Judy K. VanSlyke
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View article: Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter
Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter Open
Crystallin proteins serve as both essential structural and as well as protective components of the ocular lens and are required for the transparency and light refraction properties of the organ. The mouse lens crystallin proteome is repres…
View article: Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin
Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin Open
Crystallin proteins serve as both essential structural and as well as protective components of the ocular lens and are required for the transparency and light refraction properties of the organ. The mouse lens crystallin proteome is repres…
View article: TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataract
TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataract Open
To cause vision-disrupting fibrotic secondary cataract (PCO), lens epithelial cells that survive cataract surgery must migrate to the posterior of the lens capsule and differentiate into myofibroblasts. During this process, the cells becom…
View article: Tonic ErbB signaling underlies TGFβ-induced activation of ERK and is required for lens cell epithelial to myofibroblast transition
Tonic ErbB signaling underlies TGFβ-induced activation of ERK and is required for lens cell epithelial to myofibroblast transition Open
Fibrosis is a major, but incompletely understood, component of many diseases. The most common vision-disrupting complication of cataract surgery involves differentiation of residual lens cells into myofibroblasts. In serum-free primary cul…
View article: ErbBs in Lens Cell Fibrosis and Secondary Cataract
ErbBs in Lens Cell Fibrosis and Secondary Cataract Open
Our findings support ErbB1 as a therapeutic target for fibrotic PCO, which could be leveraged to pharmaceutically preserve the vision of millions of patients with cataracts.
View article: Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells
Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells Open
Lens epithelial cells are bound to the lens extracellular matrix capsule, of which laminin is a major component. After cataract surgery, surviving lens epithelial cells are exposed to increased levels of fibronectin, and so we addressed wh…