Explanipedia

Residual myocardial hyperemia in regadenoson stress/rest quantitative perfusion cardiac magnetic resonance Open

Gorka Bastarrika, Ana Ezponda, Javier Muñiz, Marta Vidorreta, Amaia Ochoa González , et al. · 2025

Purpose This study sought to investigate the presence of residual myocardial hyperemia on the recovery phase in patients undergoing stress CMR. Material and methods Fifty patients with clinical indication for stress CMR underwent quantitat…

Melt electrowritten 3D human cardiac engineered tissues reproduce the enhanced sensitivity of fibrotic patients to doxorubicin Open

A Sanchez-Bueno, Asier Ullate‐Agote, Pilar Montero‐Calle, José Valdés‐Fernández, Eduardo Larequi , et al. · 2025

Introduction Cardiotoxicity is a serious and frequent side effect of anthracycline cancer therapy, prompting the cardio-oncologic follow up of patients. However, mechanisms are poorly understood. Moreover, cardiac patients demonstrate an e…

Neo Left Main Creation and Percutaneous Closure of Left Coronary Button Pseudoaneurysm After Bentall Procedure Open

Carlos E. Vergara-Uzcategui, Antonio Martínez-Cuesta, Gorka Bastarrika, Miguel Artaiz, Juán José Gavira , et al. · 2025

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium Open

Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M Rosales, Asier Ullate‐Agote , et al. · 2025

In the heart, the specific 3D structure of myocardial layers produces an efficient ejection of blood. When myocardial infarction strikes, this architecture is disrupted, adding a disarranged contraction to the decreased availability of pum…

Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene Open

Pilar Montero‐Calle, María Flandes‐Iparraguirre, Bernd Kuebler, Begoña Arán, Eduardo Larequi , et al. · 2023

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linke…

Safety, feasibility, and hemodynamic response of regadenoson for stress perfusion CMR Open

Javier Muñiz, Ana Ezponda, Meylin Caballeros, Ana de la Fuente, Juán José Gavira , et al. · 2023

Owing to its pharmacodynamics and posology, the use of regadenoson for stress cardiac magnetic resonance (CMR) has potential advantages over other vasodilators. We sought to evaluate the safety, hemodynamic response and diagnostic performa…

Systemic lupus erythematosus myocarditis after COVID-19 vaccination Open

Miguel Sogbe, Andrés Blanco-Di Matteo, I. Madeleine Di Frisco, Juan Fernando Bastidas, Nahikari Salterain-González , et al. · 2023

Global Circumferential and Radial Strain Among Patients With Immune Checkpoint Inhibitor Myocarditis Open

Thiago Quinaglia, Carlos A. Gongora, Magid Awadalla, Malek Hassan, Amna Zafar , et al. · 2022

Fabrication of human myocardium using multidimensional modelling of engineered tissues Open

Pilar Montero‐Calle, María Flandes‐Iparraguirre, Konstantinos A. Mountris, A Nava, Nicolás Laita , et al. · 2022

Biofabrication of human tissues has seen a meteoric growth triggered by recent technical advancements such as human induced pluripotent stem cells (hiPSCs) and additive manufacturing. However, generation of cardiac tissue is still hampered…

Systemic lupus erythematosus myocarditis after COVID-19 vaccination Open

Miguel Sogbe, Andrés Blanco-Di Matteo, I. Madeleine Di Frisco, Juan Fernando Bastidas, Nahikari Salterain-González , et al. · 2022

A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy Open

Ana de la Fuente, Marta Santisteban, Josep Lupón, José Manuel Aramendía, A. Fernández-Mardomingo Díaz , et al. · 2022

Anthracycline-based cancer chemotherapy (ACC) causes myocardial fibrosis, a lesion contributing to left ventricular dysfunction (LVD). We investigated whether the procollagen-derived type-I C-terminal-propeptide (PICP): (1) associates with…

Regadenoson stress CMR: safety, feasibility and hemodynamic response Open

Javier Muñiz, Ana Ezponda, Juán José Gavira, Alba Riesgo, O Shanhutov , et al. · 2021

Background and objectives The use of regadenoson for stress cardiac magnetic resonance (CMR) has potential advantages over other vasodilators. We sought to evaluate the safety, feasibility and hemodynamic response (heart rate and blood pre…

Preclinical Evaluation of the Safety and Immunological Action of Allogeneic ADSC-Collagen Scaffolds in the Treatment of Chronic Ischemic Cardiomyopathy Open

Ascensión López-Dı́az de Cerio, Iñigo Perez-Estenaga, Susana Inogès, Gloria Abizanda, Juán José Gavira , et al. · 2021

The use of allogeneic adipose-derived mesenchymal stromal cells (alloADSCs) represents an attractive approach for treating myocardial infarction (MI). Furthermore, adding a natural support improves alloADSCs engraftment and survival in hea…

Resección de válvula aórtica transcatéter tras 8 años desde la implantación y sustitución por bioprótesis aórtica Open

Rebeca Manrique, N Salterain, Elena Cánovas Méndez, Juán José Gavira, María Josefa Iribarren , et al. · 2021

Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor–Associated Myocarditis Open

Paaladinesh Thavendiranathan, Lili Zhang, Amna Zafar, Zsófia D. Drobni, Syed Mahmood , et al. · 2021

Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction Open

Adrián Ruiz‐Villalba, Juan P. Romero, Silvia C. Hernández, Amaia Vilas‐Zornoza, Nikolaus Fortelny , et al. · 2020

Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process associated with different types of fibrosis. Recent studies have shown that fibroblasts do not respond homogeneously to heart injury. Because o…

Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering Open

Pilar Montero-Alía, María Flandes‐Iparraguirre, Saioa Musquiz, Maria Pérez-Araluce, Daniel Plano , et al. · 2020

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI) responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity, added to the deleterious remodelling programme set into m…

Does Chronic Kidney Disease Facilitate Malignant Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction of Hypertensive Origin? Open

Rocío Eirós, Gregorio Romero‐González, Juán José Gavira, Óscar Beloqui, Inmaculada Colina , et al. · 2020

In hypertensive patients with heart failure (HF) a serum biomarker combination of high carboxy-terminal propeptide of procollagen type-I (PICP) and low carboxy-terminal telopeptide of collagen type-I to matrix metalloproteinase-1 (CITP:MMP…

P677 When to look for wtTTR amyloidosis in heart failure: increasing chances of positive gammagraphic study Open

J Ibero, Alba Riesgo, Macarena Rodríguez‐Fraile, M. Morales, Juan-Carlos Muniz , et al. · 2020

Introduction Wild type transtirretin (wtATTR) amyloidosis has become increasingly recognized as a major cause for heart failure (HF). Diagnosis requires complex work up such as DPD scintigraphy (DPDs). Availability of DPDs is limited urgin…

Severe Cardiac and Abdominal Manifestations Without Lung Involvement in a Child With COVID-19 Open

Miriam Gutiérrez-Jimeno, Adriana Ibanez Sada, Juán José Gavira, Carolina Cebrian-Nebot, Laura Martin Lopez , et al. · 2020

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic, affecting humans of all ages. Clinical features of the pediatric population have been published, but there is not yet enough information to make a definitive description.…

P185 Primary cardiac lymphoma: an unexpected finding Open

Alba Riesgo, J Ibero, Macarena Rodríguez‐Fraile, F Torre, Juan-Carlos Muniz , et al. · 2020

BACKGROUND Primary cardiac malignancies are rare, with a reported incidence of 0.1%. Up to 10% of cardiac tumors are malignant and primary cardiac lymphoma represents (PCL) a very low proportion of them. The wide variety of clinical manife…

Single-cell RNA-seq analysis reveals the crucial role of Collagen Triplex Helix Repeat Containing 1 (CTHRC1) cardiac fibroblasts for ventricular remodeling after myocardial infarction Open

Adrián Ruiz‐Villalba, Juan P. Romero, Silvia C. Hernández, Amaia Vilas‐Zornoza, Nikolaus Fortelny , et al. · 2019

Cardiac fibroblasts have a central role during the ventricular remodeling process associated with different types of cardiac injury. Recent studies have shown that fibroblasts do not respond homogeneously to heart damage, suggesting that t…

P5676Safety and immunomodulatory action of epicardial patches combined with allogeneic adipose-derived mesenchymal stem cells in a rodent and porcine model of myocardial infarction Open

Beatriz Pelacho, Ascensión López-Dı́az de Cerio, Susana Inogès, I Perez-Astenaga, Juán José Gavira , et al. · 2018

Regeneración miocárdica: el futuro al alcance de la mano Open

Juán José Gavira, E Alegría, Antonio Arnau, Gloria Abizanda, M. Pérez-Ilzarbe , et al. · 2017

En los últimos años hemos asistido a un interés creciente por el tratamiento de la insuficiencia cardíaca mediante el trasplante de células madre. Mientras que los estudios con células madre de músculo (mioblastos) se iniciaron hace mas de…

Arritmias supvaventriculares. Posibles aplicaciones del esmolol. Open

Juan Cosı́n-Sales, Alfonso Macı́as, Juán José Gavira, Cristina Honorato‐Cia, Gregorio Rábago , et al. · 2017

Dentro de las arritmias supraventriculares podemos encontrar a la fibrilación auricular, el fluter, las taquicardias paroxísticas supraventriculares y las taquicardias auriculares. La más frecuente es la fibrilación auricular. En la presen…

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury Open

María Collantes, Beatriz Pelacho, María José García-Velloso, Juán José Gavira, Gloria Abizanda , et al. · 2017

PET/CT imaging of ¹⁸F-FDG-labeled CSC allows quantifying biodistribution and acute retention of implanted cells in a clinically relevant pig model of chronic myocardial infarction. Similar levels of acute retention are achieved …

Benefit of tolvaptan in the management of hyponatraemia in patients with diuretic‐refractory congestive heart failure: the SEMI‐SEC project Open

Antonio Pose, Luís Almenar, Juán José Gavira, Amador López‐Granados, Teresa Blasco , et al. · 2017

Aims Hyponatraemia is an electrolyte disorder that occurs in advanced congestive heart failure (HF) and worsens prognosis. We explored the usefulness of tolvaptan, which has shown promising results in the treatment of this condition. Metho…

Catheter-based Intramyocardial Injection of FGF1 or NRG1-loaded MPs Improves Cardiac Function in a Preclinical Model of Ischemia-Reperfusion Open

Elisa Garbayo, Juán José Gavira, M. Castro, Beatriz Pelacho, Gloria Abizanda , et al. · 2016

Cardiovascular protein therapeutics such as neuregulin (NRG1) and acidic-fibroblast growth factor (FGF1) requires new formulation strategies that allow for sustained bioavailability of the drug in the infarcted myocardium. However, there i…

Primary Prevention of Sudden Cardiac Death in Patients with Heart Failure: How Effective is Current Pharmacologic Therapy? Open

Juán José Gavira, Ignacio García Bolao, Javier Dı́ez · 2016

Sudden cardiac death is the most common cause of death in the early stages of heart failure.Implantable cardioverter-defibrillator therapies substantially reduce sudden cardiac death but incur morbidity and are expensive, so are recommende…

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