Judith Hellman
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View article: Minor Cannabinoids CBD, CBG, CBN and CBC differentially modulate sensory neuron activation
Minor Cannabinoids CBD, CBG, CBN and CBC differentially modulate sensory neuron activation Open
The use of minor cannabinoids has been advanced, in part, by the idea of providing relief from pain and inflammation without the burden of unwanted psychogenic effects associated with Δ 9 THC. In this regard, investigators have focused on …
View article: Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons
Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons Open
Interest in nonpsychotropic cannabinoids like cannabinol (CBN) is increasing for pain therapy. This study delivers critical insights into CBN's metabolism and pharmacological effects, uncovering its therapeutic potential for pain reduction…
View article: Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice
Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice Open
Old patients are more likely to experience memory dysfunction than young patients after a stroke. It has been reported that brain astrocytes and microglia cause excessive removal of synapses at the acute and subacute stages of stroke, and …
View article: Inflammatory Bowel Disease from the Perspective of Newer Innate Immune System Biomarkers
Inflammatory Bowel Disease from the Perspective of Newer Innate Immune System Biomarkers Open
Background: The perspective of inflammatory bowel disease (IBD) has changed radically since the first decade of the 21st century, and the formerly monolithic components of IBD, ulcerative colitis (UC), and Crohn’s disease (CD) have undergo…
View article: Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation
Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation Open
Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of res…
View article: Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo
Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo Open
Introduction Patients with cirrhosis undergoing liver transplantation frequently exhibit systemic inflammation, coagulation derangements, and edema, indicating endothelial dysfunction. This syndrome may worsen after ischemia–reperfusion in…
View article: Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s
Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s Open
Cannabichromene (CBC) is a nonpsychoactive phytocannabinoid well-known for its wide-ranging health advantages. However, there is limited knowledge regarding its human metabolism following CBC consumption. This research aimed to explore the…
View article: Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species
Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species Open
Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and L…
View article: The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats
The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats Open
Introduction: Basic pharmacokinetic (PK) and pharmacodynamic models of the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are critical for developing translational models of exposure and toxicity. The neonatal perio…
View article: Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels Open
Background: The harmful vascular effects of smoking are well established, but the effects of chronic use of electronic cigarettes (e-cigarettes) on endothelial function are less understood. We hypothesized that e-cigarette use causes chang…
View article: Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive
Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive Open
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the use of CBG has recently witnessed a widespread surge because of i…
View article: A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery
A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery Open
Background Postoperative delirium is a common postsurgical complication in older patients and is associated with high morbidity and mortality. The objective of this study was to determine whether a digital cognitive assessment and patient …
View article: A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery Open
Ischemia reperfusion (IR) injury frequently results from processes that involve a transient period of interrupted blood flow. In the lung, isolated IR permits the experimental study of this specific process with continued alveolar ventilat…
View article: Metabolites of Cannabigerol (CBG) Generated by Human Cytochrome P450s are Bioactive
Metabolites of Cannabigerol (CBG) Generated by Human Cytochrome P450s are Bioactive Open
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the use of CBG has recently witnessed a widespread surge because of i…
View article: COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective
COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective Open
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defin…
View article: Isolation of Primary Mouse Lung Endothelial Cells
Isolation of Primary Mouse Lung Endothelial Cells Open
Endothelial cells play critical roles in the regulation of vascular tone, immunity, coagulation, and permeability. Endothelial dysfunction occurs in medical conditions including diabetes, atherosclerosis, sepsis, and acute lung injury. A r…
View article: Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies Open
OBJECTIVES: Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection. DATA SOURCES: Using a modified Delphi approach, the Surviving …
View article: ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages Open
Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D and 3D methods for directing human induced pluripotent stem cells (hiPSCs) into …
View article: Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation
Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation Open
Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During sepsis and acute inflammation, endothelial cells (ECs) underg…
View article: Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production
Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production Open
OBJECTIVES: Catecholaminergic vasopressors are the cornerstone of circulatory shock management. Nevertheless, catecholamines have problematic side effects, arousing a growing interest in noncatecholaminergic agents such as vasopressin or a…
View article: ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability
ERK1/2 Has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability Open
Endothelial cells play a major role in inflammatory responses to infection and sterile injury. Endothelial cells express Toll-like receptor 4 (TLR4) and are activated by LPS to express inflammatory cytokines/chemokines, and to undergo func…
View article: The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities*
The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities* Open
Objectives: Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data Sources: Ori…
View article: The surviving sepsis campaign: basic/translational science research priorities
The surviving sepsis campaign: basic/translational science research priorities Open
Objectives Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data sources Origi…
View article: Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury
Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury Open
Cannabis sativa and its principal components, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol, are increasingly being used to treat a variety of medical problems, including inflammatory conditions. Although studies suggest that the endoca…
View article: Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice
Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice Open
[This corrects the article DOI: 10.3389/fmicb.2019.00159.].