Juan Cristóbal Gana
YOU?
Author Swipe
View article: Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis in a Tertiary Hospital in the Philippines: A Case Series and Review of Literature
Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis in a Tertiary Hospital in the Philippines: A Case Series and Review of Literature Open
Background and objectives: Hemophagocytic Lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by uncontrolled immune activation leading to multiorgan dysfunction. It poses significant diagnostic and the…
View article: Incidencia de infecciones en pacientes pediátricos usuarios de terapia biológica
Incidencia de infecciones en pacientes pediátricos usuarios de terapia biológica Open
Las terapias biológicas han mejorado el pronóstico de las personas con enfermedades inflamatorias. En usuarios adultos se ha reportado un riesgo aumentado de presentar infecciones, sin embargo, existen pocos estudios pediátricos. Objetivo:…
View article: Circulating Bilirubin Levels, but Not Their Genetic Determinants, Are Inversely Associated with Steatotic Liver Disease in Adolescents
Circulating Bilirubin Levels, but Not Their Genetic Determinants, Are Inversely Associated with Steatotic Liver Disease in Adolescents Open
Epidemiologic studies suggest that elevated plasma unconjugated bilirubin confer protection against steatotic liver disease (SLD) in adults. However, evidence supporting this protective role in adolescents remains limited. We aimed to asse…
View article: Prevalence of fatty pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study
Prevalence of fatty pancreas and its relation with anthropometric values on the Growth and Obesity Cohort Study Open
In adolescents, NAFPD has a prevalence of 4 % and is associated with a higher BMI z-score, WC, superficial fat, and blood pressure levels. Liver steatosis exhibited a strong association with NAFPD.
View article: Genetic determinants of serum bilirubin using inferred native American gene variants in Chilean adolescents
Genetic determinants of serum bilirubin using inferred native American gene variants in Chilean adolescents Open
Gene variants in the UGT1A1 gene are strongly associated with circulating bilirubin levels in several populations, as well as other variants of modest effect across the genome. However, the effects of such variants are unknown regarding th…
View article: Pancreatitis aguda grave secundaria a hipertrigliceridemia como debut de Diabetes Mellitus Tipo 1 en edad pediátrica
Pancreatitis aguda grave secundaria a hipertrigliceridemia como debut de Diabetes Mellitus Tipo 1 en edad pediátrica Open
La pancreatitis aguda (PA) inducida por hipertrigliceridemia (HTG) secundaria a déficit de insulina en el contexto de un debut de diabetes mellitus tipo 1 (DM1) es una complicación infrecuente pero grave en niños.Objetivo: describir el dia…
View article: Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk
Relation between Body Composition Trajectories from Childhood to Adolescence and Nonalcoholic Fatty Liver Disease Risk Open
NAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and …
View article: Dietary and Nutritional Interventions in Nonalcoholic Fatty Liver Disease in Pediatrics
Dietary and Nutritional Interventions in Nonalcoholic Fatty Liver Disease in Pediatrics Open
Nonalcoholic fatty liver disease (NAFLD) is pediatrics’ most common chronic liver disease. The incidence is high in children and adolescents with obesity, which is associated with an increased risk of disease progression. Currently, there …
View article: Liver PDFF estimation using a multi-decoder water-fat separation neural network with a reduced number of echoes
Liver PDFF estimation using a multi-decoder water-fat separation neural network with a reduced number of echoes Open
Objective To accurately estimate liver PDFF from chemical shift-encoded (CSE) MRI using a deep learning (DL)-based Multi-Decoder Water-Fat separation Network (MDWF-Net), that operates over complex-valued CSE-MR images with only 3 echoes. M…
View article: New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry
New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry Open
Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost excl…
View article: Gastrostomy plus fundoplication or gastro-jejunal tube versus gastrostomy alone for gastro-esophageal reflux in children with neurological impairment
Gastrostomy plus fundoplication or gastro-jejunal tube versus gastrostomy alone for gastro-esophageal reflux in children with neurological impairment Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of the two most common enteral feeding tubes and associated antireflux procedures. We aim to compare: (1) gastrostomy …
View article: Tumour necrosis factor-alpha antagonists for treatment of paediatric Crohn’s disease
Tumour necrosis factor-alpha antagonists for treatment of paediatric Crohn’s disease Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and safety of tumour necrosis factor‐alpha antagonists for induction of remission in children with active Crohn's disease.
View article: The Association Between Breast Density and Gut Microbiota Composition at 2 Years Post-Menarche: A Cross-Sectional Study of Adolescents in Santiago, Chile
The Association Between Breast Density and Gut Microbiota Composition at 2 Years Post-Menarche: A Cross-Sectional Study of Adolescents in Santiago, Chile Open
The gut microbiome has been linked to breast cancer via immune, inflammatory, and hormonal mechanisms. We examined the relation between adolescent breast density and gut microbial composition and function in a cohort of Chilean girls. This…
View article: Non-invasive test of liver fibrosis for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis
Non-invasive test of liver fibrosis for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis Open
This protocol for a Cochrane Review is out of date. The authors have abandoned it.
View article: Magnetic resonance imaging, computer tomography scan, and oesophagography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis
Magnetic resonance imaging, computer tomography scan, and oesophagography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis Open
This protocol for a Cochrane Review is out of date. The authors have abandoned it.
View article: Transient ultrasound elastography and magnetic resonance elastography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis
Transient ultrasound elastography and magnetic resonance elastography for the diagnosis of oesophageal varices in patients with chronic liver disease or portal vein thrombosis Open
This protocol for a Cochrane Review is out of date. The authors have abandoned it.
View article: New insights from GWAS on longitudinal and cross-sectional BMI and related phenotypes in admixed children with Native American and European ancestries
New insights from GWAS on longitudinal and cross-sectional BMI and related phenotypes in admixed children with Native American and European ancestries Open
Body-mass index (BMI) is a well-known marker of adiposity across all ages. The genetic architecture of BMI has been thoroughly studied among adults. In contrast, there are a few genome-wide association studies (GWAS) on children. Further, …
View article: Teduglutide for the treatment of patients with short bowel syndrome
Teduglutide for the treatment of patients with short bowel syndrome Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the safety and efficacy of teduglutide for the treatment of patients with short bowel syndrome when compared with placebo or no interventio…
View article: Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019
Acute Liver Injury Among Pediatric Liver Transplantation Recipients With Coronavirus Disease 2019 Open
Coronavirus disease 2019 (COVID‐19) is an ongoing pandemic. The occurrence of acute liver injury (ALI) has been reported in liver transplant (LT) recipients; however, the findings on children remain controversial. This is the first extensi…
View article: Effect of music on pediatric endoscopic examinations: a randomized controlled trial
Effect of music on pediatric endoscopic examinations: a randomized controlled trial Open
Background and study aims The primary objective was to measure the effect of music as an adjunct to sedation in patient anxiety levels during pediatric endoscopic examinations. Patients and methods We performed a single-blind randomized co…
View article: Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis
Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis Open
The evidence, obtained from only one feasibility randomised clinical trial at high risk of bias, is very scanty. It is very uncertain about whether prophylactic band ligation versus sham or no (active) intervention may affect mortality, se…
View article: INDICACIONES INHABITUALES DE TRASPLANTE HEPÁTICO. RESULTADOS
INDICACIONES INHABITUALES DE TRASPLANTE HEPÁTICO. RESULTADOS Open
Introducción: El trasplante hepático (TH), es una terapia establecida en el tratamiento de diversas enfermedades del hígado agudas y crónicas terminales y del carcinoma hepatocelular (CHC). Las principales indicaciones en nuestro medio son…
View article: Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease
Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease Open
Non-alcoholic fatty liver disease (NAFLD) is currently the most common form of liver disease in both adults and children, becoming the leading cause for liver transplant in many countries. Its prevalence has increased considerably in recen…
View article: Band ligation versus sclerotherapy for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Band ligation versus sclerotherapy for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis Open
Randomised clinical trials assessing the benefits or harms of band ligation versus sclerotherapy for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis are lacking. Therefo…
View article: Adaptación a la realidad de Latinoamérica de la Guía Clínica NASPGHAN/ESPGHAN 2016 sobre Diagnóstico, Prevención y Tratamiento de Infección por Helicobacter pylori en Pediatría
Adaptación a la realidad de Latinoamérica de la Guía Clínica NASPGHAN/ESPGHAN 2016 sobre Diagnóstico, Prevención y Tratamiento de Infección por Helicobacter pylori en Pediatría Open
Introducción: Las últimas guías clínicas conjuntas de NASPGHAN y ESPGHAN en relación a la infección por H. pylori publicadas el año 2016, contienen 20 afirmaciones que han sido cuestionadas en la práctica respecto a su aplicabilidad en Lat…
View article: Adaptación a la realidad de Latinoamérica de la Guía Clínica NASPGHAN/ESPGHAN 2016 sobre Diagnóstico, Prevención y Tratamiento de Infección por Helicobacter pylori en Pediatría
Adaptación a la realidad de Latinoamérica de la Guía Clínica NASPGHAN/ESPGHAN 2016 sobre Diagnóstico, Prevención y Tratamiento de Infección por Helicobacter pylori en Pediatría Open
Introducción: Las últimas guías clínicas conjuntas de NASPGHAN y ESPGHAN en relación a la infección por H. pylori publicadas el año 2016, contienen 20 afirmaciones que han sido cuestionadas en la práctica respecto a su aplicabilidad en Lat…
View article: Situación actual del trasplante hepático pediátrico por hepatopatías crónicas en Chile: Inequidades asociadas a la priorización por sistema MELD/PELD
Situación actual del trasplante hepático pediátrico por hepatopatías crónicas en Chile: Inequidades asociadas a la priorización por sistema MELD/PELD Open
Pediatric candidates with chronic liver diseases, especially under two years of age, have greater access difficulties to CLT than adults. Half of the pediatric candidates die on the waiting list before three months. The mortality among can…
View article: Recomendaciones en enfermedad hepática crónica y trasplante hepático durante COVID-19 en pediatría
Recomendaciones en enfermedad hepática crónica y trasplante hepático durante COVID-19 en pediatría Open
El brote del virus SARS-CoV-2 que comenzó a fines del año 2019 en China, se ha expandido a Chile
\ny al mundo rápidamente. Hasta la fecha, en Chile, ha afectado a 18.435 personas con una letalidad
\nen adultos de 1,4%. Los pacientes pediát…
View article: Recomendaciones en enfermedad hepática crónica y trasplante hepático durante COVID-19 en pediatría
Recomendaciones en enfermedad hepática crónica y trasplante hepático durante COVID-19 en pediatría Open
El brote del virus SARS-CoV-2 que comenzó a fines del año 2019 en China, se ha expandido a Chile y al mundo rápidamente. Hasta la fecha, en Chile, ha afectado a 18.435 personas con una letalidad en adultos de 1,4%. Los pacientes pediátrico…
View article: Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis Open
The evidence, obtained from one randomised clinical trial at high risk of bias, is very uncertain on whether sclerotherapy has an influence on mortality and if it may decrease first upper gastrointestinal or oesophageal variceal bleeding i…