Juan David Ramírez
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View article: Response and therapeutic failure to meglumine antimoniate, the first-line drug for cutaneous leishmaniasis infections in Colombian soldiers
Response and therapeutic failure to meglumine antimoniate, the first-line drug for cutaneous leishmaniasis infections in Colombian soldiers Open
Leishmaniasis is a vector-borne disease caused by Leishmania protozoa, transmitted through infected female phlebotomine sandflies. Cutaneous leishmaniasis (CL), its most common form, causes considerable morbidity, particularly among Colomb…
View article: Outbreak of caterpillars (Lepidoptera) in Valle de Caracas, Venezuela
Outbreak of caterpillars (Lepidoptera) in Valle de Caracas, Venezuela Open
Lepidopterism, a condition resulting from accidents by caterpillars or the adult forms of moths and butterflies, typically manifests as mild and self-limited hypersensitivity reactions. In August 2023, an unexpected number of accidents by …
View article: Dual transcriptomics suggests trophoblastic sequestration and splicing blockade induced by <i>Trypanosoma cruzi</i> during <i>in vitro</i> infection
Dual transcriptomics suggests trophoblastic sequestration and splicing blockade induced by <i>Trypanosoma cruzi</i> during <i>in vitro</i> infection Open
Congenital transmission of Trypanosoma cruzi is a significant public health concern, involving complex interactions between the parasite, the placenta, and the fetus. However, the mechanisms facilitating parasite passage across the placent…
View article: Classification of Inaccurate Information About Prostate Cancer on Social Media in English and Spanish
Classification of Inaccurate Information About Prostate Cancer on Social Media in English and Spanish Open
Inaccurate information about prostate cancer is widespread on online social networks in English and Spanish and spans a variety of topics from prevention and screening to treatment and survivorship. Clinicians should raise awareness that s…
View article: Exploring bacterial and eukaryotic communities in the gut microbiota of urban and rural cats (Felis catus) in Colombia
Exploring bacterial and eukaryotic communities in the gut microbiota of urban and rural cats (Felis catus) in Colombia Open
Cats are essential companions to humans, offering emotional support while potentially harboring infectious agents. Understanding the gut microbiota of domestic cats ( Felis catus ) is critical for advancing feline health and examining envi…
View article: A mathematical model of vaccine hesitancy: Analysing the impact of political trends and the interaction across age and education groups in the USA
A mathematical model of vaccine hesitancy: Analysing the impact of political trends and the interaction across age and education groups in the USA Open
Vaccination against the SARS-CoV-2 disease has significantly reduced its mortality rate and spread. However, despite its availability, a considerable proportion of the public has either refused or delayed getting vaccinated. This reluctanc…
View article: Expedited diagnosis of disseminated <i>Mycobacterium kansasii</i> infection using targeted (amplicon-based) next-generation sequencing in an immunocompromised patient
Expedited diagnosis of disseminated <i>Mycobacterium kansasii</i> infection using targeted (amplicon-based) next-generation sequencing in an immunocompromised patient Open
Background Mycobacterium kansasii is typically associated with pulmonary disease and is an uncommon cause of disseminated infection and thus can be challenging to diagnose and treat. Case Summary We present a 59-year-old female with a hist…
View article: Genomic Characterization of a Locally Transmitted <i>Leishmania mexicana</i> Isolate from Texas
Genomic Characterization of a Locally Transmitted <i>Leishmania mexicana</i> Isolate from Texas Open
Cutaneous leishmaniasis (CL) is caused by Leishmania species transmitted by sand flies. Although considered a neglected tropical disease, growing evidence indicates that local transmission can occur in subtropical, higher-resource regions …
View article: SpikeID: Rapid and unbiased identification of SARS-CoV-2 variants by spike sequencing
SpikeID: Rapid and unbiased identification of SARS-CoV-2 variants by spike sequencing Open
We demonstrate the utility and scalability of the SpikeID assay during the emergence and subsequent surge of Omicron and Omicron-derived lineages in New York City, and show that our approach enables cost-effective, reliable, and near-real-…
View article: Molecular Characterization of <i>Echinococcus vogeli</i> from Human Case, Colombia, 2024
Molecular Characterization of <i>Echinococcus vogeli</i> from Human Case, Colombia, 2024 Open
In Colombia, 35 confirmed cases of neotropical polycystic echinococcosis were reported during 1978-2018. In most cases, Echinococcus vogeli was identified by means of morphologic identification. We describe a case of E. vogeli echinococcos…
View article: Multilocus analysis uncovers the evolution of the Rhodniini tribe, vectors of Trypanosoma cruzi
Multilocus analysis uncovers the evolution of the Rhodniini tribe, vectors of Trypanosoma cruzi Open
In this study, we investigate the origin and diversification of Trypanosoma cruzi vectors within the Rhodniini tribe (Triatominae subfamily) through phylogenetic analyses based on eight genes from 17 species and 497 specimens—the largest s…
View article: Impact of Blastocystis carriage and colonization intensity on gut microbiota composition in a non-westernized rural population from Colombia
Impact of Blastocystis carriage and colonization intensity on gut microbiota composition in a non-westernized rural population from Colombia Open
Background The role of Blastocystis , a common intestinal parasitic protist of humans and other animals, in human health and disease remains elusive. Recent studies suggest a connection between Blastocystis colonization, healthier lifestyl…
View article: Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems
Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems Open
The gut microbiome plays a critical role in modulating host metabolism, influencing energy production, nutrient utilization, and overall physiological adaptation. In athletes, these microbial functions may be further specialized to meet th…
View article: Heart rate variability derangements in dogs with Chagas disease: a potential indicator of autonomic and cardiac disruption
Heart rate variability derangements in dogs with Chagas disease: a potential indicator of autonomic and cardiac disruption Open
Objective To assess heart rate variability (HRV) as a marker of autonomic nervous system disruption and its role in disease progression in dogs with Chagas disease (CD), and to evaluate arrhythmias and conduction abnormalities in symptomat…
View article: Unveiling shifts in cervical microbiota composition among Colombian women in the presence of Trichomonas vaginalis: a longitudinal study
Unveiling shifts in cervical microbiota composition among Colombian women in the presence of Trichomonas vaginalis: a longitudinal study Open
Trichomonas vaginalis is a flagellated protozoan affecting human reproductive health. Although bacterial coinfections have been associated with T. vaginalis infection outcomes, pertinent data are scarce. This study was aimed at assessing v…
View article: Metagenomic Analysis of Surface Waters and Wastewater in the Colombian Andean Highlands: Implications for Health and Disease
Metagenomic Analysis of Surface Waters and Wastewater in the Colombian Andean Highlands: Implications for Health and Disease Open
Urban water bodies serve as critical reservoirs of microbial diversity, with major implications for public health and environmental quality. This study aimed to characterize the microbial diversity of surface waters and wastewater from the…
View article: The genome sequence of the kissing bug, Panstrongylus geniculatus (Latreille, 1811)
The genome sequence of the kissing bug, Panstrongylus geniculatus (Latreille, 1811) Open
We present a genome assembly from an individual female Panstrongylus geniculatus (kissing bug; Arthropoda; Insecta; Hemiptera; Reduviidae). The assembly contains two haplotypes with total lengths of 1,362.73 megabases and 1,342.40 megabase…
View article: Triatoma venosa and Panstrongylus geniculatus challenge the certification of interruption of vectorial Trypanosoma cruzi transmission by Rhodnius prolixus in eastern Colombia
Triatoma venosa and Panstrongylus geniculatus challenge the certification of interruption of vectorial Trypanosoma cruzi transmission by Rhodnius prolixus in eastern Colombia Open
Reactivation of Trypanosoma cruzi transmission by native vectors with different domiciliation capabilities is a major concern for Chagas disease control programs . T. cruzi transmission via intra-domestic Rhodnius prolixus was certified as…
View article: First evidence of human infection by the kinetoplastid flagellate Dimastigella trypaniformis in a patient with urinary tract infection
First evidence of human infection by the kinetoplastid flagellate Dimastigella trypaniformis in a patient with urinary tract infection Open
The identification of D. trypaniformis in a clinical specimen expands the spectrum of potential urinary pathogens and raises questions about its clinical significance and pathogenic potential. This report underscores the need for heightene…
View article: Understanding Host–Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches
Understanding Host–Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches Open
Chagas disease, caused by Trypanosoma cruzi, is a parasitic zoonosis with significant health impacts, particularly in Latin America. While traditionally associated with vector-borne transmission, increased migration has expanded its reach …
View article: Fatal Mixed <i>Plasmodium</i> Infection in Traveler Returning to Colombia from Comoros Islands, 2024
Fatal Mixed <i>Plasmodium</i> Infection in Traveler Returning to Colombia from Comoros Islands, 2024 Open
During 2014-2022, only Plasmodium falciparum malaria cases were reported in the Comoro Islands. We report a fatal case of mixed Plasmodium malaria infection in a traveler returning from the Comoros to Colombia in 2024, highlighting the nee…