Juergen Treckmann
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View article: Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection
Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection Open
Background. Acute liver injury is a life-threatening condition with disparate aetiology. Swift and adequate interdisciplinary treatment is essential to assure the best possible outcomes in these patients. Investigations to identify the cau…
View article: Prognostic factors of poor postoperative outcomes in gastrectomies
Prognostic factors of poor postoperative outcomes in gastrectomies Open
Background Gastric cancer is one of the most common cancers worldwide and is the third most common cause of cancer related death. Improving postoperative results by understanding risk factors which impact outcomes is important. The current…
View article: Lymph Node Staging in Perihilar Cholangiocarcinoma: The Key to the Big Picture
Lymph Node Staging in Perihilar Cholangiocarcinoma: The Key to the Big Picture Open
Klatskin tumors have a bad prognosis despite aggressive therapy. The role and extent of lymph node dissection during surgery is a matter of discussion. This retrospective study analyzes our current experience of surgical treatments in the …
View article: Supplementary Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Supplementary Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain Open
Contains: Supplemental Figures 1-7; Supplemental Tables 1 -3; Supplemental Methods
View article: Supplementary Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Supplementary Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain Open
Contains: Supplemental Figures 1-7; Supplemental Tables 1 -3; Supplemental Methods
View article: Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain Open
Gastrointestinal stromal tumors (GIST) harboring activating mutations of PDGFRA respond to imatinib, with the notable exception of the most common mutation, D842V. Avapritinib is a novel, potent KIT/PDGFRA inhibitor with substantial clinic…
View article: Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Data from Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain Open
Gastrointestinal stromal tumors (GIST) harboring activating mutations of PDGFRA respond to imatinib, with the notable exception of the most common mutation, D842V. Avapritinib is a novel, potent KIT/PDGFRA inhibitor with substantial clinic…
View article: Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
PDF - 42K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in cell lines.
View article: Data from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Data from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet-derived growth factor receptor α(PDGFRA), which can be therapeutically targeted by tyrosine kinase inhibitors (TKI) such as imatinib. Despi…
View article: Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
PDF - 42K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in cell lines.
View article: Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
PDF - 41K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in xenografts.
View article: Data from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Data from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet-derived growth factor receptor α(PDGFRA), which can be therapeutically targeted by tyrosine kinase inhibitors (TKI) such as imatinib. Despi…
View article: Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors Open
PDF - 41K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in xenografts.
View article: Preoperative computed tomography volumetry and graft weight estimation of left lateral segment in pediatric living donor liver transplantation
Preoperative computed tomography volumetry and graft weight estimation of left lateral segment in pediatric living donor liver transplantation Open
Introduction: Liver volumetry based on a CT-Scan is widely used for estimating liver volume before any liver resection, especially for pediatric living donor liver transplantation (LDLT). The "One-to-one" conversion rule for liver volume t…
View article: Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3
Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3 Open
The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses is not well understood. Here, primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic stel…
View article: HTK‐N as a new preservation solution for human kidney preservation: Results of a pilot randomized controlled clinical phase II trial in living donor transplantation
HTK‐N as a new preservation solution for human kidney preservation: Results of a pilot randomized controlled clinical phase II trial in living donor transplantation Open
Background HTK‐N was developed based on the traditional HTK preservation solution, resulting in stronger protection against reactive oxygen species as well as better tolerance to hypothermia and ischemia. Aim of the present study was to co…
View article: Small donors for small recipients – excellent growth and long‐term function of single kidney grafts
Small donors for small recipients – excellent growth and long‐term function of single kidney grafts Open
Small-donor kidneys (≤20 kg donor weight, SDK) are preferably transplanted en bloc in adults. Concerns about thrombotic complications or hyperfiltration hinder their use in children, particularly as single grafts. Low centre experience and…
View article: Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain Open
Gastrointestinal stromal tumors (GIST) harboring activating mutations of PDGFRA respond to imatinib, with the notable exception of the most common mutation, D842V. Avapritinib is a novel, potent KIT/PDGFRA inhibitor with substantial clinic…
View article: Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation Open
Background. Controlled oxygenated rewarming (COR) has been shown to be a feasible and safe method in clinical practice and to reduce peak serum transaminases after liver transplantation. This study aimed to demonstrate further clinical exp…
View article: Hepatitis B Virus Particles Activate Toll‐Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes
Hepatitis B Virus Particles Activate Toll‐Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes Open
BACKGROUND AND AIMS To date, conflicting data exist as to whether hepatitis B virus (HBV) has the ability to induce innate immune responses. Here, we investigated cellular changes after the first contact between HBV and primary human hepat…
View article: Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis
Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis Open
BACKGROUND Germany has the highest rate of patients dying or becoming unfit for transplant while waitlisted within the Eurotransplant region. Therefore, the aim of the current study was to analyze mortality as well as risk factors for mort…