Judit Zsuga
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View article: The interaction of AB-680, a CD73 inhibitor, with NBTI, a nucleoside transporter inhibitor, on the adenosinergic control of atrial contractility
The interaction of AB-680, a CD73 inhibitor, with NBTI, a nucleoside transporter inhibitor, on the adenosinergic control of atrial contractility Open
Introduction In this study, we investigated the influence of AB-680, a highly potent CD73 inhibitor, on the effect of NBTI, a nucleoside transport blocker, exerted on concentration-effect (E/c) curves generated with CPA, a relatively stabl…
View article: Reward boosts cognitive control during working memory maintenance
Reward boosts cognitive control during working memory maintenance Open
Working memory (WM) involves short-term maintenance and manipulation of goal-relevant information, with cognitive control playing a crucial role in these processes due to WM’s limited capacity. Pupillometry studies show distinct pupillary …
View article: The flexibility of SABRE, a new quantitative receptor function model, when fitting challenging concentration-effect data
The flexibility of SABRE, a new quantitative receptor function model, when fitting challenging concentration-effect data Open
The Signal Amplification, Binding affinity, and Receptor-activation Efficacy (SABRE) model is the most recent general and quantitative model of receptor function, which enables the determination of K d (the equilibrium dissociation constan…
View article: Operatic voices engage the default mode network in professional opera singers
Operatic voices engage the default mode network in professional opera singers Open
Extensive research with musicians has shown that instrumental musical training can have a profound impact on how acoustic features are processed in the brain. However, less is known about the influence of singing training on neural activit…
View article: Mesocorticolimbic and Cardiometabolic Diseases—Two Faces of the Same Coin?
Mesocorticolimbic and Cardiometabolic Diseases—Two Faces of the Same Coin? Open
The risk behaviors underlying the most prevalent chronic noncommunicable diseases (NCDs) encompass alcohol misuse, unhealthy diets, smoking and sedentary lifestyle behaviors. These are all linked to the altered function of the mesocorticol…
View article: Association of monoaminergic gene polymorphisms in chronic inflammatory pulmonary disease patients with successful smoking cessation
Association of monoaminergic gene polymorphisms in chronic inflammatory pulmonary disease patients with successful smoking cessation Open
View article: Predicting Stroke Risk Based on ICD Codes Using Graph-Based Convolutional Neural Networks
Predicting Stroke Risk Based on ICD Codes Using Graph-Based Convolutional Neural Networks Open
In recent years, convolutional neural networks (CNNs) have emerged as highly efficient architectures for image and audio classification tasks, gaining widespread adoption in state-of-the-art methodologies. While CNNs excel in machine learn…
View article: The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor
The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor Open
The receptorial responsiveness method (RRM) enables the estimation of a change in concentration of an (even degradable) agonist, near its receptor, via curve fitting to (at least) two concentration-effect (E/c) curves of a stable agonist. …
View article: The ex vivo effects of hypoxanthine-tricyclano, a synthetic adenosine analogue, on rat left and right atria
The ex vivo effects of hypoxanthine-tricyclano, a synthetic adenosine analogue, on rat left and right atria Open
Hypoxanthine-tricyclano is a synthetic adenosine analogue, in which adenine and ribose have been replaced by hypoxanthine and a morpholino-derived tricyclic moiety, respectively. We investigated whether hypoxanthine-tricyclano could influe…
View article: Experience-Dependent Neural Responses to Vocal Vibrato in Opera Singers
Experience-Dependent Neural Responses to Vocal Vibrato in Opera Singers Open
Extensive research with musicians has shown that instrumental musical training can have a profound impact on how acoustic features are processed in the brain. However, less is known about the influence of singing training on neural activit…
View article: The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor
The influence of the way of regression on the results obtained by the receptorial responsiveness method (RRM), a procedure to estimate a change in the concentration of a pharmacological agonist near the receptor Open
The receptorial responsiveness method (RRM) enables the estimation of a change in the concentration of a degradable agonist, near its receptor, by fitting its model to (at least) two concentration-effect (E/c) curves of a stable agonist of…
View article: The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium
The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium Open
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim of this study was to explore the effect that CBD exerts on…
View article: A bábterápia és a sématerápia szinergizmusainak ötvözése a pszichoterápiás munkában
A bábterápia és a sématerápia szinergizmusainak ötvözése a pszichoterápiás munkában Open
A bábterápia a bábjáték nevelő célzatú hatásaira, a bábjátékkal való fejlesztésre épül, és egyedi eszközei révén fejti ki terápiás hatásait. A sématerápia az 1990-es években megjelent, pszichoterápiás irányzat, ami a pszichiátriai zavarok …
View article: Prebiotikum tartalmú kapszulák formulálása és vizsgálata
Prebiotikum tartalmú kapszulák formulálása és vizsgálata Open
A prebiotikumok a szervezet számára nem emészthető élelmiszer-összetevők, melyek változatlan formában eljutnak a vastagbélbe, ahol a szervezet számára hasznos baktériumtörzsek számára tápanyagként szolgálnak és segítik a szaporodásukat. Je…
View article: An Exploratory Assessment of Factors with Which Influenza Vaccine Uptake Is Associated in Hungarian Adults 65 Years Old and Older: Findings from European Health Interview Surveys
An Exploratory Assessment of Factors with Which Influenza Vaccine Uptake Is Associated in Hungarian Adults 65 Years Old and Older: Findings from European Health Interview Surveys Open
Influenza vaccination is an imperative public health task for elderly people due to a higher risk of developing more severe complications. The main aim of our study was to determine the influencing factors of being vaccinated against influ…
View article: Awareness Related to Cardiometabolic Diseases: A Cross-Sectional Study in Southern Vietnam
Awareness Related to Cardiometabolic Diseases: A Cross-Sectional Study in Southern Vietnam Open
Background: the prevalence of cardiometabolic diseases (CMDs), such as type 2 diabetes mellitus (T2DM) and hypertension, is increasing rapidly in developing countries. This study aims to assess the awareness of CMD among a selected populat…
View article: A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far
A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far Open
In previous studies using isolated, paced guinea pig left atria, we observed that FSCPX, known as a selective A1 adenosine receptor antagonist, paradoxically increased the direct negative inotropic response to A1 adenosine receptor agonist…
View article: Vestibular Stimulation May Drive Multisensory Processing: Principles for Targeted Sensorimotor Therapy (TSMT)
Vestibular Stimulation May Drive Multisensory Processing: Principles for Targeted Sensorimotor Therapy (TSMT) Open
At birth, the vestibular system is fully mature, whilst higher order sensory processing is yet to develop in the full-term neonate. The current paper lays out a theoretical framework to account for the role vestibular stimulation may have …
View article: Association between Oral Hygiene and Metabolic Syndrome: A Systematic Review and Meta-Analysis
Association between Oral Hygiene and Metabolic Syndrome: A Systematic Review and Meta-Analysis Open
Emerging evidence has linked poor oral hygiene to metabolic syndrome (MetS), but previously, no summary of evidence has been conducted on the topic. This systematic review and meta-analysis aims to evaluate the associations of oral hygiene…
View article: Predicting the epidemic curve of the coronavirus (SARS-CoV-2) disease (COVID-19) using artificial intelligence: An application on the first and second waves
Predicting the epidemic curve of the coronavirus (SARS-CoV-2) disease (COVID-19) using artificial intelligence: An application on the first and second waves Open
View article: Acute stroke awareness of family physicians: translation of policy to practice
Acute stroke awareness of family physicians: translation of policy to practice Open
View article: Socioeconomic Factors Predicting Depression Differ in the Acute Stage and at 1 year After Ischemic Stroke or TIA
Socioeconomic Factors Predicting Depression Differ in the Acute Stage and at 1 year After Ischemic Stroke or TIA Open
Predictors of the severity of depressive symptoms differed in the acute phase and at follow-up. In addition to disability, education and employment status in the acute phase and income in the late phase predict the severity of depressive s…
View article: Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis
Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis Open
The results suggest that all IIM patients have thinner corneas compared with those of controls, and decreased corneal parameters are significantly associated with the occurrence of some extramuscular manifestations. In addition, IIM patien…
View article: Negative Inotropic Effect of BGP-15 on the Human Right Atrial Myocardium
Negative Inotropic Effect of BGP-15 on the Human Right Atrial Myocardium Open
Cardiovascular morbidity and mortality carry great socioeconomic burden worldwide that mandates the development of new, efficacious therapeutic agents with limited adverse effects. O-(3-piperidino-2-hydroxy-1-propyl) nicotinic acid amidoxi…
View article: Predicting the Epidemic Curve of the Coronavirus (SARS-CoV-2) Disease (COVID-19) Using Artificial Intelligence
Predicting the Epidemic Curve of the Coronavirus (SARS-CoV-2) Disease (COVID-19) Using Artificial Intelligence Open
The aim of our study was to predict the epidemic curves (daily new cases) of COVID-19 pandemic using Artificial Intelligence (AI)-based Recurrent Neural Networks (RNNs), then to compare and validate the predicted models with the observed d…
View article: Vestibular stimulation and primitive reflex integration may drive multisensory processing: putative principles for a Targeted sensorimotor therapy (TSMT)
Vestibular stimulation and primitive reflex integration may drive multisensory processing: putative principles for a Targeted sensorimotor therapy (TSMT) Open
Background: At birth the vestibular system is fully mature, and primitive reflexes are functional whilst higher order sensory processing is yet to develop in the full-term neonate. Sequential motor development driven by primitive survival …
View article: Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists
Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists Open
The receptorial responsiveness method (RRM) is a procedure that is based on a simple nonlinear regression while using a model with two variables (X, Y) and (at least) one parameter to be determined (cx). The model of RRM describes the co-a…
View article: Corneal Manifestations of Inflammatory Bowel Disease
Corneal Manifestations of Inflammatory Bowel Disease Open
Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn's disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and other…
View article: Notification Strategy and Predictors of Outcome in Stroke Ineligible for Reperfusion Therapies
Notification Strategy and Predictors of Outcome in Stroke Ineligible for Reperfusion Therapies Open
Background, Objective: At least 70% of all stroke patients are ineligible for recanalization therapy. We identified predictors of outcome among these patients, with special focus on notification of emergency medical services (EMS). …
View article: A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis
A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis Open
Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc.Methods: …