Judith Thoma
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View article: An in-silico approach towards multivariate acceptable ranges in biopharmaceutical manufacturing
An in-silico approach towards multivariate acceptable ranges in biopharmaceutical manufacturing Open
Multivariate interactions between process parameters can heavily impact product quality and process performance in biopharmaceutical manufacturing processes. Thus, multivariate interactions should be identified and appropriately controlled…
View article: Incorporating random effects in biopharmaceutical control strategies
Incorporating random effects in biopharmaceutical control strategies Open
Objective Random effects are often neglected when defining the control strategy for a biopharmaceutical process. In this article, we present a case study that highlights the importance of considering the variance introduced by random effec…
View article: Additional file 1 of Incorporating random effects in biopharmaceutical control strategies
Additional file 1 of Incorporating random effects in biopharmaceutical control strategies Open
Additional file 1. Anonymized PCS data.
View article: Additional file 2 of Incorporating random effects in biopharmaceutical control strategies
Additional file 2 of Incorporating random effects in biopharmaceutical control strategies Open
Additional file 2. Estimated effect sizes and variance ratios.
View article: Discreteness of cell–surface contacts affects spatio-temporal dynamics, adhesion, and proliferation of mouse embryonic stem cells
Discreteness of cell–surface contacts affects spatio-temporal dynamics, adhesion, and proliferation of mouse embryonic stem cells Open
The self-renewal and lineage-specific differentiation of stem cells are regulated by interactions with their microenvironments, called stem cell niche . Stem cells receive both biochemical and biophysical cues from their niche , which lead…
View article: Water modulates the lamellar structure and interlayer correlation of poly(perfluorooctyl acrylate) films: a specular and off-specular neutron scattering study
Water modulates the lamellar structure and interlayer correlation of poly(perfluorooctyl acrylate) films: a specular and off-specular neutron scattering study Open
Comb-like polymers with pendant-like perfluorocarbon side chains self-assemble into smectic lamellae and have been extensively used as water-repellent, hydrophobic coating materials characterized by large water contact angles ( θ > 120°). …
View article: Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser
Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser Open
Antimicrobial resistance is a major threat to public health. Although many commercial sanitisers contain a combination of cationic surfactants and aromatic alcohols, the physical mechanisms where these two substances bind to or how they di…
View article: Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells
Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells Open
Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells (HPCs, CD34+ cells), this report addresses whether this is caused by elevated glycoly…
View article: Nanofocused Scanning X-ray Fluorescence Microscopy Revealing an Effect of Heterozygous Hemoglobin S and C on Biochemical Activities in <i>Plasmodium falciparum</i>-Infected Erythrocytes
Nanofocused Scanning X-ray Fluorescence Microscopy Revealing an Effect of Heterozygous Hemoglobin S and C on Biochemical Activities in <i>Plasmodium falciparum</i>-Infected Erythrocytes Open
While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying biochemical mechanisms at the single cell level. Using nanofocused …
View article: Nanofocused Scanning X‑ray Fluorescence MicroscopyRevealing an Effect of Heterozygous Hemoglobin S and C on BiochemicalActivities in Plasmodium falciparum-Infected Erythrocytes
Nanofocused Scanning X‑ray Fluorescence MicroscopyRevealing an Effect of Heterozygous Hemoglobin S and C on BiochemicalActivities in Plasmodium falciparum-Infected Erythrocytes Open
While\nthere is ample evidence suggesting that carriers of heterozygous\nhemoglobin S and C are protected from life-threatening malaria, little\nis known about the underlying biochemical mechanisms at the single\ncell level. Using nanofocu…