Juelu Wang
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View article: USP25 contributes to defective neurogenesis and cognitive impairments
USP25 contributes to defective neurogenesis and cognitive impairments Open
Both Down syndrome (DS) individuals and animal models exhibit hypo‐cellularity in hippocampus and neocortex indicated by enhanced neuronal death and compromised neurogenesis. Ubiquitin‐specific peptidase 25 ( USP25 ), a human chromosome 21…
View article: First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer
First Demonstration of Double Dissociation between COMT-Met158 and COMT-Val158 Cognitive Performance When Stressed and When Calmer Open
We present here the first evidence of the much-predicted double dissociation between the effect of stress on cognitive skills [executive functions (EFs)] dependent on prefrontal cortex (PFC) by catechol-O-methyltransferase (COMT) genotype.…
View article: Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene
Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene Open
Accumulation of amyloid β protein (Aβ) due to increased generation and/or impaired degradation plays an important role in Alzheimer's disease (AD) pathogenesis. In this report, we describe the identification of rare coding mutations in the…
View article: Transcriptional activation of USP16 gene expression by NFκB signaling
Transcriptional activation of USP16 gene expression by NFκB signaling Open
View article: Selective neurodegeneration in Alzheimer's disease and Parkinson's disease
Selective neurodegeneration in Alzheimer's disease and Parkinson's disease Open
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are featured by cholinergic and dopaminergic neuron loss, respectively. As a unique pathological hallmark of AD, neuritic plaques contain aggregated amyloid β protein (Aβ), generated fr…
View article: Regulation of LRRK2 promoter activity and gene expression by Sp1
Regulation of LRRK2 promoter activity and gene expression by Sp1 Open
This is the first study indicating that Sp1 signaling plays an important role in the regulation of human LRRK2 gene expression. It suggests that controlling LRRK2 level by manipulating Sp1 signaling may be beneficial to attenuate PD-relate…