Juan Ji An
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View article: Genetic Dissection of BDNF and TrkB Expression in Glial Cells
Genetic Dissection of BDNF and TrkB Expression in Glial Cells Open
The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase receptor B (TrkB) are widely expressed in the central nervous system. It is well documented that neurons express BDNF and full-length Tr…
View article: Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and contextual memory
Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and contextual memory Open
At the center of the hippocampal tri-synaptic loop are synapses formed between mossy fiber (MF) terminals from granule cells in the dentate gyrus (DG) and proximal dendrites of CA3 pyramidal neurons. However, the molecular mechanism regula…
View article: Genetic dissection of BDNF and TrkB expression in glial cells
Genetic dissection of BDNF and TrkB expression in glial cells Open
The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase receptor B (TrkB) are widely expressed in the central nervous system. It is well documented that neurons express BDNF and full-length Tr…
View article: Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis
Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis Open
Significance Neurons in the dorsomedial hypothalamus that express TrkB (DMH TrkB ) have been implicated in the regulation of appetite; however, their relevance to energy expenditure is less clear. This study reveals that activation of DMH …
View article: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits Open
View article: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits Open
The TrkB receptor is critical for the control of energy balance, as mutations in its gene ( NTRK2 ) lead to hyperphagia and severe obesity in humans and mice. The main neural substrate mediating the appetite-suppressing activity of TrkB, h…
View article: TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding
TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding Open
Significance The dorsomedial hypothalamus (DMH) is well known for its role in the regulation of energy expenditure; however, its role in the control of appetite is less defined. Our study identifies TrkB-expressing DMH neurons that potentl…
View article: Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure
Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure Open
View article: Anxiety induced by extra-hypothalamic BDNF deficiency instigates resistance to diet-induced obesity
Anxiety induced by extra-hypothalamic BDNF deficiency instigates resistance to diet-induced obesity Open
SUMMARY Anxiety disorders are associated with body weight changes in humans. However, mechanisms underlying anxiety-related weight changes remain poorly understood. Using Emx1 Cre/+ mice, we deleted the gene for brain-derived neurotrophic …
View article: Anxiety Induced by Extra-Hypothalamic BDNF Deficiency Instigates Resistance to Diet-Induced Obesity
Anxiety Induced by Extra-Hypothalamic BDNF Deficiency Instigates Resistance to Diet-Induced Obesity Open
View article: Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation Open
Huntington's disease (HD) is a neurodegenerative disorder caused by CAG repeat expansion within exon1 of the HTT gene. The gene generates two mRNA variants that carry either a short or long 3' untranslated region (3'UTR) while encoding the…
View article: Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons
Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons Open
Brain-derived neurotrophic factor (BDNF) expressed in the paraventricular hypothalamus (PVH) has been shown to play a key role in regulating energy intake and energy expenditure. BDNF is also expressed in other hypothalamic nuclei; however…
View article: Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure
Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure Open