Julia B. Lewis
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View article: Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis
Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis Open
Background and Aims Blood pressure (BP) lowering reduces cardiovascular disease (CVD) risk; however, the benefits of treating patients with normal systolic BP but elevated diastolic BP remain uncertain. Methods Data from 51 randomized cont…
View article: Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure
Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Open
Sotagliflozin improved symptoms, physical limitations, and quality of life within 4 months after worsening HF, with consistent benefits across baseline demographic and clinical characteristics. (Effect of Sotagliflozin on Cardiovascular Ev…
View article: Vascular Endothelial Growth Factor–B Blockade with CSL346 in Diabetic Kidney Disease
Vascular Endothelial Growth Factor–B Blockade with CSL346 in Diabetic Kidney Disease Open
Key Points The vascular endothelial growth factor B inhibitor CSL346 (8 or 16 mg/kg q4w) did not reduce urinary albumin-creatinine ratio at week 16 versus placebo in patients with type 2 diabetes mellitus and diabetic kidney disease. CSL34…
View article: Cognitive impairment among alcohol treatment service users in South Wales: an exploratory examination of typologies of behaviour, impairment, and service attendance
Cognitive impairment among alcohol treatment service users in South Wales: an exploratory examination of typologies of behaviour, impairment, and service attendance Open
Introduction Alcohol dependence is a global issue with many negative consequences, including alcohol-related brain damage (ARBD). Assessment of the sociodemographic and cognitive characteristics of individuals with confirmed or suspected A…
View article: Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease
Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease Open
National Institutes of Health. (PROSPERO: CRD42022307589).
View article: Association between Acute Declines in eGFR during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes
Association between Acute Declines in eGFR during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes Open
Key Points Renin-angiotensin system inhibition was favorable for risk of kidney failure (compared with 0% decline with use of placebo or other agents) up to declines in eGFR of 13% over a 3-month period. Relation between eGFR decline after…
View article: Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study
Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study Open
Background Hospital-onset bacteraemia and fungaemia (HOB) is being explored as a surveillance and quality metric. The objectives of the current study were to determine sources and preventability of HOB in hospitalised patients in the USA a…
View article: Effect of Sotagliflozin on Early Mortality and Heart Failure-Related Events
Effect of Sotagliflozin on Early Mortality and Heart Failure-Related Events Open
Starting sotagliflozin before discharge in patients with type 2 diabetes hospitalized for WHF significantly decreased cardiovascular deaths and HF events through 30 and 90 days after discharge, emphasizing the importance of beginning sodiu…
View article: Early Outcomes of SARS-CoV-2 Infection in a Multisite Prospective Cohort of Inpatient Veterans
Early Outcomes of SARS-CoV-2 Infection in a Multisite Prospective Cohort of Inpatient Veterans Open
Background Over 870 000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have occurred among Veterans Health Administration users, and 24 000 have resulted in death. We examined early outcomes of SARS-CoV-2 infection…
View article: Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD
Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD Open
Significance Statement Changes in albuminuria and GFR slope are individually used as surrogate end points in clinical trials of CKD progression, and studies have demonstrated that each is associated with treatment effects on clinical end p…
View article: Social Determinants of Health and Their Impact on the Black Race Coefficient in Serum Creatinine–Based Estimation of GFR
Social Determinants of Health and Their Impact on the Black Race Coefficient in Serum Creatinine–Based Estimation of GFR Open
Background The cause for differences in serum creatinine between Black and non-Black individuals incorporated into prior GFR-estimating equations is not understood. We explored whether social determinants of health can account for this dif…
View article: Evaluation of Variation in the Performance of GFR Slope as a Surrogate End Point for Kidney Failure in Clinical Trials that Differ by Severity of CKD
Evaluation of Variation in the Performance of GFR Slope as a Surrogate End Point for Kidney Failure in Clinical Trials that Differ by Severity of CKD Open
Background The GFR slope has been evaluated as a surrogate end point for kidney failure in meta-analyses on a broad collection of randomized controlled trials (RCTs) in CKD. These analyses evaluate how accurately a treatment effect on GFR …
View article: Diabetic Proteinuria Revisited: Updated Physiologic Perspectives
Diabetic Proteinuria Revisited: Updated Physiologic Perspectives Open
Albuminuria, a hallmark of diabetic nephropathy, reflects not only injury and dysfunction of the filtration apparatus, but is also affected by altered glomerular hemodynamics and hyperfiltration, as well as by the inability of renal tubula…
View article: The Paradox of the Frontal Lobe Paradox. A Scoping Review
The Paradox of the Frontal Lobe Paradox. A Scoping Review Open
The “frontal lobe paradox” highlights a phenomenon in which a subset of patients who possess frontal lobe damage and exhibit marked impairments in everyday life are still able to able to verbally describe a logical course of action relatin…
View article: Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression
Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression Open
Background Acute changes in GFR can occur after initiation of interventions targeting progression of CKD. These acute changes complicate the interpretation of long-term treatment effects. Methods To assess the magnitude and consistency of …
View article: Anti-Phospholipase A2 Receptor in Nonlupus Patients with Membranous Nephropathy and Crescents
Anti-Phospholipase A2 Receptor in Nonlupus Patients with Membranous Nephropathy and Crescents Open
Introduction: Anti-phospholipase A2 receptor (PLA2R) is detected in approximately 70% of biopsies of “primary” membranous nephropathy (MN). Crescents in MN in nonlupus patients suggest additional injury, such as antineutrophil cytoplasmic …
View article: Effect of Sotagliflozin on Total Hospitalizations in Patients With Type 2 Diabetes and Worsening Heart Failure
Effect of Sotagliflozin on Total Hospitalizations in Patients With Type 2 Diabetes and Worsening Heart Failure Open
Sanofi at initiation and Lexicon Pharmaceuticals at completion.
View article: Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease
Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease Open
In patients with diabetes and chronic kidney disease, with or without albuminuria, sotagliflozin resulted in a lower risk of the composite of deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for hear…
View article: Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure
Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure Open
In patients with diabetes and recent worsening heart failure, sotagliflozin therapy, initiated before or shortly after discharge, resulted in a significantly lower total number of deaths from cardiovascular causes and hospitalizations and …
View article: Laboratory Testing, Diagnostic Coding, and Treatment for Electronic Identification of <i>Clostridioides difficile</i> Infection
Laboratory Testing, Diagnostic Coding, and Treatment for Electronic Identification of <i>Clostridioides difficile</i> Infection Open
Background: Accurate identification of Clostridioides difficile infections (CDIs) from electronic data sources is important for surveillance. We evaluated how frequently laboratory findings were supported by diagnostic coding and treatment…