Judith E. Unterlass
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View article: Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis
Kinetic and structural characterization of <span>NUDT15</span> and <span>NUDT18</span> as catalysts of isoprene pyrophosphate hydrolysis Open
Isoprene pyrophosphates play a crucial role in the synthesis of a diverse array of essential nonsterol and sterol biomolecules and serve as substrates for posttranslational isoprenylation of proteins, enabling specific anchoring to cellula…
View article: Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis
Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis Open
Isoprene pyrophosphates play a crucial role in the synthesis of a diverse array of essential nonsterol and sterol biomolecules, and serve as substrates for post-translational isoprenylation of proteins, enabling specific anchoring to cellu…
View article: CCDC 2303246: Experimental Crystal Structure Determination
CCDC 2303246: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase Open
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spect…
View article: Supplementary methods for "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress"
Supplementary methods for "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress" Open
Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
View article: Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress Open
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clini…
View article: Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism
Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism Open
Metabolism is highly interconnected and also has profound effects on other cellular processes. However, the interactions between metabolites and proteins that mediate this connectivity are frequently low affinity and difficult to discover,…
View article: Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress Open
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguani…
View article: Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target Open
View article: Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)
Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH) Open
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role o…
View article: A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate Open
We describe the synthesis and biological evaluation of 1-PP-Ins(4,5)P2, the first diphosphate-containing analogue of the intracellular signalling molecule Ins(1,4,5)P3.
View article: A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family Open
View article: Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)
Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH) Open
Cancer cells reprogram their metabolism and energy production to sustain increased growth, enable metastasis and overcome resistance to cancer treatments. Although primary roles for many metabolic proteins have been identified, some are pr…
View article: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer Open
3-Phosphoglycerate dehydrogenase (PHGDH) has recently been identified as an attractive target in cancer therapy as it links upregulated glycolytic flux to increased biomass production in cancer cells. PHGDH catalyses the first step in the …