Judith Brands
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View article: Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery
Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery Open
BACKGROUND: Hypertensive disorders of pregnancy (HDP) are associated with subsequent adverse cardiac remodeling and cardiovascular disease. The role of myocardial microvascular disease among individuals with HDP and left ventricular (LV) r…
View article: Antiviral CD8<sup>+</sup>T-cell immune responses are impaired by cigarette smoke and in COPD
Antiviral CD8<sup>+</sup>T-cell immune responses are impaired by cigarette smoke and in COPD Open
Background Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 + T-cells by viral epitopes presented on major histocompatibility complex (MHC) class I molecules of i…
View article: CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling
CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling Open
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5…
View article: Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum
Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum Open
Preeclampsia is a spontaneously occurring, pregnancy-specific syndrome that is clinically diagnosed by new onset hypertension and proteinuria. Epidemiological evidence describes an association between a history of preeclampsia and increase…
View article: Noninvasive sublingual microvascular imaging reveals sex‐specific reduction in glycocalyx barrier properties in patients with coronary artery disease
Noninvasive sublingual microvascular imaging reveals sex‐specific reduction in glycocalyx barrier properties in patients with coronary artery disease Open
Our data suggest that patients with CAD are characterized by a reduction in percentage of time microvessels are occupied by RBCs. In addition, CAD is significantly associated with impaired sublingual microvascular glycocalyx barrier functi…
View article: <scp>ATF</scp>3 represses <scp>PINK</scp>1 gene transcription in lung epithelial cells to control mitochondrial homeostasis
<span>ATF</span>3 represses <span>PINK</span>1 gene transcription in lung epithelial cells to control mitochondrial homeostasis Open
Summary PINK 1 ( PTEN ‐induced putative kinase 1) is a key regulator of mitochondrial homeostasis that is relatively depleted in aging lungs and in lung epithelial cells from patients with idiopathic pulmonary fibrosis ( IPF ), a disease l…
View article: P101 <break /> Fibrosis as a Disease of Aging and Mitochondrial Dysfunction
P101 Fibrosis as a Disease of Aging and Mitochondrial Dysfunction Open
Despite the fact that Idiopathic Pulmonary Fibrosis (IPF) is a fatal and progressive lung disease of unknown etiology whose prevalence dramatically increases with age, few new pathobiologic models have emerged. Repetitive injury of mitocho…