Juan Carlo Santos e Silva
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View article: In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis
In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis Open
View article: CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS
CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS Open
SUMMARY Tuberculosis induces diverse lesions, such as necrotic pneumonia, contributing to disease progression and transmission. Despite advances in understanding the role of ATP-gated P2RX7 ion channels in developing severe forms of tuberc…
View article: Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms
Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms Open
View article: Distinct CD4 T-Cell Subsets Predict Lung Cancer Immunotherapy Failure and Identify Patients for Dual Blockade
Distinct CD4 T-Cell Subsets Predict Lung Cancer Immunotherapy Failure and Identify Patients for Dual Blockade Open
View article: Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility
Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility Open
Thyroid autoimmune diseases, such as Hashimoto thyroiditis and Graves disease, are significantly more prevalent in women than in men, suggesting underlying biological differences in immune system function and regulation between sexes. Plas…
View article: Morphological profiling of T cells predicts clinical response to VLA-4-targeting natalizumab therapy in patients with multiple sclerosis
Morphological profiling of T cells predicts clinical response to VLA-4-targeting natalizumab therapy in patients with multiple sclerosis Open
View article: Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms
Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms Open
The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates the potential association between specific autoantibodies (A…
View article: Ten quick tips for harnessing the power of ChatGPT in computational biology
Ten quick tips for harnessing the power of ChatGPT in computational biology Open
The rise of advanced chatbots, such as ChatGPT, has stirred excitement and curiosity in the scientific community.Powered by large language models (LLMs) based on generative pretrained transformers (GPTs)-specifically GPT-3.5 and GPT-4-Chat…
View article: Tucuxi-BLAST: Enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach
Tucuxi-BLAST: Enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach Open
Background Public health research frequently requires the integration of information from different data sources. However, errors in the records and the high computational costs involved make linking large administrative databases using re…
View article: Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology Open
Background The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19…
View article: HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria Open
Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum , scarce data exist regarding t…
View article: Gasdermin-D activation by SARS-CoV-2 trigger NET and mediate COVID-19 immunopathology
Gasdermin-D activation by SARS-CoV-2 trigger NET and mediate COVID-19 immunopathology Open
The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19 remain unc…
View article: Enabling Fast and Accurate Record Linkage of Large-Scale Health-Related Administrative Databases Through a DNA-Encoded Approach
Enabling Fast and Accurate Record Linkage of Large-Scale Health-Related Administrative Databases Through a DNA-Encoded Approach Open
View article: Gene signatures of autopsy lungs from obese patients with COVID-19
Gene signatures of autopsy lungs from obese patients with COVID-19 Open
View article: P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis
P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis Open
The risk of developing severe forms of tuberculosis has increased by the acquired immunodeficiency syndrome (AIDS) epidemic, lack of effective drugs to eliminate latent infection and the emergence of drug-resistant mycobacterial strains. E…
View article: In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19
In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19 Open
View article: In-depth Analysis of Laboratory Parameters Reveals the Interplay Between Sex, Age and Systemic Inflammation in Individuals with COVID-19
In-depth Analysis of Laboratory Parameters Reveals the Interplay Between Sex, Age and Systemic Inflammation in Individuals with COVID-19 Open
Introduction The progression and severity of the coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), varies significantly in the population. While the hallm…
View article: Pervasive Inter-Individual Variation in Allele-Specific Expression in Monozygotic Twins
Pervasive Inter-Individual Variation in Allele-Specific Expression in Monozygotic Twins Open
Despite being developed from one zygote, heterokaryotypic monozygotic (MZ) co-twins exhibit discordant karyotypes. Epigenomic studies in biological samples from heterokaryotypic MZ co-twins are of the most significant value for assessing t…