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Transcriptomic profiling of thrombus-derived extracellular vesicles reveals PECAM-1 as a potential inflammatory marker for cardioembolic stroke patients Open

Florencio J. D. Machado, Juan Marta-Enguita, María Herrera, Javier Marta-Moreno, José A. Páramo , et al. · 2025

Accurate etiological diagnosis ensures appropriate secondary prevention of ischemic stroke (IS) patients. However, about 25–40% of IS cases remain of undetermined origin (referred to as ESUS if an unknown embolic source is suspected), high…

The role of endothelial dysfunction in the age-related poor prognosis of stroke patients undergoing endovascular treatment Open

Patricia de la Riva, J. Muñoz, Juan Marta-Enguita, V. Gómez, Gorka Arenaza , et al. · 2025

A total of 150 stroke patients were included in the analysis (median age was 77 years and 50.7 % were female). Older patients exhibited poorer endothelial function, reflected by lower FMD values and altered arginine metabolite profiles. Th…

Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments Open

Juan Marta-Enguita, Florencio J. D. Machado, Josune Orbe, Roberto Muñoz · 2024

Understanding of thrombus components and mechanisms involved in thrombus formation represent a potential pathway for the development of ischaemic stroke therapeutics with promising perspectives.

20779. OPTIMIZACIÓN DE ALGORITMO DE INDICACIÓN DE MONITORIZACIÓN HOLTER PROLONGADA EN DOMICILIO TRAS ICTUS CRIPTOGÉNICO-ESUS Open

Juan Marta-Enguita, Patricia de la Riva, A. de Arce Borda, N. Díez González, Francisca López , et al. · 2024

20919. ICTUS ISQUÉMICO POR EMBOLISMO TUMORAL COMO DEBUT DE UN ADENOCARCINOMA DE PULMÓN Open

Ignacio Gómez, C. Jauregui Larrañaga, G. Núñez Manjarres, A. Val-Carreres Castellote, Sónia González , et al. · 2024

20986. ANGIOPATÍA AMILOIDE CEREBRAL EN MENORES DE 55 AÑOS CON HEMORRAGIA INTRAPARENQUIMATOSA EN UNA COHORTE HOSPITALARIA Open

Ignacio Gómez, L. Narraspe, Patricia de la Riva, G. Núñez Manjarres, Juan Marta-Enguita , et al. · 2024

21026. ANÁLISIS DE INFLUENCIA DEL NÚMERO DE PASES EN EFICACIA Y SEGURIDAD DEL TRATAMIENTO ENDOVASCULAR EN EL ICTUS ISQUÉMICO Open

Juan Marta-Enguita, Patricia de la Riva, A. de Arce Borda, N. Díez González, Francisca López , et al. · 2024

21024. ANÁLISIS DE PREDICTORES DE FA EN PACIENTES CON ICTUS ISQUÉMICO ASOCIADO A CREACIÓN DE ALGORITMO DE DECISIÓN BASADO EN MACHINE LEARNING Open

Juan Marta-Enguita, Patricia de la Riva, A. de Arce Borda, N. Díez González, Francisca López , et al. · 2024

Understanding Endothelial Dysfunction and Its Role in Ischemic Stroke After the Outbreak of Recanalization Therapies Open

Patricia de la Riva, Juan Marta-Enguita, J. Muñoz, Alberto Bergareche, Adolfo López de Munaín · 2024

Despite recent advances in treatment options, stroke remains a highly prevalent and devastating condition with significant socioeconomic impact. Recanalization therapies, including intravenous thrombolysis and endovascular treatments, have…

Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies Open

Florencio J. D. Machado, Juan Marta-Enguita, Susan U. Gómez, José Antonio Rodríguez, José A. Páramo , et al. · 2024

Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomi…

Composición del trombo e implicaciones en la caracterización y el tratamiento en el ictus isquémico Open

Juan Marta-Enguita, Florencio J. D. Machado, Josune Orbe, Roberto Muñóz · 2024

Resumen: Introducción: La obtención del material trombótico en el ictus isquémico desde la generalización de la trombectomía mecánica ha permitido un estudio exhaustivo del mismo y de los posibles mecanismos fisiopatológicos subyacentes a …

Role of factor XIII in ischemic stroke: a key molecule promoting thrombus stabilization and resistance to lysis Open

Juan Marta-Enguita, Manuel Navarro-Oviedo, Florencio J. D. Machado, Rebeca Bermejo, N. Aymerich , et al. · 2023

Our results suggest a key role of FXIIIa in thrombus stabilization, α2AP crosslinking, and lysis resistance, with a protective effect of FXIIIinh in an IS experimental model.

Analysis of the prognostic value of emergency blood tests in ischaemic stroke Open

Juan Marta-Enguita, I. Rubio-Baines, N. Aymerich, Mariana Herrera Piñero, Beatriz Zandio , et al. · 2022

Basic blood test parameters provide important prognostic information for stroke patients and should therefore be analysed in combination with standard clinical and radiological parameters to optimise ischaemic stroke management.

Análisis del valor pronóstico de la analítica urgente en el ictus isquémico Open

Juan Marta-Enguita, I. Rubio-Baines, N. Aymerich, Mariana Herrera, Beatriz Zandio , et al. · 2022

Este estudio busca identificar el potencial pronóstico de los parámetros de la analítica urgente en pacientes con ictus isquémico. Se recogió prospectivamente a 592 pacientes con evento isquémico cerebral confirmado por neuroimagen, atendi…

Impact on functional outcome of an adaptive Stroke Unit based system of care for patients undergoing endovascular treatment during pandemic times Open

Jon Equiza, Patricia de la Riva, José Ángel Larrea, Juan Marta-Enguita, Inés Albájar , et al. · 2022

Introduction: The COVID19 pandemic collapsed intensive care units (ICUs) all around the world, conditioning systems of care (SOC) for other critical conditions such as severe ischemic stroke requiring endovascular treatment (EVT). Our aim …

CM-352 Efficacy in a Mouse Model of Anticoagulant-Associated Intracranial Hemorrhage Open

Manuel Navarro-Oviedo, Juan Marta-Enguita, Carmen Roncal, José Antonio Rodríguez, Beatriz Zandio , et al. · 2022

Background Intracranial hemorrhage (ICH) is one of the major devastating complications of anticoagulation. Matrix metalloproteinase (MMP) inhibition has been proposed as a novel pharmacological approach for ICH treatment. Objectives We eva…

Repercusión de la pandemia por COVID-19 en la formación de los residentes de neurología españoles Open

D.M. Cerdán Santacruz, Susana Arias-Rivas, Pablo Eguia del Rio, Francisco Escamilla‐Sevilla, D. Ezpeleta Echávarri , et al. · 2021

Inside the Thrombus: Association of Hemostatic Parameters With Outcomes in Large Vessel Stroke Patients Open

Juan Marta-Enguita, Manuel Navarro-Oviedo, Roberto Muñóz, Jorge Olier-Arenas, Guillermo Zalba , et al. · 2021

Background: Actual clinical management of ischemic stroke (IS) is based on restoring cerebral blood flow using tissue plasminogen activator (tPA) and/or endovascular treatment (EVT). Mechanical thrombectomy has permitted the analysis of th…

Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke Open

Juan Marta-Enguita, Manuel Navarro-Oviedo, I. Rubio-Baines, N. Aymerich, María Herrera , et al. · 2021

Impact of COVID‐19 outbreak in reperfusion therapies of acute ischaemic stroke in northwest Spain Open

H. Tejada Meza, Álvaro Lambea‐Gil, A. Sancho Saldaña, Maite Martínez-Zabaleta, Eñaut Garmendia Lopetegui , et al. · 2020

Background and purpose Spain has been one of the countries more heavily stricken by SARS‐CoV‐2, which has had huge implications for stroke care. The aim was to analyse the impact of the COVID‐19 epidemic outbreak on reperfusion therapies f…

Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage Open

Manuel Navarro-Oviedo, Roberto Muñóz, Beatriz Zandio, Juan Marta-Enguita, Anna Bonaterra‐Pastra , et al. · 2020

Factores de riesgo y predictores de gravedad en pacientes hospitalizados por COVID-19: análisis de 52 casos Open

Juan Marta-Enguita, Jon Corroza-Laviñeta, Aiora Ostolaza · 2020

Calprotectin predicts mortality after ischemic stroke and is present in the thrombus Open

Juan Marta-Enguita, Manuel Navarro-Oviedo, I. Rubio-Baines, N. Aymerich, María Herrera , et al. · 2020

Background- Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein in the regulation of inflammation and…

Impact of COVID-19 outbreak on ischemic stroke admissions and in-hospital mortality in North-West Spain Open

H. Tejada Meza, Álvaro Lambea‐Gil, A. Sancho Saldaña, Maite Martínez-Zabaleta, Patricia de la Riva , et al. · 2020

Background and purpose Spain has been one of the countries heavily stricken by COVID-19. But this epidemic has not affected all regions equally. We analyzed the impact of the COVID-19 pandemic on hospital stroke admissions and in-hospital …

Fatal Guillain-Barre syndrome after infection with SARS-CoV-2 Open

Juan Marta-Enguita, I. Rubio-Baines, I. Gastón-Zubimendi · 2020

Síndrome de Guillain-Barré fatal tras infección por el virus SARS-CoV-2 Open

Juan Marta-Enguita, I. Rubio-Baines, I. Gastón-Zubimendi · 2020

Trombo Flotante en Arteria Carótida Open

Juan Marta-Enguita, Roberto Muñóz · 2020

Trombo Flotante en

Casuística de códigos ictus atendidos por 061 ARAGÓN en el período 2010-2016. Factores que influyen en los tiempos de respuesta y de acceso a la fibrinólisis Open

M L Muñío-Iranzo, Juan Marta-Enguita, Javier Marta-Moreno, Àngel Gasch‐Gallén, M Sampériz-Murillo · 2019

In 55,3% of patients, the 061 response time was greater than 60 minutes, but this time were not conditioned by the activation time. However, there were differences in the percentage of cases fibrinolysed in the different time intervals, su…

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