Juan Suárez
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View article: A synergic GLP-1/Acylethanolamide-based combined therapy for MAFLD: Studies in rat models
A synergic GLP-1/Acylethanolamide-based combined therapy for MAFLD: Studies in rat models Open
Obesity remains a major epidemic in developed countries, with metabolic-associated fatty liver disease (MAFLD) as one of its main hepatic consequences. Pharmacological treatments for MAFLD are limited, but modulation of glucagon-like pepti…
View article: Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer’s Disease
Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer’s Disease Open
Background and Objective: Humanized models of Alzheimer’s disease (AD) provide valuable tools for investigating the mechanisms of this neurodegenerative disorder, the leading cause of dementia. These models enable the study of AD progressi…
View article: Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances
Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances Open
View article: Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner
Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner Open
Background Certain events that occur in early life, such as changes in nutrition, can promote structural and functional modifications in brain development, projecting to either short, medium, and/or long terms, resulting in metabolic progr…
View article: Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus Open
Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the brain. This study investigates the pharmacological effects of 14-day repeated intrape…
View article: En camino de proyectar experiencias, saberes y conocimientos desde los RSU
En camino de proyectar experiencias, saberes y conocimientos desde los RSU Open
La ausencia de una cultura sólida de sistematización en la Facultad de Ciencias Sociales y Humanas (FCSH) en la Universidad Surcolombiana ha dificultado la evaluación integral de sus proyectos de Responsabilidad Social Universitaria (RSU).…
View article: Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease
Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease Open
View article: Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis
Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis Open
Background/Objectives: Alzheimer’s disease (AD), a leading cause of dementia, lacks effective long-term treatments. Current therapies offer temporary relief or fail to halt its progression and are often inaccessible due to cost. AD involve…
View article: Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review
Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review Open
View article: Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments Open
View article: Hydroxytyrosol Linoleoyl Ether Ameliorates Metabolic-Associated Fatty Liver Disease Symptoms in Obese Zucker Rats
Hydroxytyrosol Linoleoyl Ether Ameliorates Metabolic-Associated Fatty Liver Disease Symptoms in Obese Zucker Rats Open
A main hepatic consequence of obesity is metabolic-associated fatty liver disease (MAFLD), currently treated by improving eating habits and administrating fibrates yet often yielding suboptimal outcomes. Searching for a new therapeutic app…
View article: Dental color measurement to estimate age in adults: a systematic review and meta-analysis
Dental color measurement to estimate age in adults: a systematic review and meta-analysis Open
Age estimation is a major challenge in anthropology and forensic odontology laboratories, as well as in judicial settings, as one of the tools used in human identification. The aim of this study was to evaluate the usefulness of age estima…
View article: Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study
Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study Open
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in t…
View article: Inhibition of Adult Neurogenesis in Male Mice after Repeated Exposure to Paracetamol Overdose
Inhibition of Adult Neurogenesis in Male Mice after Repeated Exposure to Paracetamol Overdose Open
Paracetamol, or acetaminophen (N-acetyl-para-aminophenol, APAP), is an analgesic and antipyretic drug that is commonly used worldwide, implicated in numerous intoxications due to overdose, and causes serious liver damage. APAP can cross th…
View article: Vulnerability of the Critically Endangered leatherback turtle to fisheries bycatch in the eastern Pacific Ocean. II. Assessment of mitigation measures
Vulnerability of the Critically Endangered leatherback turtle to fisheries bycatch in the eastern Pacific Ocean. II. Assessment of mitigation measures Open
Industrial tuna and artisanal fisheries targeting multiple species in the eastern Pacific Ocean (EPO) interact with the Critically Endangered East Pacific (EP) leatherback turtle Dermochelys coriacea . In 2021, a revised Inter-American Tro…
View article: Inhibition of Adult Neurogenesis in Male Mice after Repeated Exposure to Paracetamol Overdose
Inhibition of Adult Neurogenesis in Male Mice after Repeated Exposure to Paracetamol Overdose Open
Paracetamol or acetaminophen (N-acetyl-para-aminophenol, APAP) is an analgesic and antipy-retic drug commonly used worldwide, implicated in numerous intoxications due to overdose, and causing serious liver damage. APAP can cross the blood-…
View article: The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer’s Disease-like Pathogenesis
The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer’s Disease-like Pathogenesis Open
This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and 5xFAD Tg mouse models that represent earlier or later dise…
View article: Vulnerability of the Critically Endangered leatherback turtle to fisheries bycatch in the eastern Pacific Ocean. I. A machine-learning species distribution model
Vulnerability of the Critically Endangered leatherback turtle to fisheries bycatch in the eastern Pacific Ocean. I. A machine-learning species distribution model Open
The Eastern Pacific population of leatherback turtles Dermochelys coriacea is Critically Endangered, with incidental capture in coastal and pelagic fisheries as one of the major causes. Given the population’s broad geographic range, status…
View article: Antidepressant Medication Does Not Contribute to the Elevated Circulating Concentrations of Acylethanolamides Found in Substance Use Disorder Patients
Antidepressant Medication Does Not Contribute to the Elevated Circulating Concentrations of Acylethanolamides Found in Substance Use Disorder Patients Open
Circulating acylethanolamides (NAEs) are bioactive signaling molecules that modulate multiple homeostatic functions including mood and hedonic responses. Variations in their plasma concentrations are associated with substance use disorders…
View article: Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice Open
View article: Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer’s Disease: Implications for Controlling Astroglial Activity
Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer’s Disease: Implications for Controlling Astroglial Activity Open
Alzheimer’s disease (AD) is a common neurodegenerative disease. In AD-associated neuroinflammation, astrocytes play a key role, finding glial activation both in patients and in animal models. The endocannabinoid system (ECS) is a neurolipi…
View article: Bioética y Legislación Aplicada en Ciencias de la Salud
Bioética y Legislación Aplicada en Ciencias de la Salud Open
El presente manual titulado Bioética y Legislación Aplicada en Ciencias de la Salud ha sido realizado en base al material docente que se imparte al alumnado de la Facultad de Ciencias de la Salud (Grados de Enfermería, Podología y Terapia …
View article: Antipsychotic Medication Influences the Discriminative Value of Acylethanolamides as Biomarkers of Substance Use Disorder
Antipsychotic Medication Influences the Discriminative Value of Acylethanolamides as Biomarkers of Substance Use Disorder Open
Plasma acylethanolamides (NAEs), including the endocannabinoid anandamide (AEA), have been proposed as circulating biomarkers of substance use disorders. However, the concentration of these lipid transmitters might be influenced by the use…
View article: PPARα/CB1 Receptor Dual Ligands as a Novel Therapy for Alcohol Use Disorder: Evaluation in Preclinical Rat Models
PPARα/CB1 Receptor Dual Ligands as a Novel Therapy for Alcohol Use Disorder: Evaluation in Preclinical Rat Models Open
View article: Altered kynurenine pathway in abstinent patients diagnosed with alcohol use disorders and psychiatric comorbidity
Altered kynurenine pathway in abstinent patients diagnosed with alcohol use disorders and psychiatric comorbidity Open
View article: Role for BDNF and Oleoylethanolamide (OEA) in cognitive impairment associated with alcohol use disorders in humans and preclinical models
Role for BDNF and Oleoylethanolamide (OEA) in cognitive impairment associated with alcohol use disorders in humans and preclinical models Open
View article: Acute stress and alcohol exposure during adolescence result in an altered expression of signaling systems associated with emotional behaviors and an adult anxious phenotype
Acute stress and alcohol exposure during adolescence result in an altered expression of signaling systems associated with emotional behaviors and an adult anxious phenotype Open
View article: Partners in Postmortem Interval Estimation: X-ray Diffraction and Fourier Transform Spectroscopy
Partners in Postmortem Interval Estimation: X-ray Diffraction and Fourier Transform Spectroscopy Open
The postmortem interval (PMI) is difficult to estimate in later stages of decomposition. There is therefore a need to develop reliable methodologies to estimate late PMI. This study aims to assess whether there is a correlation between cha…
View article: Sex-based differences in IGF1 signaling pathways in response to PAPP-A2 deficiency
Sex-based differences in IGF1 signaling pathways in response to PAPP-A2 deficiency Open
Background. Patients with pregnancy-associated plasma protein-A2 (PAPP-A2) mutations have progressive postnatal growth retardation and high circulating levels of IGF1 bound in ternary complexes. The present study aims to assess whether Pap…
View article: Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder Open
For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced neurocognitive disorde…