Judith Murray‐Rust
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View article: Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans
Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans Open
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry. Early autophosphorylation sites map to regions …
View article: Molecular Recognition of the Tes LIM2–3 Domains by the Actin-related Protein Arp7A
Molecular Recognition of the Tes LIM2–3 Domains by the Actin-related Protein Arp7A Open
Actin-related proteins (Arps) are a highly conserved family of proteins that have extensive sequence and structural similarity to actin. All characterized Arps are components of large multimeric complexes associated with chromatin or the c…
View article: Endothelial, Sympathetic, and Cardiac Function in Inherited (6 <i>R</i> )- <scp>l</scp> -Erythro-5,6,7,8-Tetrahydro- <scp>l</scp> -Biopterin Deficiency
Endothelial, Sympathetic, and Cardiac Function in Inherited (6 <i>R</i> )- <span>l</span> -Erythro-5,6,7,8-Tetrahydro- <span>l</span> -Biopterin Deficiency Open
Background— (6 R )-5,6,7,8-Tetrahydro- l -biopterin (BH4) is a cofactor for enzymes involved in catecholamine and nitric oxide generation whose synthesis is initiated by GTP cyclohydrolase I (GTPCH-1), encoded by GCH1 . In the absence of a…
View article: Dynamics of Lipid Transfer by Phosphatidylinositol Transfer Proteins in Cells
Dynamics of Lipid Transfer by Phosphatidylinositol Transfer Proteins in Cells Open
Of many lipid transfer proteins identified, all have been implicated in essential cellular processes, but the activity of none has been demonstrated in intact cells. Among these, phosphatidylinositol transfer proteins (PITP) are of particu…
View article: Structure of a Conserved Dimerization Domain within the F-box Protein Fbxo7 and the PI31 Proteasome Inhibitor
Structure of a Conserved Dimerization Domain within the F-box Protein Fbxo7 and the PI31 Proteasome Inhibitor Open
F-box proteins are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. Here we report a structural relationship between Fbxo7, a component of the SCF(Fbxo7) E3 ligase, and the proteasome inhibito…
View article: Structure and Chemical Inhibition of the RET Tyrosine Kinase Domain
Structure and Chemical Inhibition of the RET Tyrosine Kinase Domain Open
The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in Hirschsprung disease, whereas activating mutations in RET …
View article: Structure of XPF endonuclease from<i>A. pernix</i>
Structure of XPF endonuclease from<i>A. pernix</i> Open
MACROMOLECULES C223SUMO modification over the TDG dissociation from DNA has not been revealed yet.Simultaneously, the functional difference between SUMO-1 and SUMO-2/3 modification is also unclear if it exists.Here we solved the crystal st…
View article: Crystallization of the xeroderma pigmentosum group F endonuclease from<i>Aeropyrum pernix</i>
Crystallization of the xeroderma pigmentosum group F endonuclease from<i>Aeropyrum pernix</i> Open
The xeroderma pigmentosa group F protein (XPF) is a founding member of a family of 3'-flap endonucleases that play an essential role in nucleotide-excision repair, DNA replication and recombination. The XPF gene has been cloned from Aeropy…
View article: Phosphorylation of a Distinct Structural Form of Phosphatidylinositol Transfer Protein α at Ser166 by Protein Kinase C Disrupts Receptor-mediated Phospholipase C Signaling by Inhibiting Delivery of Phosphatidylinositol to Membranes
Phosphorylation of a Distinct Structural Form of Phosphatidylinositol Transfer Protein α at Ser166 by Protein Kinase C Disrupts Receptor-mediated Phospholipase C Signaling by Inhibiting Delivery of Phosphatidylinositol to Membranes Open
Phosphatidylinositol transfer protein alpha (PITPalpha) participates in the supply of phosphatidylinositol (PI) required for many cellular events including phospholipase C (PLC) beta and gamma signaling by G-protein-coupled receptors and r…
View article: The <i>Mycobacterium tuberculosis ino1</i> gene is essential for growth and virulence
The <i>Mycobacterium tuberculosis ino1</i> gene is essential for growth and virulence Open
Summary Inositol is utilized by Mycobacterium tuberculosis in the production of its major thiol and of essential cell wall lipoglycans. We have constructed a mutant lacking the gene encoding inositol‐1‐phosphate synthase ( ino1 ), which ca…
View article: <i>S</i> -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
<i>S</i> -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase Open
The enzyme dimethylarginine dimethylaminohydrolase (DDAH) hydrolyses asymmetrically methylated arginine residues that are endogenously produced inhibitors of nitric oxide synthases (NOS). We and others have proposed that DDAH activity is a…
View article: The Role of Tyrosine Residues in Fibroblast Growth Factor Receptor 1 Signaling in PC12 Cells
The Role of Tyrosine Residues in Fibroblast Growth Factor Receptor 1 Signaling in PC12 Cells Open
To assess the contribution of the intracellular domain tyrosine residues to the signaling capacity of fibroblast growth factor receptor 1 (FGFR1), stably transfected chimeras bearing the ectodomain of the platelet-derived growth factor rec…
View article: Structure–activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants
Structure–activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants Open
Upon stimulation with tumor necrosis factor (TNF), the TNF receptor (TNFR55) mediates a multitude of effects both in normal and in tumor cells. Clustering of the intracellular domain of the receptor, the so‐called death domain (DD), is res…
View article: Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding
Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding Open
Recombinant wild-type human IGF-1 and a C-region mutant in which residues 28-37 have been replaced by a 4-glycine bridge (4-Gly IGF-1) were secreted and purified from yeast. An IGF-1 analogue in which residues 29-41 of the C-region have be…
View article: Nerve growth factor: Structure/function relationships
Nerve growth factor: Structure/function relationships Open
Nerve growth factor (NGF), which has a tertiary structure based on a cluster of 3 cystine disulfides and 2 very extended, but distorted β‐hairpins, is the prototype of a larger family of neurotrophins. Prior to the availability of cloning …
View article: X-ray crystallographic studies on murine nerve growth factor
X-ray crystallographic studies on murine nerve growth factor Open
The largest and best characterised family of neurotrophic growth factors is that of nerve growth factor (NGF) and its relatives. In order to understand the relation of structure and function, we have undertaken X-ray analyses of murine NGF…
View article: Some studies on chlorocuprates
Some studies on chlorocuprates Open
The work in this thesis is concerned with alkylammonium chlorocuprates and their solid solutions. The stoichiometries and structures of various chlorocuprate anions are considered in terms of the influence of the size and shape of the cati…