Isabela M. Benseñor
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View article: Early Cognitive Dispersion and Risk of Cognitive Impairment: Insights from the ELSA‐Brasil Study
Early Cognitive Dispersion and Risk of Cognitive Impairment: Insights from the ELSA‐Brasil Study Open
Background Neuropsychological assessments predominantly rely on mean‐level performance. However, middle‐aged and older adults may exhibit increased intraindividual cognitive variability (IICV) as an early sign of cognitive impairment, even…
View article: Racial and Sex differences in the association between anticholinergic burden and cognitive decline: longitudinal findigns from the Elsa‐Brasil Study
Racial and Sex differences in the association between anticholinergic burden and cognitive decline: longitudinal findigns from the Elsa‐Brasil Study Open
Background The impact of anticholinergic burden on cognition is a debated topic, with evidence linking it to cognitive decline in previous studies. However, few studies examine how these associations may differ by race and gender, particul…
View article: Inefficiencies identified in healthcare professional-to-patient handover practices for atrial fibrillation: a mixed-methods study in Brazil, China and Sri Lanka
Inefficiencies identified in healthcare professional-to-patient handover practices for atrial fibrillation: a mixed-methods study in Brazil, China and Sri Lanka Open
Introduction Information continuity and self-care are important for optimal management of atrial fibrillation (AF) to reduce complications (eg, stroke) and improve prognosis and patient satisfaction. This can be achieved through handover o…
View article: Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts
Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts Open
Objective The association of thyroid peroxidase antibodies (TPOAb) status with cardiovascular disease (CVD) risk, independent of thyroid function, remains unclear. We aimed to determine whether positive TPOAb is associated with increased C…
View article: Selenium levels as a sex-specific predictor of migraine in the ELSA-Brasil study
Selenium levels as a sex-specific predictor of migraine in the ELSA-Brasil study Open
Background Emerging evidence suggests a link between migraine and selenium (Se). Se is related to systemic low-grade inflammation and thyroid function, which in their turn are also linked to migraine. Thus, we aimed to explore these relati…
View article: A robust framework for harmonising health measures across international cohorts: Evidence from the COVID-19 pandemic
A robust framework for harmonising health measures across international cohorts: Evidence from the COVID-19 pandemic Open
Cross-national research on health trajectories requires harmonised measures that are valid and comparable. However, measurement scales often differ between cohorts in item content and cultural context. We present a structured framework to …
View article: The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study
The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study Open
Background: Recently, a new biomarker index that reflects inflammation and protein energy malnutrition has emerged as a predictor of mortality in cardiovascular diseases. The metabolic vulnerability index (MVX) derives from blood-based inf…
View article: Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 Open
Gates Foundation.
View article: Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease
Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease Open
Experimental studies have shown that urinary dipeptidyl peptidase 4 (uDPP4), unlike serum DPP4 (sDPP4) activity, correlates with proteinuria, serum creatinine, and left ventricular (LV) hypertrophy in chronic kidney disease (CKD) models, s…
View article: Socioeconomic and lifestyle factors associated with chronic musculoskeletal disorders in Brazil: a network analysis of a population-based study involving 87,648 Brazilian adults
Socioeconomic and lifestyle factors associated with chronic musculoskeletal disorders in Brazil: a network analysis of a population-based study involving 87,648 Brazilian adults Open
Background: Musculoskeletal disorders (MSKDs) are the leading cause of disability worldwide. The associations between socioeconomic and lifestyle factors and MSKDs have been widely studied in Europe and North America. However, little data …
View article: Coping with a chronic condition that requires lifelong medication: a qualitative study with people living with atrial fibrillation in São Paulo, Brazil
Coping with a chronic condition that requires lifelong medication: a qualitative study with people living with atrial fibrillation in São Paulo, Brazil Open
Objective To provide insight into how people cope with living with atrial fibrillation (AF) and taking oral anticoagulants (OACs), informing how services and healthcare delivery could be improved to offer the appropriate support patients r…
View article: Physical Activity and Survival After an Acute Coronary Syndrome: Data From the ERICO Study
Physical Activity and Survival After an Acute Coronary Syndrome: Data From the ERICO Study Open
Background : Due to enhancements in health care, the number of individuals who survive an acute coronary syndrome (ACS) event is rising. In this population, the impact of physical activity on long-term survival is still a matter of debate.…
View article: Effects of home-use transcranial direct current stimulation on clusters of depressive symptoms: an ancillary analysis of the PSYLECT study
Effects of home-use transcranial direct current stimulation on clusters of depressive symptoms: an ancillary analysis of the PSYLECT study Open
The association between tDCS and sleep improvement warrants further study. tDCS may be more effective for specific symptom clusters.
View article: Cognitive changes in post-stroke depression patients undergoing treatment with transcranial direct current stimulation (tDCS): an exploratory, ancillary analysis of a randomized, sham-controlled clinical trial
Cognitive changes in post-stroke depression patients undergoing treatment with transcranial direct current stimulation (tDCS): an exploratory, ancillary analysis of a randomized, sham-controlled clinical trial Open
We found no consistent evidence that tDCS significantly improved the cognitive domains. The bidirectional association with cognition analysis suggest that tDCS effects may vary based on depression severity and task complexity.
View article: Selenium intake, food sources, and associated factors in Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a cross-sectional study
Selenium intake, food sources, and associated factors in Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a cross-sectional study Open
BACKGROUND: Selenium is essential to human health. There are few reports on the analysis of selenium intake in the Brazilian population; however, data have shown that Brazilian are in the deficient range of consumption. OBJECTIVES: This st…
View article: Dietary patterns derived from three diet quality indices and associated factors: findings from the baseline of ELSA-Brasil
Dietary patterns derived from three diet quality indices and associated factors: findings from the baseline of ELSA-Brasil Open
The aim of this study was to describe dietary patterns using three diet quality indices and the associated factors among 15,081 participants from the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Dietary intak…
View article: A machine learning approach to predict positive coronary artery calcium scores in individuals with diabetes: a cross-sectional analysis of ELSA-Brasil baseline data
A machine learning approach to predict positive coronary artery calcium scores in individuals with diabetes: a cross-sectional analysis of ELSA-Brasil baseline data Open
It is unclear who benefits the most from atherosclerotic cardiovascular disease (ASCVD) screening imaging. This study aimed to identify features associated with positive coronary artery calcium scores (CACS) in individuals with diabetes us…
View article: Worsening quality of life in asthmatics, non-obstructed smokers and ACO during the COVID-19 pandemic in patients from the ELSA-Brazil
Worsening quality of life in asthmatics, non-obstructed smokers and ACO during the COVID-19 pandemic in patients from the ELSA-Brazil Open
During the pandemic, low quality of life levels were observed in all groups. IgE levels were higher in asthmatics, while the NOS group exhibited greater inflammation. Spirometry indicated lung function impairment in the asthma and ACO grou…
View article: Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease
Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease Open
Background Experimental studies have shown that urinary dipeptidyl peptidase 4 (uDPP4), unlike serum DPP4 (sDPP4) activity, correlates with proteinuria, serum creatinine, and left ventricular (LV) hypertrophy in 5/6 nephrectomized rats, su…
View article: Associations of comorbid headache disorders and depression with leisure‐time physical activity among 14,088 adults in The Brazilian Longitudinal Study of Adult Health
Associations of comorbid headache disorders and depression with leisure‐time physical activity among 14,088 adults in The Brazilian Longitudinal Study of Adult Health Open
Background While headache disorders are linked to low physical activity levels, the impact of depression on this relationship is unclear. Objective To assess how single and comorbid diagnoses of migraine and tension‐type headache (TTH) int…
View article: 6602 Classification of TSH Trajectories During Levothyroxine Treatment in the ELSA-Brasil Cohort
6602 Classification of TSH Trajectories During Levothyroxine Treatment in the ELSA-Brasil Cohort Open
Disclosure: M.D. Ettleson: None. G.C. Penna: Consulting Fee; Self; Ipsen, Bayer, Inc.. W. Wan: None. I.M. Bensenor: None. N. Laiteerapong: None. A.C. Bianco: Consulting Fee; Self; Abbvie. Classification of TSH Trajectories During Levothyro…
View article: The Predictive Value of the Triglycerides/HDL-Cholesterol Ratio for Diabetes Incidence
The Predictive Value of the Triglycerides/HDL-Cholesterol Ratio for Diabetes Incidence Open
Background: Type 2 diabetes mellitus (DM) is an important disease with an impact on public health globally. Early assessment is necessary with accessible markers, such as the TG/HDL ratio, in predicting DM. Methods: A total of 11,653 subje…