Juanlin Chen
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Unveiling Aging and Alzheimer's Disease–Associated Dynamics of <span>LINE1 DNA</span> Content and Protein Expression in Mouse Brains Open
Despite the long interspersed nuclear element‐1 (LINE1, L1) retrotransposons having been implicated in Alzheimer's disease (AD), a fundamental understanding of the AD‐specific lifespan‐long trajectory of L1 has been limited. Here, we chara…
Unveiling Aging and Alzheimer's Disease–Associated Dynamics of <span>LINE1 DNA</span> Content and Protein Expression in Mouse Brains Open
Despite the long interspersed nuclear element‐1 (LINE1, L1) retrotransposons having been implicated in Alzheimer's disease (AD), a fundamental understanding of the AD‐specific lifespan‐long trajectory of L1 has been limited. Here, we chara…
View article: Telomere length and micronuclei trajectories in <scp>APP</scp>/<scp>PS1</scp> mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner
Telomere length and micronuclei trajectories in <span>APP</span>/<span>PS1</span> mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner Open
Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of genome instability linked to AD pathogenesis remain poorly understood. Here, we report the first cha…