.
View article: Preventing presbycusis in mice with enhanced medial olivocochlear feedback
Preventing presbycusis in mice with enhanced medial olivocochlear feedback Open
Significance Age-related hearing loss is the most common cause of hearing loss. Here, we show that medial olivocochlear feedback mediates resistance to age-related hearing loss—presbycusis—and that this occurs via the α9α10 cholinergic nic…
View article: Computer-aided diagnosis of external and middle ear conditions: A machine learning approach
Computer-aided diagnosis of external and middle ear conditions: A machine learning approach Open
In medicine, a misdiagnosis or the absence of specialists can affect the patient's health, leading to unnecessary tests and increasing the costs of healthcare. In particular, the lack of specialists in otolaryngology in third world countri…
View article: Reduced Suprathreshold Auditory Nerve Responses are Associated with Thinner Temporal Cortex and Slower Processing Speed in Presbycusis
Reduced Suprathreshold Auditory Nerve Responses are Associated with Thinner Temporal Cortex and Slower Processing Speed in Presbycusis Open
Epidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a suprathreshold audi…
View article: SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex
SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex Open
The development of the cerebral cortex requires the coordination of multiple processes ranging from the proliferation of progenitors to the migration and establishment of connectivity of the newborn neurons. Epigenetic regulation carried o…
View article: Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing
Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing Open
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and funct…