Juan Carlos Fernández-López
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View article: High-density LD-based structural variations analysis in ten Native and Mestizo Mexican populations
High-density LD-based structural variations analysis in ten Native and Mestizo Mexican populations Open
The main objective of this study was to perform a genome-wide characterization of Structural Variations (SV) based on the deviation of the expected short-range Linkage Disequilibrium (LD) between Single Nucleotide Polymorphisms (SNPs) in 1…
View article: EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1
EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1 Open
Gene methylation changes are linked to lung remodeling, immune response, mucus production, and xenobiotic metabolism. Hypermethylation of the cg08450425 site (EDN1) is significant in women with COPD and associated with low endotheli…
View article: Editorial: Advancements and prospects of genome-wide association studies
Editorial: Advancements and prospects of genome-wide association studies Open
View article: Genome-wide association study reveals polymorphisms associated with total number born in pigs in mexican Landrace-Yorkshire sows
Genome-wide association study reveals polymorphisms associated with total number born in pigs in mexican Landrace-Yorkshire sows Open
Genome-wide association studies (GWAS) are based on the field of animal genetics, and have the power to detect mutations, facilitating the identification of diverse productive traits. This study aimed to elucidate how single-nucleotide pol…
View article: An EWAS in COPD Secondary to Biomass-Burning Smoke Exposure Identifies Low Levels of Endothelin-1 by Hypermethylation of cg08450425 in EDN1
An EWAS in COPD Secondary to Biomass-Burning Smoke Exposure Identifies Low Levels of Endothelin-1 by Hypermethylation of cg08450425 in EDN1 Open
View article: Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population
Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population Open
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs being one of the affected areas. Among these, damage to the pulmonary interstitium (I…
View article: Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population
Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population Open
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs one of the affected areas. Among these, damage to the pulmonary interstitium (Interst…
View article: Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients
Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients Open
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, the presence of anti-citrullinated protein antibodies (ACPA) is a common feature, which is cause…
View article: SNPs Sets in Codifying Genes for Xenobiotics-Processing Enzymes Are Associated with COPD Secondary to Biomass-Burning Smoke
SNPs Sets in Codifying Genes for Xenobiotics-Processing Enzymes Are Associated with COPD Secondary to Biomass-Burning Smoke Open
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; the main risk factors associated with the suffering are tobacco smoking (TS) and chronic exposure to biomass-burning smoke (BBS). Different biologi…
View article: Virtual and Augmented Reality versus Traditional Methods for Teaching Physiotherapy: A Systematic Review
Virtual and Augmented Reality versus Traditional Methods for Teaching Physiotherapy: A Systematic Review Open
The use of virtual worlds in health-related education is increasingly popular, but an overview of their use in physiotherapy education is still needed. The aim of this review was to analyse the use of virtual and augmented reality (VR/AR) …
View article: Correction: Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights
Correction: Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights Open
[This corrects the article DOI: 10.1371/journal.pone.0249773.].
View article: Comprehensive omic characterization of breast cancer in Mexican-Hispanic women
Comprehensive omic characterization of breast cancer in Mexican-Hispanic women Open
View article: Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights
Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights Open
There has been limited study of Native American whole genome diversity to date, which impairs effective implementation of personalized medicine and a detailed description of its demographic history. Here we report high coverage whole genom…
View article: Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population
Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population Open
Genetic variability influences the susceptibility to and severity of complex diseases; there is a lower risk of COPD in Hispanics than in non-Hispanic Caucasians. In this study, we included 830 Mexican-Mestizo subjects; 299 were patients w…
View article: The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population
The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population Open
The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we pe…
View article: Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia Open
Background: Acute lymphoblastic leukemia (ALL) is the main type of cancer in children. In Mexico and other Hispanic populations, the incidence of this neoplasm is one of the highest reported worldwide. Functional polymorphisms of va…
View article: Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans
Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans Open
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a sub…
View article: Population and breast cancer patients’ analysis reveals the diversity of genomic variation of the BRCA genes in the Mexican population
Population and breast cancer patients’ analysis reveals the diversity of genomic variation of the BRCA genes in the Mexican population Open
View article: A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos
A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos Open
View article: Additional file 6 of A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos
Additional file 6 of A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos Open
Additional_Parental_AIMs.txt. Genotypes of our subset of 32 AIMs from the two parental populations of Mexican mestizos. (TXT 10 kb)
View article: Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing
Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing Open
View article: A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density
A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density Open
To identify genetic variants influencing bone mineral density (BMD) in the Mexican-Mestizo population, we performed a GWAS for femoral neck (FN) and lumbar spine (LS) in Mexican-Mestizo postmenopausal women. In the discovery sample, 300,00…
View article: Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico
Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico Open
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants hav…
View article: SNPs in <i>NRXN1</i> and <i>CHRNA5</i> are Associated to Smoking and Regulation of Gabaergic and Glutamatergic Pathways
SNPs in <i>NRXN1</i> and <i>CHRNA5</i> are Associated to Smoking and Regulation of Gabaergic and Glutamatergic Pathways Open
In a Mexican Mestizo population, greater consumption of cigarettes was influenced by polymorphisms in the NRXN1 and CHRNA5 genes. We proposed new hypotheses regarding the putative roles of miRNAs that influence the GABAergic and glutamater…
View article: Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana
Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana Open
An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in…
View article: Genetic Variants in <i>IL6R</i> and <i>ADAM19</i> are Associated with COPD Severity in a Mexican Mestizo Population
Genetic Variants in <i>IL6R</i> and <i>ADAM19</i> are Associated with COPD Severity in a Mexican Mestizo Population Open
Chronic obstructive pulmonary disease (COPD) is a complex and multifactorial disease with a strong genetic component. Our objective is to identify the genetic variants associated with COPD risk and its severity in Mexican Mestizo populatio…