Juan M. Colazo
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View article: siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs
siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs Open
View article: Development of a Cutting Guide for Osteocutaneous Radial Forearm Free Flap Harvest
Development of a Cutting Guide for Osteocutaneous Radial Forearm Free Flap Harvest Open
Objectives The osteocutaneous radial forearm free flap (OCRFFF) is used for the reconstruction of bony head and neck defects. Being a weight‐bearing bone, precise harvesting of the radius is required to maintain structural integrity, posto…
View article: Is posterior cervical imbalance after anterior cervical discectomy with fusion a determinant in the development of adjacent cervical degeneration? A retrospective study with an average of 8 years of follow-up
Is posterior cervical imbalance after anterior cervical discectomy with fusion a determinant in the development of adjacent cervical degeneration? A retrospective study with an average of 8 years of follow-up Open
Aims: The primary objective of this study is to evaluate the hypotheses that postoperative sagittal imbalance influences the development of adjacent segment degeneration (ASDeg) in patients who have undergone an anterior cervical discectom…
View article: A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine Open
View article: Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy Open
The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetic…
View article: An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) Open
View article: A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine Open
Objective Investigational cell therapies have been developed as disease-modifying agents for the treatment of osteoarthritis (OA), including those that inducibly respond to inflammatory factors driving OA progression. However, dysregulated…
View article: Engineering approaches for RNA-based and cell-based osteoarthritis therapies
Engineering approaches for RNA-based and cell-based osteoarthritis therapies Open
View article: ASO Author Reflections: 3D Specimen Scanning in Musculoskeletal Oncology
ASO Author Reflections: 3D Specimen Scanning in Musculoskeletal Oncology Open
View article: Utility of iliac crest tetracycline-labelled bone biopsy in osteoporosis and metabolic bone disease: An evaluation of 95 cases over a period of 25 years
Utility of iliac crest tetracycline-labelled bone biopsy in osteoporosis and metabolic bone disease: An evaluation of 95 cases over a period of 25 years Open
Tetracycline-labelled bone biopsies are under-utilized. Biopsy led to a histological diagnosis and ensuing treatment alteration in most patients with significant increases in bone mineral density. The biopsy procedure used herein provided …
View article: Nonviral <i>In Vivo</i> Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles
Nonviral <i>In Vivo</i> Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles Open
The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge, efficiently load into porous silicon nanoparticles…
View article: Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis
Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis Open
Osteoarthritis (OA) and rheumatoid arthritis (RA) are joint diseases that are associated with pain and lost quality of life. No disease modifying OA drugs are currently available. RA treatments are better established but are not always eff…
View article: Augmented-Reality Surgery to Guide Head and Neck Cancer Re-resection: A Feasibility and Accuracy Study
Augmented-Reality Surgery to Guide Head and Neck Cancer Re-resection: A Feasibility and Accuracy Study Open
View article: Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase
Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase Open
View article: Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy Open
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized for in situ binding to album…
View article: Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis
Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis Open
A 74-year-old man with a medical history significant for papillary thyroid cancer (PTC) presented with a rapidly enlarging grape-sized mass in his right medial arm with paresthesia in the ulnar nerve distribution. Imaging was suspicious fo…
View article: Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair
Reactive oxygen species–degradable polythioketal urethane foam dressings to promote porcine skin wound repair Open
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic biomaterials are less expensive to manufacture than biologic dressings a…
View article: Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch
Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch Open
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferativ…
View article: Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis
Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis Open
Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here, prolonged RNA interference (RNAi) of matrix metal…
View article: Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage Open
View article: Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis
Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis Open
Osteoarthritis (OA) is treated with the intra-articular injection of steroids such as dexamethasone (DEX) to provide short-term pain management. However, DEX treatment suffers from rapid joint clearance. Here, 20 × 10 μm, shape-defined pol…
View article: Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation
Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation Open
Summary paragraph Chronic inflammation underlies the onset, progression and associated pain of numerous diseases.( 1 ) Current anti-inflammatory treatments administered systemically are associated with moderate-to-severe side effects, whil…
View article: The Paramedian Forehead Flap: A Retrospective Clinical Model for Understanding the Connection Between Supraorbital and Supratrochlear Nerve Pathology and Headaches
The Paramedian Forehead Flap: A Retrospective Clinical Model for Understanding the Connection Between Supraorbital and Supratrochlear Nerve Pathology and Headaches Open
Background: In the later stages of a paramedian forehead flap (PMFF) surgery, the supratrochlear (STN) and branches of the supraorbital nerve (SON) are transected during flap inset above the supraorbital rim. This can lead to either a nerv…
View article: Hiding in plain sight: Gene panel and genetic markers reveal 26-year undiagnosed tumor-induced osteomalacia of the rib concurrently misdiagnosed as X-linked hypophosphatemia
Hiding in plain sight: Gene panel and genetic markers reveal 26-year undiagnosed tumor-induced osteomalacia of the rib concurrently misdiagnosed as X-linked hypophosphatemia Open
Tumor-induced osteomalacia (TIO), caused by phosphaturic mesenchymal tumors (PMTs), is a rare paraneoplastic syndrome characterized by frequent bone fractures, bone pain, muscle weakness, and affected gait. These tumors typically secrete h…
View article: Characterization of physical, functional, and cognitive performance in 15 adults with hypophosphatasia
Characterization of physical, functional, and cognitive performance in 15 adults with hypophosphatasia Open
Objective functional assessments demonstrated defects in physical functioning, including decreased ability to walk distances, slow gait speed, and diminished ability to repeatedly rise from a sitting position. In addition, participants sel…
View article: A Basis to Be Here: Stories from International Graduate Students in the United States
A Basis to Be Here: Stories from International Graduate Students in the United States Open
Recent guidance from the US Immigration and Customs Enforcement drastically altered the lives of international students in America, especially those who are matriculating. This commentary describes how international students still face unc…
View article: Abstract QS28: Unnecessary Interfacility Transfers For Craniomaxillofacial Trauma
Abstract QS28: Unnecessary Interfacility Transfers For Craniomaxillofacial Trauma Open
Purpose: Patients with CMF injuries are frequently transferred for specialist evaluation. Although transfer guidelines have improved outcomes for trauma care, no standards exist for CMF injuries. As a result, many patients are unnecessaril…
View article: Reconstruction of Upper Third Ear Defects: Utility of a Limited Tanzer Reduction
Reconstruction of Upper Third Ear Defects: Utility of a Limited Tanzer Reduction Open
The proposed limited Tanzer reduction technique was shown to be a safe, viable, functionally and aesthetically pleasing option for the reconstruction of large defects of the ear and thus should be part of the armamentarium of the reconstru…
View article: An intracranial mass causing tumor-induced osteomalacia (TIO): Rapid and complete resolution of severe osteoporosis after surgical resection
An intracranial mass causing tumor-induced osteomalacia (TIO): Rapid and complete resolution of severe osteoporosis after surgical resection Open
View article: Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis
Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis Open
Osteoarthritis (OA) is a debilitating and prevalent chronic disease, but there are no approved disease modifying OA drugs (DMOADs), only pharmaceuticals for pain management. OA progression, particularly for post-traumatic osteoarthritis (P…