Juanjuan Luo
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View article: Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade
Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade Open
Glioma stem cells (GSCs) are a primary factor contributing to the failure of glioma treatment and lead to a poor prognosis for patients with glioma. However, the biological functions and mechanisms involved in regulating stemness maintenan…
View article: A novel Synthesis of fluorescent nanoprobe for high-efficiency detection of Cu<sup>2+</sup> in water
A novel Synthesis of fluorescent nanoprobe for high-efficiency detection of Cu<sup>2+</sup> in water Open
This paper mainly studies the preparation of nitrogen-doped carbon nanoparticles (N-CNPs), which are used as fluorescent probes for the detection of copper ions (Cu 2+ ) in actual environmental water samples. The novel synthesis method is …
View article: Enhancement of Fracture Toughness of Inner Liner Material for Type IV Hydrogen Storage Cylinders Based on Molecular Dynamics Method
Enhancement of Fracture Toughness of Inner Liner Material for Type IV Hydrogen Storage Cylinders Based on Molecular Dynamics Method Open
To develop liner materials with improved toughness, this study combines molecular dynamics simulations and experimental testing to investigate the effect of different mass ratios (10/0, 7/3, 6/4, 4/6, 3/7, and 0/10) of high-density polyeth…
View article: Coacervates of Lactoferrin with Resistant Dextrin via Noncovalent Interaction for Enhanced Thermal Stability, Interface Characteristics and Docosahexaenoic Acid (DHA) Encapsulation
Coacervates of Lactoferrin with Resistant Dextrin via Noncovalent Interaction for Enhanced Thermal Stability, Interface Characteristics and Docosahexaenoic Acid (DHA) Encapsulation Open
View article: Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio)
Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio) Open
The results of this study suggest that NPs induce oxidative stress in vascular ECs and HSPCs, which mediates CVP damage and impairs hematopoiesis in zebrafish embryos.
View article: Silver Nanoparticles Exposure Impairs Cardiac Development by Suppressing the Focal Adhesion Pathway in Zebrafish
Silver Nanoparticles Exposure Impairs Cardiac Development by Suppressing the Focal Adhesion Pathway in Zebrafish Open
Thus, our findings illustrated that AgNPs could impair cardiac development by regulating the focal adhesion pathway in zebrafish.
View article: Effect of thermal and nonthermal processing methods on the structural and functional properties of whey protein from donkey milk
Effect of thermal and nonthermal processing methods on the structural and functional properties of whey protein from donkey milk Open
This study evaluated the effect of thermal, ultrasonication, and UV treatment on the structural and functional properties of whey proteins from donkey milk. Whey proteins exhibited notable stability in nonheat-treated environments, but the…
View article: Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio)
Acute indomethacin exposure impairs cardiac development by affecting cardiac muscle contraction and inducing myocardial apoptosis in zebrafish (Danio rerio) Open
The accumulation of the active pharmaceutical chemical in the environment usually results in environmental pollution to increase the risk to human health. Indomethacin is a non-steroidal anti-inflammatory drug that potentially causes syste…
View article: The potential toxic effects of estrogen exposure on neural and vascular development in zebrafish
The potential toxic effects of estrogen exposure on neural and vascular development in zebrafish Open
Estrogens and estrogenic chemicals are endocrine-disrupting chemicals (EDCs). The potential toxicity of EDCs to humans and aquatic organisms has become increasingly concerning. However, at present, the potential toxic mechanisms of EDCs on…
View article: Protocol for tissue-specific mutagenesis with fluorescent labeling in zebrafish
Protocol for tissue-specific mutagenesis with fluorescent labeling in zebrafish Open
Here, we present a protocol for tissue-specific mutagenesis in zebrafish. We describe the preparation of the Tol2 transposase donor vector containing a U6 promoter that drives the transcription of single-guide RNAs (sgRNAs) and Cas9 under …
View article: Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population
Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population Open
View article: Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells
Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells Open
Roxithromycin (ROX), a commonly used macrolide antibiotic, is extensively employed in human medicine and livestock industries. Due to its structural stability and resistance to biological degradation, ROX persists as a resilient environmen…
View article: Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (<i>Danio rerio</i>)
Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (<i>Danio rerio</i>) Open
The global accumulation and adverse effects of nanoplastics (NPs) are a growing concern for the environment and human health. In recent years, more and more studies have begun to focus on the toxicity of plastic particles for early animal …
View article: Docosahexaenoic acid–mediated milk protein treated by ultrasound-assisted pH shifting for enhanced astaxanthin delivery and processed cheese application
Docosahexaenoic acid–mediated milk protein treated by ultrasound-assisted pH shifting for enhanced astaxanthin delivery and processed cheese application Open
Whey protein isolate (WPI)-based nanodelivery systems have recently attracted an increasing amount of attention. Despite this, research focusing on milk protein concentrate (MPC) and micellar casein (MCC) as carriers loaded in hydrophobic …
View article: Machine Learning-Aided Quantitative Detection of Two Mixed Antibiotics in a Narrow Concentration Range Based on Oxygen Incorporation-Induced 3d Sers Substrates
Machine Learning-Aided Quantitative Detection of Two Mixed Antibiotics in a Narrow Concentration Range Based on Oxygen Incorporation-Induced 3d Sers Substrates Open
View article: Protocol for generating mutant zebrafish using CRISPR-Cas9 followed by quantitative evaluation of vascular formation
Protocol for generating mutant zebrafish using CRISPR-Cas9 followed by quantitative evaluation of vascular formation Open
View article: Silver Nanoparticles Cause Neural and Vascular Disruption by Affecting Key Neuroactive Ligand-Receptor Interaction and VEGF Signaling Pathways
Silver Nanoparticles Cause Neural and Vascular Disruption by Affecting Key Neuroactive Ligand-Receptor Interaction and VEGF Signaling Pathways Open
Our findings indicate that AgNP exposure transcriptionally induces developmental toxicity in neural and vascular development by disturbing neuroactive ligand-receptor interactions and the Vegf signaling pathway in zebrafish embryos.
View article: Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis Open
Cyclic GMP-AMP synthase (cGAS) senses cytosolic incoming DNA and consequently activates stimulator of interferon response cGAMP interactor 1 (STING) to mount immune response. Here, we show nuclear cGAS could regulate VEGF-A-mediated angiog…
View article: <scp>L1CAM</scp> promotes vasculogenic mimicry formation by <scp>miR</scp>‐143‐3p‐induced expression of hexokinase 2 in glioma
<span>L1CAM</span> promotes vasculogenic mimicry formation by <span>miR</span>‐143‐3p‐induced expression of hexokinase 2 in glioma Open
In recent decades, antiangiogenic therapy, which blocks the supply of oxygen and nutrition to tumor cells, has become a promising clinical strategy for the treatment of patients with tumors. However, recent studies revealed that vasculogen…
View article: Hepatoprotective Effects of High Fischer's Ratio Oligopeptides from Goat Whey Against CCL<sub>4</sub>-Induced Acute Liver Injury&nbsp;In Mice
Hepatoprotective Effects of High Fischer's Ratio Oligopeptides from Goat Whey Against CCL<sub>4</sub>-Induced Acute Liver Injury In Mice Open
View article: Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (<i>Danio rerio</i>)
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (<i>Danio rerio</i>) Open
The widespread accumulation of nanoplastics is a growing concern for the environmental and human health. However, studies on the mechanisms of nanoplastic-induced developmental toxicity are still limited. Here, we systematically investigat…
View article: Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio)
Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio) Open
View article: Current understanding of gliomagenesis: from model to mechanism
Current understanding of gliomagenesis: from model to mechanism Open
Glioma, a kind of central nervous system (CNS) tumor, is hard to cure and accounts for 32% of all CNS tumors. Establishing a stable glioma model is critically important to investigate the underlying molecular mechanisms involved in tumorig…
View article: Tunable Excited State and its Effect on Photoluminescence and Electroluminescence Process in Tetraphenylpyrazine-Modified Anthracene-Based Derivatives
Tunable Excited State and its Effect on Photoluminescence and Electroluminescence Process in Tetraphenylpyrazine-Modified Anthracene-Based Derivatives Open
View article: Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish
Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish Open
View article: Additional file 1 of Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish
Additional file 1 of Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish Open
Additional file 1: Supplemental Figure 1. Targeted expression of transgenes in zebrafish embryos. a-c T7E1 assays and DNA sequencing were performed to determine the mutations of tp53 (a), ptena (b) and ptenb (c) in whole embryos injected w…
View article: Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish
Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish Open
The molecular pathogenesis of glioblastoma indicates that RTK/Ras/PI3K, RB and TP53 pathways are critical for human gliomagenesis. Here, several transgenic zebrafish lines with single or multiple deletions of nf1, tp53 and rb1 in astrocyte…
View article: The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro
The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro Open
The base excision repair (BER) pathway is an important defense response to oxidative DNA damage. It is known that exposures to phthalate esters (PAEs), including Dibutyl phthalate (DBP), Mono-(2-ethylhexyl) phthalate (MEHP), and Di-(2-ethy…
View article: An analytical method for J-resistance curve based on a new fracture criteria and finite element aided testing method
An analytical method for J-resistance curve based on a new fracture criteria and finite element aided testing method Open
J -resistance curve of ductile material is important to describe the ability of a crack structure or material to resist fracture. Experimental and theoretical methods are developed to obtain J -resistance curve of metallic material. Howeve…
View article: AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair
AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair Open