Juan F. Navarro‐González
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View article: Systemic inflammatory profiles are associated with long-term kidney failure and patient mortality in chronic kidney disease
Systemic inflammatory profiles are associated with long-term kidney failure and patient mortality in chronic kidney disease Open
Background Chronic kidney disease (CKD) is frequently associated with systemic inflammation. However, the relationship between inflammatory cytokines and CKD progression remains incompletely understood. Methods The PROGRESER study was a mu…
View article: Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed
Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed Open
Diabetes mellitus (DM) continues to be a global world health problem. Despite medical advances, both DM and chronic kidney disease (CKD) remain global health issues with high mortality and limited options to prevent end-stage renal failure…
View article: Sex differences in the prognostic value of urinary albumin-to-creatinine ratio for coronary artery disease and cardiovascular events in people with type 2 diabetes and normoalbuminuria
Sex differences in the prognostic value of urinary albumin-to-creatinine ratio for coronary artery disease and cardiovascular events in people with type 2 diabetes and normoalbuminuria Open
View article: Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed
Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed Open
Diabetes mellitus (DM) continuous to be a global world health problem. The Athlas of the International DM Federation for 2023 estimated that 589 million adults (20-79 years) are living with DM and this number could increase to 853 million …
View article: Predicting CKD in Type 2 Diabetes Using Natural Language Processing on Healthcare Data
Predicting CKD in Type 2 Diabetes Using Natural Language Processing on Healthcare Data Open
Background: Persons with type 2 diabetes mellitus (T2DM) attending hospitals frequently experience major complications. We assessed the potential use of unstructured free-text data extracted from electronic health records (EHRs) using natu…
View article: Current insights and challenges in the management of hyperkalemia
Current insights and challenges in the management of hyperkalemia Open
Hyperkalemia is an electrolyte disorder characterized by elevated serum potassium levels, which can be dangerous and lead to severe cardiac complications. This condition is particularly common in patients with comorbidities such as diabete…
View article: #3196 Inflammatory cytokine clusters are associated with adverse outcomes in patients with CKD
#3196 Inflammatory cytokine clusters are associated with adverse outcomes in patients with CKD Open
Background and Aims Chronic kidney disease (CKD) is one of the fastest growing global causes of death, characterized by a gradual loss of renal function over time leading to kidney failure. Early detection of progression and treatment are …
View article: Non-Inferiority Study of Two Capsaicin Formulations for Painful Diabetic Neuropathy
Non-Inferiority Study of Two Capsaicin Formulations for Painful Diabetic Neuropathy Open
While capsaicin topical formulations are established treatments, conventional creams using this substance have limited application due to handling-related adverse events. This study aimed to demonstrate that the efficacy of a novel 0.75 mg…
View article: Prospective evaluation of CAR-T cell therapy-related proteinuria and kidney dysfunction
Prospective evaluation of CAR-T cell therapy-related proteinuria and kidney dysfunction Open
Background The nephrotoxicity of chimeric antigen receptor T-cell (CAR-T) therapy has been reported, yet data on urinary abnormalities remain limited. This study aimed to characterize proteinuria, acute kidney injury (AKI), and associated …
View article: Targeting Sarcopenia in CKD: The Emerging Role of GLP-1 Receptor Agonists
Targeting Sarcopenia in CKD: The Emerging Role of GLP-1 Receptor Agonists Open
Sarcopenia is a prevalent and disabling complication of chronic kidney disease (CKD), associated with frailty, diminished quality of life, and increased morbidity and mortality. Despite its clinical significance, no pharmacological treatme…
View article: Expression of ADAM17 and serum PTH levels in dialysis patients with and without diabetes: Potential implications for vascular calcification
Expression of ADAM17 and serum PTH levels in dialysis patients with and without diabetes: Potential implications for vascular calcification Open
Although changes in ADAM17 and TIMP3 gene expression were observed in diabetic patients, potentially related to increased synthesis and/or release of pro-inflammatory factors, these do not appear to explain the difference in mortality asso…
View article: “Inside CKD” Multinational-Microsimulation Modelling Insights Into the Increasing CKD Burden
“Inside CKD” Multinational-Microsimulation Modelling Insights Into the Increasing CKD Burden Open
Implementing screening and treatment strategies will be crucial for the early identification of CKD and for overcoming the current clinical inertia around the diagnosis and management of CKD.
View article: Expresión de ADAM17 y niveles de PTH sérica en pacientes con y sin diabetes en diálisis: posibles implicaciones en la calcificación vascular
Expresión de ADAM17 y niveles de PTH sérica en pacientes con y sin diabetes en diálisis: posibles implicaciones en la calcificación vascular Open
View article: Clinical Practice Guideline for detection and management of diabetic kidney disease: A consensus report by the Spanish Society of Nephrology
Clinical Practice Guideline for detection and management of diabetic kidney disease: A consensus report by the Spanish Society of Nephrology Open
To address all the changes in the management of people with diabetes (DM) and chronic kidney disease (CKD), under the auspices of the Spanish Society of Nephrology (SEN), the Spanish Diabetic Nephropathy Study Group (GEENDIAB) decided to p…
View article: In response to optimizing osteoporosis management in CKD patients
In response to optimizing osteoporosis management in CKD patients Open
View article: Nomenclature of renal involvement in diabetes mellitus: unify to manage diversity
Nomenclature of renal involvement in diabetes mellitus: unify to manage diversity Open
Diabetes mellitus is the most common cause of chronic kidney disease leading to kidney failure and premature death. Over the years, the nomenclature of kidney involvement in diabetes mellitus has evolved, driven both by the understanding t…
View article: In response to optimizing osteoporosis management in CKD patients
In response to optimizing osteoporosis management in CKD patients Open
View article: Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events Open
This retrospective study demonstrates significant associations between the TyG index and the occurrence and severity of CAD, as well as indicates the clinical value of the TyG index as a potential predictor for MACE.
View article: Guía de práctica clínica sobre detección y manejo de la enfermedad renal diabética: documento de consenso de la Sociedad Española de Nefrología
Guía de práctica clínica sobre detección y manejo de la enfermedad renal diabética: documento de consenso de la Sociedad Española de Nefrología Open
Resumen: Para abordar todas las novedades en el manejo de las personas con diabetes mellitus (DM) y enfermedad renal crónica (ERC), el Grupo Español de Estudio de Nefropatía Diabética (GEENDIAB) bajo los auspicios de la Sociedad Española d…
View article: Differences in association between hypoalbuminaemia and mortality among younger versus older patients on haemodialysis
Differences in association between hypoalbuminaemia and mortality among younger versus older patients on haemodialysis Open
Background Ageing often affects biomarker production. Yet, clinical/optimal thresholds to guide clinical decisions do not consider this. Serum albumin decreases with age, but hypoalbuminaemia is defined as serum albumin <4.0 g/dl. This …
View article: Evaluation of clinical events and costs associated with the addition of dapagliflozin to chronic kidney disease treatment: Cost offset analysis
Evaluation of clinical events and costs associated with the addition of dapagliflozin to chronic kidney disease treatment: Cost offset analysis Open
Delaying progression of CKD and reducing the incidence of clinical events thanks to the treatment with dapagliflozin could generate savings for the Spanish National Health System, even when pharmacological costs are taken into account.
View article: Projection of the clinical and economic burden of chronic kidney disease between 2022 and 2027 in Spain: Results of the Inside CKD project
Projection of the clinical and economic burden of chronic kidney disease between 2022 and 2027 in Spain: Results of the Inside CKD project Open
The Inside CKD project highlights the growing clinical, economic and social burden of CKD in Spain expected by 2027. Progression to more advanced stages with the need for RRT and associated complications represent a small proportion of the…
View article: Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories
Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories Open
This study highlights the disproportionate population-level clinical and economic burden associated with individuals within KDIGO uACR categories A1 and A2, who represent most of the CKD population. This awareness will help health care dec…
View article: Risk factors for progression in patients with KDOQI stage 3 Chronic Kidney Disease (PROGRESER study)
Risk factors for progression in patients with KDOQI stage 3 Chronic Kidney Disease (PROGRESER study) Open
in our study we have not found new factors for progression of renal damage, different from the yet well known traditional factors. DM "per se" was not a differential factor for progression in relation with non DM patients. Progression of r…
View article: Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial
Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial Open
The study protocol code is PTF-AA-TR-2009 and the trial was registered on the European Union Drug Regulating Authorities Clinical Trials (EudraCT #2009-016595-77). The validation date was 2010-03-09.
View article: Pentoxifylline Ameliorates Subclinical Atherosclerosis Progression in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Randomized Pilot Trial
Pentoxifylline Ameliorates Subclinical Atherosclerosis Progression in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Randomized Pilot Trial Open
Background: Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and antifibrotic action…
View article: Evaluación de eventos clínicos y costes asociados a la adición de dapagliflozina al tratamiento de la enfermedad renal crónica: análisis de compensación de costes
Evaluación de eventos clínicos y costes asociados a la adición de dapagliflozina al tratamiento de la enfermedad renal crónica: análisis de compensación de costes Open
Antecedentes y objetivos: La enfermedad renal crónica (ERC) es un grave problema de salud cuyo impacto clínico, social y económico se incrementa en estadios avanzados. Dapagliflozina es un inhibidor del cotransportador de sodio-glucosa-2 q…
View article: FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease
FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease Open
Fibroblast growth factor 23 (FGF23) levels are often elevated in chronic kidney disease (CKD). FGF23 and inflammation are common characteristics in CKD, and both are associated with worse disease progression and the occurrence of complicat…
View article: #2009 FGF23 in patients with diabetic kidney disease and atherosclerosis
#2009 FGF23 in patients with diabetic kidney disease and atherosclerosis Open
Background and Aims Diabetes mellitus (DM) and chronic kidney disease (CKD) are risk factors for vascular atherosclerosis, a pathological process with an important inflammatory component. The coexistence of these conditions in patients wit…
View article: #2775 ERCOS multicenter Spanish study: clinical profile of patients with chronic kidney disease G3a-G5D and osteoporosis
#2775 ERCOS multicenter Spanish study: clinical profile of patients with chronic kidney disease G3a-G5D and osteoporosis Open
Background and Aims Fracture risk evaluation has recently been integrated into the 2017 KDIGO CKD-MBD (Chronic Kidney Disease- Mineral and Bone Disorder) guideline and its 2021 Spanish endorsement. It is now suggested to test bone mineral …