Jeong Ho Seok
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View article: SAT-408 Characterization of a Novel Patient-derived EEFSEC Affecting Selenoprotein Synthesis and Thyroid Hormone Conversion
SAT-408 Characterization of a Novel Patient-derived EEFSEC Affecting Selenoprotein Synthesis and Thyroid Hormone Conversion Open
Disclosure: M. Noh: None. S. Erdenebileg: None. C. Park: None. Y. Han: None. J. Cha: None. T. Aoki: None. J. Kim: None. M. Kang: None. J. Yoo: None. M. Murakami: None. H. Lee: None. S. Lee: None. Thyroid hormone is a key regulator of metab…
View article: Natural Product-Derived Drugs: Structural Insights into Their Biological Mechanisms
Natural Product-Derived Drugs: Structural Insights into Their Biological Mechanisms Open
Natural product-derived drugs represent a cornerstone of modern pharmacotherapy, with many serving as essential therapeutic agents across diverse medical conditions. Recent advances in structural biology have provided unprecedented insight…
View article: Quercetin: Molecular Insights into Its Biological Roles
Quercetin: Molecular Insights into Its Biological Roles Open
Quercetin, a prevalent plant flavonoid, demonstrates many biological functions through its interaction with distinct protein targets. Recent structural investigations of protein–quercetin complexes have elucidated the molecular mechanism b…
View article: A humanized ACE2 mouse model recapitulating age‐ and sex‐dependent immunopathogenesis of COVID‐19
A humanized ACE2 mouse model recapitulating age‐ and sex‐dependent immunopathogenesis of COVID‐19 Open
In the ongoing battle against coronavirus disease 2019 (COVID‐19), understanding its pathogenesis and developing effective treatments remain critical challenges. The creation of animal models that closely replicate human infection stands a…
View article: Expression, purification, and crystallization of human CK2α in complex with the natural flavonoid quercetin
Expression, purification, and crystallization of human CK2α in complex with the natural flavonoid quercetin Open
Over 300 polypeptide substrates can undergo catalysis by the constitutively active Ser/Thr kinase, human casein kinase 2 alpha (hCK2α).Quercetin, a naturally occurring polyphenolic compound, is well-known for inhibiting hCK2α, thereby regu…
View article: Supplementary Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
Supplementary Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization Open
Figure S1-S6, Table S1-S7
View article: Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization Open
ErbB3, a member of the ErbB receptor family, is a potent mediator in the development and progression of cancer, and its activation plays pivotal roles in acquired resistance against anti-EGFR therapies and other standard-of-care therapies.…
View article: Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization Open
ErbB3, a member of the ErbB receptor family, is a potent mediator in the development and progression of cancer, and its activation plays pivotal roles in acquired resistance against anti-EGFR therapies and other standard-of-care therapies.…
View article: Supplementary Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
Supplementary Data from A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization Open
Figure S1-S6, Table S1-S7
View article: Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants
Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants Open
Coronavirus disease 2019, caused by SARS-CoV-2, remains an on-going pandemic, partly due to the emergence of variant viruses that can “break-through” the protection of the current vaccines and neutralizing antibodies (nAbs), highlighting t…
View article: A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization
A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization Open
ErbB3, a member of the ErbB receptor family, is a potent mediator in the development and progression of cancer, and its activation plays pivotal roles in acquired resistance against anti-EGFR therapies and other standard-of-care therapies.…
View article: Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2
Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2 Open
A protein binder with a desired epitope and binding affinity is critical to the development of therapeutic agents. Here we present computationally-guided design and affinity improvement of a protein binder recognizing a specific site on do…
View article: Direct binding of TFEα opens DNA binding cleft of RNA polymerase
Direct binding of TFEα opens DNA binding cleft of RNA polymerase Open
Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP, RNAP-…
View article: Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2
Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2 Open
A protein binder with a desired epitope and binding affinity is critical to the development of therapeutic agents. Here we present computationally-guided design and affinity improvement of a protein binder recognizing a specific site on do…
View article: A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana
A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana Open
A smoke-derived compound, karrikin (KAR), and an endogenous but as yet unidentified KARRIKIN INSENSITIVE2 (KAI2) ligand (KL) have been identified as chemical cues in higher plants that impact on multiple aspects of growth and development. …
View article: Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction
Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction Open
The epithelial-mesenchymal transition (EMT) is implicated in tumorigenesis and cancer progression, and canonical Wnt signaling tightly controls Snail, a key transcriptional repressor of EMT. While the suppression of canonical Wnt signaling…
View article: Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif
Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif Open
A novel light-driven chloride-pumping rhodopsin (ClR) containing an ‘NTQ motif’ in its putative ion conduction pathway has been discovered and functionally characterized in a genomic analysis study of a marine bacterium. Here we report the…
View article: Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation
Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation Open
Death receptor (DR) ligation elicits two different modes of cell death (necroptosis and apoptosis) depending on the cellular context. By screening a plant extract library from cells undergoing necroptosis or apoptosis, we identified a wate…
View article: Monomerization and <scp>ER</scp> Relocalization of <scp>GRASP</scp> Is a Requisite for Unconventional Secretion of <scp>CFTR</scp>
Monomerization and <span>ER</span> Relocalization of <span>GRASP</span> Is a Requisite for Unconventional Secretion of <span>CFTR</span> Open
Induction of endoplasmic reticulum ( ER )‐to‐Golgi blockade or ER stress induces Golgi reassembly stacking protein ( GRASP )‐mediated, Golgi‐independent unconventional cell‐surface trafficking of the folding‐deficient ΔF508 ‐cystic fibrosi…