Juehong Li
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View article: POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling? Open
Tendinous heterotopic ossification can cause pain and restricted joint mobility in affected areas, and it is a common and severe complication following tendon injuries. This condition significantly reduces the postoperative quality of life…
View article: Chiral Polylactic acid membranes attenuate Hyperinflammation for accelerating wound healing
Chiral Polylactic acid membranes attenuate Hyperinflammation for accelerating wound healing Open
Hyperinflammation poses a severe challenge in the treatment of chronic non-healing wounds, leading to rising morbidity and a substantial socio-economic burden. Targeting macrophages in non-healing wounds has drawn extensive interests owing…
View article: The IL-1β/NETs/AIM2 axis participates in the formation of trauma-induced heterotopic ossification by orchestrating crosstalk between neutrophils and macrophages
The IL-1β/NETs/AIM2 axis participates in the formation of trauma-induced heterotopic ossification by orchestrating crosstalk between neutrophils and macrophages Open
Our research not only reveals from a new perspective that the IL-1β-NETs-AIM2 axis participates in the formation of tHO by orchestrating crosstalk between neutrophils and macrophages, but also provides a novel approach for the future clini…
View article: Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A <scp>UK</scp> Biobank Cohort Study
Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A <span>UK</span> Biobank Cohort Study Open
Objectives Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are both prevalent inflammatory conditions within the population. Our objective was to explore the relationship between IBD and RA, while examining the role of infla…
View article: Chiral Arginine Modified Electrospun Membrane for Enhancing Tendon Healing
Chiral Arginine Modified Electrospun Membrane for Enhancing Tendon Healing Open
Tendon injury is a common motor system disease, impairing joint mobility, and lowering quality of life. Once damaged, tendon has a limited capacity for regeneration. Clinically, available therapeutic strategies have not achieved satisfacto…
View article: Tranexamic acid in patients with post-traumatic elbow stiffness: protocol for a randomised, double-blind, placebo-controlled trial investigating the effectiveness of tranexamic acid at reducing the recurrence of heterotopic ossification after open elbow arthrolysis
Tranexamic acid in patients with post-traumatic elbow stiffness: protocol for a randomised, double-blind, placebo-controlled trial investigating the effectiveness of tranexamic acid at reducing the recurrence of heterotopic ossification after open elbow arthrolysis Open
Introduction Exaggerated inflammatory response is one of the main mechanisms underlying heterotopic ossification (HO). It has been suggested that the antifibrinolytic drug tranexamic acid (TXA) can exert a significant anti-inflammatory eff…
View article: Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involving <scp>YAP</scp> /β‐catenin signaling
Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involving <span>YAP</span> /β‐catenin signaling Open
Heterotopic ossification occurs as a pathological ossification condition characterized by ectopic bone formation within soft tissues following trauma. Vascularization has long been established to fuel skeletal ossification during tissue de…
View article: <scp>KLF2</scp>/<scp>PPARγ</scp> axis contributes to trauma‐induced heterotopic ossification by regulating mitochondrial dysfunction
<span>KLF2</span>/<span>PPARγ</span> axis contributes to trauma‐induced heterotopic ossification by regulating mitochondrial dysfunction Open
Trauma‐induced heterotopic ossification (HO) is a complex disorder after musculoskeletal injury and characterized by aberrant extraskeletal bone formation. Recent studies shed light on critical role of dysregulated osteogenic differentiati…
View article: NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing
NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing Open
Heterotopic ossification (HO) represents an unwanted ossific wound healing response to the soft tissue injury which caused catastrophic limb dysfunction. Recent studies established the involvement of inflammation and cellular senescence in…
View article: Energy‐Supporting Enzyme‐Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy (Adv. Sci. 31/2022)
Energy‐Supporting Enzyme‐Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy (Adv. Sci. 31/2022) Open
Nanozyme Therapy In article number 2202542, Yuanming Ouyang, Yun Qian, Cunyi Fan, and co‐workers present a ceria nanozyme incorporated nanoporous scaffold with anisotropic and enhanced mechanical properties to explore a targeted energy‐sup…
View article: Energy‐Supporting Enzyme‐Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy
Energy‐Supporting Enzyme‐Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy Open
Tendon injury is a tricky and prevalent motor system disease, leading to compromised daily activity and disability. Insufficient regenerative capability and dysregulation of immune microenvironment are the leading causes of functional loss…
View article: Macrophage-derived TGF-βand VEGF promote the progression of trauma-induced heterotopic ossification
Macrophage-derived TGF-βand VEGF promote the progression of trauma-induced heterotopic ossification Open
ObjectiveHeterotopic ossification (HO) is a pathological bone formation process caused by musculoskeletal trauma. Our previous studies have indicated that macrophage inflammation is involved in traumatic HO formation. In this study, we val…
View article: The ROS‐responsive scavenger with intrinsic antioxidant capability and enhanced immunomodulatory effects for cartilage protection and osteoarthritis remission
The ROS‐responsive scavenger with intrinsic antioxidant capability and enhanced immunomodulatory effects for cartilage protection and osteoarthritis remission Open
Oxidative stress has close relationship with the progression of osteoarthritis and thus is an important therapeutic target. The use of antioxidants alone has common disadvantages such as low bioavailability, poor stability, and rapid joint…
View article: Inhibition of IL‐17 prevents the progression of traumatic heterotopic ossification
Inhibition of IL‐17 prevents the progression of traumatic heterotopic ossification Open
Traumatic heterotopic ossification (HO) is the abnormal formation of bone in soft tissues as a consequence of injury. However, the pathological mechanisms leading to traumatic HO remain unknown. Here, we report that aberrant expression of …
View article: Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult
Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult Open
Heterotopic ossification (HO) is one of the most intractable disorders following musculoskeletal injury and is characterized by the ectopic presence of bone tissue in the soft tissue leading to severe loss of function in the extremities. R…
View article: Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model
Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model Open
To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the fore…
View article: What constitutes a clinically important change in Mayo Elbow Performance Index and range of movement after open elbow arthrolysis?
What constitutes a clinically important change in Mayo Elbow Performance Index and range of movement after open elbow arthrolysis? Open
Aims This study aimed to determine the minimal detectable change (MDC), minimal clinically important difference (MCID), and substantial clinical benefit (SCB) under distribution- and anchor-based methods for the Mayo Elbow Performance Inde…
View article: Open elbow arthrolysis for post-traumatic elbow stiffness
Open elbow arthrolysis for post-traumatic elbow stiffness Open
Post-traumatic elbow stiffness is a disabling condition that remains challenging for upper limb surgeons. Open elbow arthrolysis is commonly used for the treatment of stiff elbow when conservative therapy has failed. Multiple questions com…
View article: <p>MicroRNA-21-3p Engineered Umbilical Cord Stem Cell-Derived Exosomes Inhibit Tendon Adhesion</p>
MicroRNA-21-3p Engineered Umbilical Cord Stem Cell-Derived Exosomes Inhibit Tendon Adhesion Open
Our results indicate that HUMSC-Exos may manipulate p65 activity by delivering low-abundance miR-21a-3p, ultimately inhibiting tendon adhesion. The findings may be promising for dealing with tendon adhesion.
View article: Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis
Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis Open
Wear particle-stimulated inflammatory bone destruction and the consequent aseptic loosening remain major postoperative problems for artificial joints. Studies have indicated that puerarin promotes osteogenesis and alleviates lipopolysaccha…
View article: Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization
Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization Open
Wear particle-induced periprosthetic inflammatory osteolysis and resultant aseptic loosening are major causes of orthopedic implant failure, for which there are no effective treatments other than revision surgery. Crocin, a carotenoid comp…