Additively manufactured drug products, typically produced using small-scale, on-demand batch mode, require rapid and non-destructive quantification methods. A tunable modular design (TMD) approach combining porous polymeric freeze-dried modules and an additive manufacturing method, inkjet printing, was proposed in an earlier study to fabricate accurate and patient-tailored doses of an antidepressant citalopram hydrobromide. This approach addresses the unmet medical needs associated with antidepressant tapering. No…

Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low concentrations, the addition of MgSt substantially affects the final tablet properties. Its impact is further not only concentration dependent but also varies with exposure of the formulation to shear, which worst-case results in over-lubrication. The presented study investigated the…

This study aimed to investigate the effect of the manufacturing process, composition, and storage on the long-term physical stability of antidepressant citalopram hydrobromide (CHB) in oral solid foams as personalized drug delivery systems. Hydroxypropyl methylcellulose (HPMC) was used as the polymer matrix former, whereas glycerol and polysorbate 20 as liquid starting materials, and poly(ethylene oxide) 4000 (PEO 4000) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) as solid star…

Amino acids (AAs) have been employed as excipients in spray-dried (SD) protein formulations due to their stabilizing effects and particle engineering abilities. However, the research focusing on the influence of AAs on the tabletability of SD protein powders is still limited. The aim of this study was to investigate the effects of five diverse AAs, arginine hydrochloride (Arg·HCl), leucine (Leu), glycine (Gly), tryptophan (Trp) and sodium aspartate (Asp·Na), on the compaction behavior and stability of SD trypsin/l…

A novel method for the fabrication of flexible and precise doses of an antidepressant, citalopram hydrobromide (CHB), utilizing two approaches of incorporating CHB into the dosage form, was introduced in an earlier study. This method, called tunable modular design (TMD), employs CHB-preloaded modules done by freeze-drying together with inkjet printing of CHB-containing ink onto the modules. In this study, near-infrared chemical imaging (NIR-CI) was utilized to visualize the distribution of CHB both on the printed …