Juhyeon Jo
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View article: Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling
Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling Open
Hutchinson–Gilford progeria syndrome, caused by a mutation in the LMNA gene, leads to increased levels of truncated prelamin A, progerin, in the nuclear membrane. The accumulation of progerin results in defective nuclear morphology and is …
View article: Molecular Regulators of Cellular Mechanoadaptation at Cell–Material Interfaces
Molecular Regulators of Cellular Mechanoadaptation at Cell–Material Interfaces Open
Diverse essential cellular behaviors are determined by extracellular physical cues that are detected by highly orchestrated subcellular interactions with the extracellular microenvironment. To maintain the reciprocity of cellular responses…
View article: SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation Open
Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. However, the underlying mecha…