Judith Sayers
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View article: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration Open
In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great…
View article: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration Open
In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great…
View article: Tolerability, toxicity, and outcomes following surgical and non-surgical approaches to the management of patients with locally advanced oesophageal squamous cell carcinoma: multicentre retrospective cohort study
Tolerability, toxicity, and outcomes following surgical and non-surgical approaches to the management of patients with locally advanced oesophageal squamous cell carcinoma: multicentre retrospective cohort study Open
Background Oesophageal squamous cell carcinoma is the predominant histopathological subtype of oesophageal cancer across the world, representing as many as 90% of all cases; however, within Western cohorts, it is a low-prevalence disease, …
View article: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration Open
In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great…
View article: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration Open
In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great…
View article: Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration
Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration Open
Aims In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of thi…
View article: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration Open
In humans, new-born infants can regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds great…
View article: Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration
Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration Open
In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this pro…
View article: Dissecting the global leadership initiative on malnutrition criteria in advanced cancer: Reduced intake vs. inflammation
Dissecting the global leadership initiative on malnutrition criteria in advanced cancer: Reduced intake vs. inflammation Open
The results suggest that the inflammatory component of GLIM appears superior compared to reduced intake in predicting OS and notably, a higher CRP threshold correlates with shorter OS. Therefore, whilst GLIM has multiple potential combinat…
View article: Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series
Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series Open
Background In patients receiving anti‐cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no systematic review of oncological endpoints in cancer cachexia (CC) trials. This review …
View article: Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series Open
Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers fea…
View article: Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series Open
Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selecte…
View article: Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series
Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series Open
The use of patient‐reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self‐report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review des…
View article: Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series Open
There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and evaluate endpoints …
View article: Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series Open
In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, it is not clea…
View article: 373. THE PROGNOSTIC IMPACT OF TIME DELAYS IN OESOPHAGEAL CANCER SURGERY: 10-YEAR EXPERIENCE OF A HIGH-VOLUME CENTRE
373. THE PROGNOSTIC IMPACT OF TIME DELAYS IN OESOPHAGEAL CANCER SURGERY: 10-YEAR EXPERIENCE OF A HIGH-VOLUME CENTRE Open
Background Over the last twenty years, treatment of oesophageal cancer has changed towards a multimodal approach to achieve better clinical outcomes. Detailed staging paradigms and neoadjuvant treatment have resulted in a longer time perio…
View article: SP6.2 The Prognostic Impact of Pre-Treatment Cachexia in Patients Undergoing Resectional Surgery for Oesophagogastric Malignancy: A Systematic Review, Meta-Analysis & Meta-Regression
SP6.2 The Prognostic Impact of Pre-Treatment Cachexia in Patients Undergoing Resectional Surgery for Oesophagogastric Malignancy: A Systematic Review, Meta-Analysis & Meta-Regression Open
Background Cancer cachexia is not purely an end-stage phenomenon and even influences the outcome of patients with potentially curative malignancies. This review aims to examine the effect of pre-treatment cachexia on survival in patients u…
View article: The prognostic impact of pre-treatment cachexia in resectional surgery for oesophagogastric cancer: a meta-analysis and meta-regression
The prognostic impact of pre-treatment cachexia in resectional surgery for oesophagogastric cancer: a meta-analysis and meta-regression Open
Background Cancer cachexia is not purely an end-stage phenomenon and can influence the outcomes of patients with potentially curable disease. This review examines the effect of pre-treatment cachexia on overall survival, in patients underg…
View article: The Impact of Acute Systemic Inflammation Secondary to Oesophagectomy and Anastomotic Leak on Computed Tomography Body Composition Analyses
The Impact of Acute Systemic Inflammation Secondary to Oesophagectomy and Anastomotic Leak on Computed Tomography Body Composition Analyses Open
This study aimed to longitudinally assess CT body composition analyses in patients who experienced anastomotic leak post-oesophagectomy. Consecutive patients, between 1 January 2012 and 1 January 2022 were identified from a prospectively m…
View article: Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration
Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration Open
In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this pro…
View article: Optimising Outcomes in Non Small Cell Lung Cancer: Targeting Cancer Cachexia
Optimising Outcomes in Non Small Cell Lung Cancer: Targeting Cancer Cachexia Open
Lung cancer is the commonest malignancy worldwide and the leading cause of cancer death. Half of patients with lung cancer present with advanced disease. The number of systemic therapies including immunotherapy and targeted treatment are r…
View article: Energy Projects, Social Licence, Public Acceptance and Regulatory Systems in Canada: A White Paper
Energy Projects, Social Licence, Public Acceptance and Regulatory Systems in Canada: A White Paper Open
It has become increasingly difficult in Canada to gain and sustain public acceptance of energy projects. Increased levels of protest, combined with traditional media and social media coverage of opposition, combine to suggest decreased pub…
View article: Energy Projects, Social Licence, Public Acceptance and Regulatory Systems in Canada: A White Paper
Energy Projects, Social Licence, Public Acceptance and Regulatory Systems in Canada: A White Paper Open
It has become increasingly difficult in Canada to gain and sustain public acceptance of energy projects. Increased levels of protest, combined with traditional media and social media coverage of opposition, combine to suggest decreased pub…