Juanjie Tang
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View article: SARS-CoV-2 mRNA vaccination elicits distinct pharyngeal mucosal B cell responses in children compared to infection 3915
SARS-CoV-2 mRNA vaccination elicits distinct pharyngeal mucosal B cell responses in children compared to infection 3915 Open
Description Tonsils and adenoids are mucosal lymphoid tissues in the upper airway with unique lymphocytes not found in blood. We recently reported that SARS-CoV-2 infection elicits robust, enduring adaptive immune responses in these tissue…
View article: SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children
SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children Open
View article: Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C Open
View article: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C Open
View article: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates
Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates Open
Immunization with mRNA or viral vectors encoding spike with diproline substitutions (S-2P) has provided protective immunity against severe COVID-19 disease. How immunization with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
View article: 2368. SARS-CoV-2 mRNA vaccination induces B cell immunity in the tonsils and adenoids of children
2368. SARS-CoV-2 mRNA vaccination induces B cell immunity in the tonsils and adenoids of children Open
Background We recently reported that SARS-CoV-2 infection triggered robust adaptive immune responses in the tonsils and adenoids of children. However, whether intramuscular mRNA vaccination induces immunity in these tissues is unknown. Met…
View article: mRNA vaccination induces persistent pharyngeal mucosal B cell responses to SARS-CoV-2 in children
mRNA vaccination induces persistent pharyngeal mucosal B cell responses to SARS-CoV-2 in children Open
We recently reported that SARS-CoV-2 infection triggers robust, persistent adaptive immune responses in the tonsils and adenoids of children. However, whether mRNA vaccination induces similar immune responses and how this compares to natur…
View article: Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Open
Acute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly understood. Here we use systems immunolo…
View article: Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Open
View article: Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Open
Acute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly understood. Here we use systems immunolo…
View article: Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children Open
View article: Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine Open
View article: Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C Open
View article: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C Open
View article: D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes Open
An overreactive inflammatory response and coagulopathy are observed in patients with severe form of COVID-19. Since increased levels of D-dimer (DD) are associated with coagulopathy in COVID-19, we explored whether DD contributes to the ab…
View article: Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C
Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C Open
Mucosal immunity plays an important role in the control of viral respiratory infections like SARS-CoV-2. While systemic immune responses against the SARS-2-CoV-2 have been studied in children, there is no information on mucosal antibody re…
View article: Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children
Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children Open
View article: SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women
SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women Open
View article: Influenza vaccination and single cell multiomics reveal sex dimorphic immune imprints of prior mild COVID-19
Influenza vaccination and single cell multiomics reveal sex dimorphic immune imprints of prior mild COVID-19 Open
Viral infections can have profound and durable functional impacts on the immune system. There is an urgent need to characterize the long-term immune effects of SARS-CoV-2 infection given the persistence of symptoms in some individuals and …
View article: Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C
Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-C Open
Mucosal immunity plays an important role in the control of viral respiratory infections like SARS-CoV-2. While systemic immune responses against the SARS-2-CoV-2 have been studied in children, there is no information on mucosal antibody re…
View article: Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine Open
Coronavirus vaccines that are highly effective against SARS-CoV-2 variants are needed to control the current pandemic. We previously reported a receptor-binding domain (RBD) sortase A-conjugated ferritin nanoparticle (RBD-scNP) vaccine tha…
View article: Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019
Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019 Open
Passive antibody immunotherapeutics directed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are promising countermeasures for protection and treatment of coronavirus disease 2019 (COVID-19). SARS-CoV-2 variants of con…
View article: Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine Open
View article: A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice Open
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality associated with sarbecovirus infection underscores the importance of deve…
View article: Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sex
Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sex Open
View article: Protective antigenic sites identified in respiratory syncytial virus fusion protein reveals importance of p27 domain
Protective antigenic sites identified in respiratory syncytial virus fusion protein reveals importance of p27 domain Open
View article: A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice Open
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality associated with sarbecovirus infection underscores the importance of deve…
View article: Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2–infected individuals reveal unlinked immune signatures
Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2–infected individuals reveal unlinked immune signatures Open
Mucosal SARS-CoV-2 immune profiles are divergent in asymptomatic versus symptomatic SARS-CoV-2–infected individuals.
View article: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19 Open
View article: Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern
Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern Open