Judith Farrés
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Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer Open
In silico clinical trials that simulate individualized mechanisms of action offer a powerful approach to assess drug efficacy across large and diverse patient populations, while also enabling the identification of predictive biomarkers. In…
NSAIDS-XDR-TB clinical trial: A randomized pilot study to estimate the potential efficacy and safety of using adjunctive ibuprofen for the treatment of pre-XDR and XDR tuberculosis Open
Background Drug-resistant tuberculosis (TB) remains a formidable global health challenge. Host-directed therapies (HDTs) offer the potential to mitigate tissue damage, reduce treatment duration, and improve clinical outcomes by modulating …
Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project Open
Our findings relate specific molecular alterations of GC tumors from Europe and LATAM to actionable biomarkers for precision cancer therapies. The proposed GC stratification can be implemented in routine care and guide drug development str…
MMPred: a tool to predict peptide mimicry events in MHC class II recognition Open
We present MMPred, a software tool that integrates epitope prediction and sequence alignment algorithms to streamline the computational analysis of molecular mimicry events in autoimmune diseases. Starting with two protein or peptide sets …
Integration of expression datasets to identify biomarkers for accurate Gleason scoring in Prostate Cancer Open
Prostate cancer is a significant global health issue with considerable mortality rates, emphasising the urgent need for advanced treatment options and improved diagnostic methods. Current diagnostic standards for prostate cancer, including…
A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status Open
Oncology treatments require continuous individual adjustment based on the measurement of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical data could be used to assist decision making and ease t…
The usage of transcriptomics datasets as sources of Real-World Data for clinical trialling Open
Background Randomised Clinical Trials (RCT) reflect results within their specific controlled settings, necessitating further studies to understand outcomes across all possible scenarios. The usage of Real-World Data (RWD) has been recently…
View article: The mechanism of macroautophagy: The movie
The mechanism of macroautophagy: The movie Open
This animated movie presents the mechanism of macroautophagy, hereafter autophagy, by showing the molecular features of the formation of autophagosomes, the hallmark organelle of this intracellular catabolic pathway. It is based on our cur…
Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic Open
Design and objectives A cross-sectional study to evaluate the impact of COVID-19 on the psychosocial sphere in both the general population and healthcare workers (HCWs). Methods The study was conducted in Catalonia (Spain) during the first…
Targeting autophagy in disease: established and new strategies Open
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing cytosolic aggregated proteins, damaged organelles or invading microorganisms. Dysfunctional autophagy leads to pathological accumulation of the cargo,…
Psychosocial impact of the Covid-19 pandemic: Identification of most vulnerable populations Open
With the aim of analyzing the psychosocial impact of Covid-19 pandemic on society in general and health care workers in particular, we developed a 74-question survey questionnaire which was shared through social media. After analyzing 56,6…
COM-COVID project: results dataset Open
Results of the COM-COVID project, which aim is to assess the psychosocial impact of the Covid-19 pandemic first outbreak on general population and health care workers. These are the results of the 56,656 responses to a 74-question survey q…
COM-COVID project: results dataset Open
Results of the COM-COVID project, which aim is to assess the psychosocial impact of the Covid-19 pandemic first outbreak on general population and health care workers. These are the results of the 56,656 responses to a 74-question survey q…
CuBlock: a cross-platform normalization method for gene-expression microarrays Open
Motivation Cross-(multi)platform normalization of gene-expression microarray data remains an unresolved issue. Despite the existence of several algorithms, they are either constrained by the need to normalize all samples of all platforms t…
Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia Open
Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL cell interactions…
CuBlock: A cross-platform normalization method for gene-expression microarrays Open
Motivation Cross-(multi)platform normalization of gene-expression microarray data remains an unresolved issue. Despite the existence of several algorithms, they are either constrained by the need to normalize all samples of all platforms t…
In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm Open
From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that in some cases can be complicated by the severe acute respiratory syndrome, sepsis and septic shock, multiorgan failu…
View article: Network-Based Drug Discovery Identifies Statins as a Repurposing Agent to Improve Activity of Current Therapies in Chronic Lymphocytic Leukemia.
Network-Based Drug Discovery Identifies Statins as a Repurposing Agent to Improve Activity of Current Therapies in Chronic Lymphocytic Leukemia. Open
Background: Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. CLL cell interactions with the supportive tissue microenvironment play a critical role in disease pathogenesis. Despite new…
Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival Open
Background Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS‐AKI) is a unique type of renal failure that occurs at late stages of cirrhosis.…
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy Open
The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was ap…