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View article: Laser Desorption-Rapid Evaporative Ionization Mass Spectrometry (LD-REIMS): A New Tool for the High-Throughput Metabolomic and Lipidomic Profiling of Live Cells
Laser Desorption-Rapid Evaporative Ionization Mass Spectrometry (LD-REIMS): A New Tool for the High-Throughput Metabolomic and Lipidomic Profiling of Live Cells Open
Understanding the dynamic cellular metabolism is essential for gaining deeper insights into inter- and intracellular functions. In recent years, mass spectrometry (MS) has become the technology of choice for the biochemical characterizatio…
View article: Towards Real-Time Industry-Proof Pork Breed and Boar Taint Classification using Rapid Evaporative Ionisation Mass Spectrometry (REIMS)
Towards Real-Time Industry-Proof Pork Breed and Boar Taint Classification using Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Open
To help counteract food fraud and meet consumer expectations, the pork industry requires reliable quality-monitoring and traceability systems. In this context, Rapid Evaporative Ionization Mass Spectrometry (REIMS) could be rolled out as a…
View article: Subcellular-Resolution Molecular Pathology by Laser Ablation–Rapid Evaporative Ionization Mass Spectrometry
Subcellular-Resolution Molecular Pathology by Laser Ablation–Rapid Evaporative Ionization Mass Spectrometry Open
This work demonstrates the combination of ambient laser ablation (LA) with in-source surface-induced declustering, originally developed for rapid evaporative ionization mass spectrometry (REIMS). This combination, termed laser ablation REI…
View article: Sensory Classification of Brazilian <i>Coffea arabica</i> by Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry and Machine Learning Algorithms
Sensory Classification of Brazilian <i>Coffea arabica</i> by Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry and Machine Learning Algorithms Open
Brazil plays an important role in coffee quality assessment since it is the top producer and exporter. New technologies must be developed to increase production and ensure product quality. Thus, this study presents an application of laser-…
View article: Towards Real-Time Industry-Proof Pork Breed and Boar Taint Classification Using Rapid Evaporative Ionisation Mass Spectrometry (Reims)
Towards Real-Time Industry-Proof Pork Breed and Boar Taint Classification Using Rapid Evaporative Ionisation Mass Spectrometry (Reims) Open
View article: Unlocking Female Fertility with a Specific Reproductive Exercise Program: Protocol of a Randomized Controlled Clinical Trail
Unlocking Female Fertility with a Specific Reproductive Exercise Program: Protocol of a Randomized Controlled Clinical Trail Open
According to World Health Organization (WHO) data, 16% of people are affected by infertility across the globe. One underlying factor is the age-related decline of ovarian reserve (DOR), which can lead to a higher chance of infertility and …
View article: High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin-Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS)
High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin-Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS) Open
Background: Building extensive drug candidate libraries as early in the development pipeline as possible, with high-throughput in vitro absorption, distribution, metabolism, and excretion (ADME) profiling, is crucial for the selection of l…
View article: Testing of rapid evaporative mass spectrometry for histological tissue classification and molecular diagnostics in a multi-site study
Testing of rapid evaporative mass spectrometry for histological tissue classification and molecular diagnostics in a multi-site study Open
Background While REIMS technology has successfully been demonstrated for the histological identification of ex-vivo breast tumor tissues, questions regarding the robustness of the approach and the possibility of tumor molecular diagnostics…
View article: Characterisation of Canine and Feline Breast Tumours, Their Metastases, and Corresponding Primary Cell Lines Using LA-REIMS and DESI-MS Imaging
Characterisation of Canine and Feline Breast Tumours, Their Metastases, and Corresponding Primary Cell Lines Using LA-REIMS and DESI-MS Imaging Open
Breast cancer, a complex disease with a significant prevalence to form metastases, necessitates novel therapeutic strategies to improve treatment outcomes. Here, we present the results of a comparative molecular study of primary breast tum…
View article: Enabling Cellular Resolution Molecular Pathology for Surgical Interventions Using Laser Desorption – Rapid Evaporative Ionization Mass spectrometry
Enabling Cellular Resolution Molecular Pathology for Surgical Interventions Using Laser Desorption – Rapid Evaporative Ionization Mass spectrometry Open
Laser desorption ionization (LDI) is generally considered to be an inferior ionization modality to matrix assisted LDI (MALDI), providing information solely on lipids with low sensitivity. The current study demonstrates that the combinatio…
View article: Sample preparation free tissue imaging using Laser Desorption – Rapid Evaporative Ionisation Mass spectrometry (LD-REIMS)
Sample preparation free tissue imaging using Laser Desorption – Rapid Evaporative Ionisation Mass spectrometry (LD-REIMS) Open
Laser desorption ionisation (LDI) is generally considered to be an inferior ionisation modality to matrix assisted LDI (MALDI), providing information solely on lipids with low sensitivity. The current study demonstrates that the combinatio…
View article: Sample preparation free tissue imaging using Laser Desorption – Rapid Evaporative Ionisation Mass spectrometry (LD-REIMS)
Sample preparation free tissue imaging using Laser Desorption – Rapid Evaporative Ionisation Mass spectrometry (LD-REIMS) Open
Laser desorption ionisation (LDI) is generally considered to be an inferior ionisation modality to matrix assisted LDI (MALDI), providing information solely on lipids with low sensitivity. The current study demonstrates that the combinatio…
View article: Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)—A Prospective Pilot Study of Diagnostic Accuracy
Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)—A Prospective Pilot Study of Diagnostic Accuracy Open
Introduction: Delays in the diagnosis and treatment of endometrial cancer negatively impact patient survival. The aim of this study was to establish whether rapid evaporative ionisation mass spectrometry using the iKnife can accurately dis…
View article: Harmonization of Rapid Evaporative Ionization Mass Spectrometry Workflows across Four Sites and Testing Using Reference Material and Local Food-Grade Meats
Harmonization of Rapid Evaporative Ionization Mass Spectrometry Workflows across Four Sites and Testing Using Reference Material and Local Food-Grade Meats Open
Rapid evaporative ionization mass spectrometry (REIMS) is a direct tissue metabolic profiling technique used to accurately classify tissues using pre-built mass spectral databases. The reproducibility of the analytical equipment, methodolo…
View article: Rapid detection of SARS-CoV2 by Ambient Mass Spectrometry Techniques
Rapid detection of SARS-CoV2 by Ambient Mass Spectrometry Techniques Open
Ambient Ionisation Mass Spectrometry techniques: Desorption Electrospray Ionisation (DESI) and Laser Desorption – Rapid Evaporative Ionisation Mass Spectrometry (LD-REIMS) were used to detect the SARS-CoV-2 in dry nasal swabs. 45 patients …
View article: The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease
The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease Open
Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also…
View article: Rapid detection and specific identification of offals within minced beef samples utilising ambient mass spectrometry
Rapid detection and specific identification of offals within minced beef samples utilising ambient mass spectrometry Open
View article: First implementation of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) for the at-line screening of boar carcasses in the slaughterhouse
First implementation of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) for the at-line screening of boar carcasses in the slaughterhouse Open
View article: At-line boar taint classification by means of Rapid Evaporative Ionisation Mass Spectrometry (REIMS)
At-line boar taint classification by means of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Open
Increasing awareness of animal welfare has led to a European incentive to ban the surgical castration of piglets. A valid alternative for castration is the rearing of entire male pigs, but this allows the (re)occurrence of boar taint, an o…
View article: Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/Ionization Mass Spectrometry Technology
Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/Ionization Mass Spectrometry Technology Open
View article: The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS)
The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS) Open
Real-time tissue diagnosis using mass spectrometry coupled with standard surgical electro-diathermy, the iKnife.
View article: A real time metabolomic profiling approach to detecting fish fraud using rapid evaporative ionisation mass spectrometry
A real time metabolomic profiling approach to detecting fish fraud using rapid evaporative ionisation mass spectrometry Open
View article: Effect of Electrode Geometry on the Classification Performance of Rapid Evaporative Ionization Mass Spectrometric (REIMS) Bacterial Identification
Effect of Electrode Geometry on the Classification Performance of Rapid Evaporative Ionization Mass Spectrometric (REIMS) Bacterial Identification Open
The recently developed automated, high-throughput monopolar REIMS platform is suited for the identification of clinically important microorganisms. Although already comparable to the previously reported bipolar forceps method, optimization…
View article: Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery
Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery Open
View article: Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI)
Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI) Open
This feature article discusses two modern mass spectrometry abbreviations in their clinical applications. Rapid evaporative ionization mass spectrometry (REIMS) is reported as a molecular classification tool useful for spectral features de…
View article: Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida
Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Provides Accurate Direct from Culture Species Identification within the Genus Candida Open
View article: SURG-31. INTRAOPERATIVE MOLECULAR DIAGNOSIS AND SURGICAL GUIDANCE USING iKNIFE REAL-TIME MASS SPECTROMETRY
SURG-31. INTRAOPERATIVE MOLECULAR DIAGNOSIS AND SURGICAL GUIDANCE USING iKNIFE REAL-TIME MASS SPECTROMETRY Open
Mass spectrometry offers a novel dimension-rich modality to characterize brain tumors and guide surgery in real-time. It seamlessly integrates with traditional biopolar forceps to offer a level of tissue analysis never available before to …
View article: A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife
A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife Open
Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were …
View article: SURG-28NEUROSURGICAL INTRAOPERATIVE SPECTROSCOPY: TOWARDS REAL-TIME CNS TUMOUR BIOPSIES
SURG-28NEUROSURGICAL INTRAOPERATIVE SPECTROSCOPY: TOWARDS REAL-TIME CNS TUMOUR BIOPSIES Open
Immediate, real-time accurate tissue characterisation is a crucial unmet need during surgery for the maximal resection of CNS tumours whilst causing minimum damage to surrounding functioning brain tissue. We describe the first ever use of …