Julia A. Brown
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View article: Gut bacteria–derived serotonin promotes immune tolerance in early life
Gut bacteria–derived serotonin promotes immune tolerance in early life Open
The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remain largely undefined. Here, we demonstrate that the neonatal gut is uniquely enri…
View article: Evaluating the Safety of West Nile Virus Immunity During Congenital Zika Virus Infection in Mice
Evaluating the Safety of West Nile Virus Immunity During Congenital Zika Virus Infection in Mice Open
Antibody-dependent enhancement (ADE) is a phenomenon that occurs when cross-reactive antibodies generated from a previous flaviviral infection increase the pathogenesis of a related virus. Zika virus (ZIKV) is the most recent flavivirus in…
View article: Maternal Microbiome and Infections in Pregnancy
Maternal Microbiome and Infections in Pregnancy Open
Pregnancy induces unique changes in maternal immune responses and metabolism. Drastic physiologic adaptations, in an intricately coordinated fashion, allow the maternal body to support the healthy growth of the fetus. The gut microbiome pl…
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein
Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein Open
Zika virus (ZIKV) is a global health threat causing severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Here, we analyzed the human monoclonal antibody response to acute ZIKV infection and fo…
View article: Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides
Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides Open
The ability to protect vulnerable populations such as pregnant women and children from Zika virus and other arbovirus infections is essential to preventing the devastating complications induced by these viruses. One class of antiviral ther…
View article: The antiparasitic drug atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides.
The antiparasitic drug atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides. Open
Arthropod-borne viruses represent a significant public health threat worldwide yet there are few antiviral therapies or prophylaxis targeting these pathogens. In particular, the development of novel antivirals for high-risk populations suc…
View article: P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model
P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model Open
Patients who are chronically infected with HIV-1 experience sequelae related to chronic inflammation. The mechanisms of this inflammation have not been elucidated. Here, we describe a class of drugs that target the P2X proinflammatory sign…
View article: P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model
P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model Open
HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging literature has implicated pro-inflammatory purinergic re…
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis Open
West Nile virus (WNV) is a mosquito-transmitted flavivirus that can cause debilitating encephalitis. To delineate the mechanisms behind this pathology, we studied Ccr7-deficient mice, which afforded us the capacity to study infection in mi…
View article: Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity Open
One antibody for all and all antibodies for one Antibodies against related flavi-viruses such as dengue (DENV) and West Nile (WNV) can cross-react with Zika virus (ZIKV) and could thereby increase disease severity. Bardina et al. tested wh…
View article: A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses
A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses Open
Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas, causing large human outbreaks associated with fetal abnormalities and neurologi…
View article: IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults
IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults Open
Recovery of thymopoiesis is critical for immune reconstitution after HSCT. IL-7 and SCF are two major thymotropic cytokines. We investigated whether the kinetics of circulating levels of these cytokines might provide insight into the prolo…