Explanipedia

Targeted cellular depletion in an immune-liver-on-a-chip platform elucidates cell-type-specific heterogeneity in drug-induced hepatotoxicity Open

Shuai Yuan, Shangwen Yang, Juan Chen, Chengjun Wu, Jiu Deng · 2025

Drug-induced hepatotoxicity remains a critical challenge in pharmacological safety evaluation; however, the lack of analytical tools to distinguish cell-type-specific hepatotoxic responses hinders mechanistic understanding of toxicity path…

Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility Open

Shiyong Zhang, Yuting Zhou, Yue Ren, Jian Shang, Ao Jiang , et al. · 2025

Four-limb CFST latticed columns seismic performance: experimental and ANN predictions Open

Juan Chen, Junjie He, Zhi Huang, Yuner Huang, Y. Frank Chen · 2025

Emerging Serum Biomarkers for Chronic Hepatitis B: Focus on Serum HBV RNA and HBcrAg Open

Ya‐Chung Tian, Haibo Yu, Juan Chen · 2025

Chronic hepatitis B virus (HBV) infection remains a major cause of liver diseases, including cirrhosis and hepatocellular carcinoma. Reliable biomarkers for assessing viral replication, liver damage, and predicting clinical outcomes are es…

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma Open

Minli Yang, Sheng‐Tao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang , et al. · 2025

The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to…

Tenofovir alafenamide is superior to tenofovir disoproxil fumarate and entecavir in cost-effectiveness of treatment of chronic hepatitis B in china with new volume-based procurement policy Open

Yi Lin, Xueyan Lin, Ruiming Xia, Juan Chen, Zhihui Lin , et al. · 2025

Background Evidence supports the long-term efficacy of Nucleos(t)ide Analogs (NAs) therapy in improving chronic hepatitis B (CHB) prognosis. However, determining the most cost-effective first-line NAs remains unclear. China’s implementatio…

Exploring the Importance of ZBP1 in Sepsis: A Mini Review on It’s Mechanisms and Progress Open

Jie Liu, Jian Feng, Jian Hu, Juan Chen, Fuxiang Li , et al. · 2025

Sepsis is defined as a severe systemic inflammation, often triggered by an infection, resulting in organ dysfunction and mortality. In recent years, ZBP1 (Z-DNA binding protein 1) has garnered significant attention as a critical immune reg…

HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages Open

Jiaxin Zhou, Liang‐Wen Ding, Juan Chen, Chen Chen, Ping Jiang , et al. · 2025

HMGB1 can enhance TRAF6-mediated NF-κB activation, thereby driving M1 macrophage polarization and exacerbating prostate inflammation in EAP mice. Inhibiting HMGB1 expression with glycyrrhizin can suppress M1 polarization of macrophages to …

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion Open

Yanying Zhao, Zhengwei Ge, Tingting Guo, Hengwei Liu, Yufan Zhou , et al. · 2025

The complement C3/C3aR signaling pathway is critically involved in RVO-induced retinal damage and targeting this pathway may be a promising approach for RVO treatment.

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry Open

Jia He, Haibo Yu, Kunling Song, Ailong Huang, Yongjun Dang , et al. · 2025

Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals Open

Xinxin Ma, Fang Liu, Lei Qiu, Juan Chen, Wei Du , et al. · 2025

Objectives Cerebral small vascular disease ( CSVD ) is not rare in neurologically asymptomatic individuals. Glucose control and insulin resistance ( IR ) may be its risk factors. We aimed to explore the relationship between CSVD markers, g…

TsRNA-49–73-Glu-CTC: A promising serum biomarker in non-small cell lung cancer Open

Chenyu Li, Shenjie Zhong, Juan Chen, Xingyu Mu · 2025

Objective Lung cancer has the highest incidence and mortality rates globally, with the majority of cases classified as non-small cell lung cancer (NSCLC). Due to the absence of specific tumor biomarkers, most lung cancer cases are diagnose…

Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome Open

Sheng‐Tao Cheng, Weixian Chen, Haijun Deng, Xin He, Hui Zhang , et al. · 2025

Background/Aims: Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interac…

Performance-Based Multi-Objective Optimization of Four-Limb CFST Lattice Columns Open

Junjie He, Zhi Huang, Juan Chen, Wangbao Zhou, Tao Huang , et al. · 2025

In this paper, the low-cycle reciprocating load test was carried out on four-limb concrete-filled steel tubular (CFST) lattice columns with different slenderness ratios and axial compression ratios, and the seismic performance was studied.…

A novel duplication frame-shift mutation in the BAG3 gene in a patient with dilated cardiomyopathy Open

Wei Zhang, Kaihang Xu, Shiguang Liu, Juan Chen, Hua Jiang · 2024

Background/Objectives: Dilated cardiomyopathy (DCM) is characterized by heart failure and a dilated heart and is different from ischemic and non-ischemic heart disease. To date, more than 50 genes have been found associated with DCM. Bcl–2…

Blood Inflammatory Markers and Cytokines in COVID‐19 Patients With Bacterial Coinfections Open

Qingqing Bi, Jie Zhu, Jinju Zheng, Qingyun Xu, Juan Chen , et al. · 2024

Background Bacterial coinfection in patients with SARS‐CoV‐2 infection is an important risk factor for death. This study investigated whether there were differences in levels of serum inflammatory markers in COVID‐19 patients with bacteria…

Chinese Expert Consensus on the Whole-Course Management of Hepatocellular Carcinoma (2023 Edition) Open

Yang Yu, Juxian Sun, Jianqiang Cai, Minshan Chen, Chaoliu Dai , et al. · 2024

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. Most HCC patients have the complications of chronic liver disease and need overall consideration and whole-course management, including diagnos…

Similarity-based metric analysis approach for predicting osteogenic differentiation correlation coefficients and discovering the novel osteogenic-related gene FOXA1 in BMSCs Open

Lingtong Sun, Juan Chen, Li Jun Li, Ling-Di Li · 2024

Background As a powerful tool, bioinformatics analysis is playing an increasingly important role in many fields. Osteogenic differentiation is a complex biological process involving the fine regulation of numerous genes and signaling pathw…

Correction for: PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis Open

Juan Chen, Xiaoliang Hua, Heying Chen, Xiangmin Qiu, Haibing Xiao , et al. · 2024

Signaling molecules in the microenvironment of hepatocellular carcinoma Open

Wan‐Jin Chen, Ming Tan, Hui Zhang, Tingting Gao, Ji‐Hua Ren , et al. · 2024

Hepatocellular carcinoma (HCC) is a major fatal cancer that is known for its high recurrence and metastasis. An increasing number of studies have shown that the tumor microenvironment is closely related to the metastasis and invasion of HC…

Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression Open

Hui Zhang, Xiameng Su, Leirong Gu, Ming Tan, Yu‐Ting Liu , et al. · 2024

The HBV core protein (HBc) is an important viral protein of HBV that plays an indispensable role in the lifecycle of HBV, including capsid assembly and transport, reverse transcription and virus release. In recent years, evidence has shown…

Development and evaluation of vaccination strategies for addressing the continuous evolution SARS-CoV-2 based on recombinant trimeric protein technology: Potential for cross-neutralizing activity and broad coronavirus response Open

Peng Du, Ning Li, Shengjun Tang, Zhongcheng Zhou, Zhihai Liu , et al. · 2024

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B Open

Li Wang, Fangli Liao, Liping Yang, Linshan Jiang, Liang Duan , et al. · 2024

Killer cell lectin-like receptor G1 (KLRG1) has traditionally been regarded as an inhibitory receptor of T cell exhaustion in chronic infection and inflammation. However, its exact role in hepatitis B virus (HBV) infection remains elusive.…

Multi-cohort study on cytokine and chemokine profiles in the progression of COVID-19 Open

Chaolin Huang, Xujuan Hu, Delong Wang, Rui Gong, Qiongya Wang , et al. · 2024

Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate biomarkers. Cytokines and chemoki…

Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection Open

Bingbing Ma, Jie Zhou, Weijuan Zhou, Zhanzhong Ma, Juan Chen , et al. · 2024

HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome Open

Yi-Ping Qin, Ji‐Hua Ren, Haibo Yu, Xin He, Sheng‐Tao Cheng , et al. · 2024

Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV. Long non‐coding RNAs (…

Blood inflammatory markers and cytokines in patients with COVID-19 and bacterial coinfections Open

Qingqing Bi, Jie Zhu, Jinju Zheng, Qingyun Xu, Juan Chen , et al. · 2024

Background: Bacterial coinfection in patients with SARS-CoV-2 infection is an important risk factor for death. This study investigated and analyzed whether there were differences in levels of serum inflammatory markers in patients with SAR…

Advances in fecal microbiota transplantation for the treatment of diabetes mellitus Open

Juan Zhang, Honggang Wang, Ying Liu, Min Shi, Minna Zhang , et al. · 2024

Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm various organ systems and lead to acute or chronic complications,…

Corrigendum: Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9 Open

Min-Li Yang, Yujiao Zhou, Haijun Deng, Hongzhong Zhou, Sheng‐Tao Cheng , et al. · 2024

[This corrects the article DOI: 10.3389/fonc.2021.779748.].

The occurrence of asthma in an extensive-stage small-cell lung cancer patient after combination therapy with atezolizumab and anlotinib: a case report Open

Wang Deng, Juan Chen, Xinyu Deng · 2024

Background Extensive-stage small-cell lung cancer (ES-SCLC) is highly malignant, with early metastasis and high recurrence. Since therapeutic options are limited, ES-SCLC has a characteristically short survival period and extremely poor pr…

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