Judith Wendler
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View article: Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota Open
The occurrence and spread of multidrug-resistant pathogens, especially bacteria from the ESKAPE panel, increases the risk to succumb to untreatable infections. We developed a novel antimicrobial peptide, Pam-3, with antibacterial and antib…
View article: Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria
Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria Open
The occurrence and spread of multidrug-resistant bacteria is a prominent health concern. To curb this urgent threat, new innovative strategies pursuing novel antimicrobial agents are of the utmost importance. Here, we unleashed the antimic…
View article: Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria
Ustekinumab is effective in biological refractory Crohn’s disease patients–regardless of approval study selection criteria Open
Ustekinumab is effective, safe and well tolerated in a highly therapy refractory patient cohort. Even though a reasonable number of patients did not meet ustekinumab approval study criteria, approval study results seem to be representative…
View article: Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide
Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide Open
Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a high demand for new innovative antimicrobial strategies. The host-defense peptide human beta-defensin 1 (hBD-1) is produced continuously by epit…
View article: Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments Open
Significance Paneth cells provide intestinal host defense against pathogens and control the healthy microbiota by secreting antimicrobial peptides. We show that the most abundant secreted Paneth cell products, human defensin HD-5 and HD-6,…
View article: Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1
Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1 Open
The antimicrobial peptide human β-defensin 1 (hBD1) is continuously produced by epithelial cells in many tissues. Compared to other defensins, hBD1 has only minor antibiotic activity in its native state. After reduction of its disulfide br…
View article: P489 Clinical experience with ustekinumab in selected Crohn's disease patients
P489 Clinical experience with ustekinumab in selected Crohn's disease patients Open
Ustekinumab – an interleukin-12/23 antibody has been shown to be efficient in moderately to active Crohns disease with a more favourable outcome in anti TNF naïve patients. After approval of the drug we first treated patients who were both…
View article: GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting
GLP-2 analog teduglutide significantly reduces need for parenteral nutrition and stool frequency in a real-life setting Open
Background: To evaluate the benefits of teduglutide in a real-life setting, we analyzed the data of 14 patients with short bowel syndrome treated with teduglutide. Additionally, we studied glucagon-like peptide 2 (GLP-2) receptor expressio…
View article: AB0763 Ustekinumab for the treatment of psoriatic arthritis – results of the first interim analysis of the non-interventional study sustain
AB0763 Ustekinumab for the treatment of psoriatic arthritis – results of the first interim analysis of the non-interventional study sustain Open