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View article: Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells
Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells Open
Background Osteoarthritis is a degenerative joint disease characterized by progressive loss of articular cartilage and limited capacity for intrinsic repair. A major barrier to developing effective regenerative strategies is the incomplete…
View article: Isolation and Micromass Culturing of Primary Chicken Chondroprogenitor Cells for Cartilage Regeneration
Isolation and Micromass Culturing of Primary Chicken Chondroprogenitor Cells for Cartilage Regeneration Open
Much of the skeletal system develops by endochondral ossification, a process that takes place in early fetal life. This makes the early stages of chondrogenesis, i.e., when chondroprogenitor mesenchymal cells differentiate to chondroblasts…
View article: Combining biomechanical stimulation and chronobiology: a novel approach for augmented chondrogenesis?
Combining biomechanical stimulation and chronobiology: a novel approach for augmented chondrogenesis? Open
The unique structure and composition of articular cartilage is critical for its physiological function. However, this architecture may get disrupted by degeneration or trauma. Due to the low intrinsic regeneration properties of the tissue,…
View article: The temporal transcriptomic signature of cartilage formation
The temporal transcriptomic signature of cartilage formation Open
Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue with distinct structural and functional properties. Although several approaches to cartilage regeneration rely on the differentiation of implanted…
View article: Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock Open
The biomechanical environment plays a key role in regulating cartilage formation, but the current understanding of mechanotransduction pathways in chondrogenic cells is incomplete. Among the combination of external factors that control cho…
View article: The temporal transcriptomic signature of cartilage formation
The temporal transcriptomic signature of cartilage formation Open
Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue with distinct structural and functional properties. Although several approaches to cartilage regeneration rely on the differentiation of implanted…
View article: Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock Open
The biomechanical environment plays a key role in regulating cartilage formation, but current understanding of mechanotransduction pathways in chondrogenic cells is incomplete. Amongst the combination of external factors that control chond…
View article: Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models
Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models Open
We investigated the gene expression pattern of selected enzymes involved in DNA methylation and the effects of the DNA methylation inhibitor 5-azacytidine during in vitro and in vivo cartilage formation. Based on the data of a PCR array pe…
View article: Pituitary Adenylate Cyclase Activating Polypeptide Has Inhibitory Effects on Melanoma Cell Proliferation and Migration In Vitro
Pituitary Adenylate Cyclase Activating Polypeptide Has Inhibitory Effects on Melanoma Cell Proliferation and Migration In Vitro Open
Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide which is distributed throughout the body. PACAP influences development of various tissues and exerts protective function during cellular stress and in…
View article: Modulation of DNA Methylation Influences Cartilage Formation in Murine Chondrogenic Models
Modulation of DNA Methylation Influences Cartilage Formation in Murine Chondrogenic Models Open
The aim of this study was to investigate the role of DNA methylation in the regulation of in vitro and in vivo cartilage formation. Based on the data of an RNA chip-assay performed on chondrifying BMP2-overexpressing C3H10T1/2 cells, the r…
View article: A Synchronized Circadian Clock Enhances Early Chondrogenesis
A Synchronized Circadian Clock Enhances Early Chondrogenesis Open
Objective Circadian rhythms in cartilage homeostasis are hypothesized to temporally segregate and synchronize the activities of chondrocytes to different times of the day, and thus may provide an efficient mechanism by which articular cart…
View article: Age-related alterations of articular cartilage in pituitary adenylate cyclase–activating polypeptide (PACAP) gene–deficient mice
Age-related alterations of articular cartilage in pituitary adenylate cyclase–activating polypeptide (PACAP) gene–deficient mice Open
Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionarly conserved neuropeptide which is produced by various neuronal and non-neuronal cells, including cartilage and bone cells. PACAP has trophic functions in tissue d…