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View article: Co-Culture Approaches in Cartilage and Bone Tissue Regeneration
Co-Culture Approaches in Cartilage and Bone Tissue Regeneration Open
Cartilage and bone defects as well as osteoarthritis are prevalent worldwide, affecting individuals across all age groups, from young, active populations to older adults. The standard protocol in cartilage regeneration involves knee replac…
View article: Comparative Analysis of Primary Ovarian Cancer Cells and Established Cell Lines as a New Tool for Studies on Ovarian Cancer Cell Complexity
Comparative Analysis of Primary Ovarian Cancer Cells and Established Cell Lines as a New Tool for Studies on Ovarian Cancer Cell Complexity Open
Primary cancer cells reflect the genetic background and phenotype of a tumor. Immortalized cells with higher proliferation activity have an advantage over primary cells. The aim of the study was to immortalize the primary ovarian cancer (O…
View article: Osteogenic Potential of Human Dental Pulp Stem Cells (hDPSCs) Growing on Poly L-Lactide-Co-Caprolactone and Hyaluronic Acid (HYAFF-11TM) Scaffolds
Osteogenic Potential of Human Dental Pulp Stem Cells (hDPSCs) Growing on Poly L-Lactide-Co-Caprolactone and Hyaluronic Acid (HYAFF-11TM) Scaffolds Open
Bone tissue engineering using different scaffolds is a new therapeutic approach in regenerative medicine. This study explored the osteogenic potential of human dental pulp stem cells (hDPSCs) grown on a hydrolytically modified poly(L-lacti…
View article: The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma
The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy worldwide, with a poor prognosis and limited treatment options. Molecularly targeted therapies for HNSCC are still lacking. However, recent reports provide novel…
View article: Properties of scaffolds as carriers of mesenchymal stem cells for use in bone engineering
Properties of scaffolds as carriers of mesenchymal stem cells for use in bone engineering Open
Tissue engineering has become one of the most studied medical fields and appears to be promising for the regeneration of injured bone tissues. Even though the bone has self-remodeling properties, bone regeneration may be required in some c…
View article: Comparison of biomarker expression in oral lichen planus and oral lichenoid lesions
Comparison of biomarker expression in oral lichen planus and oral lichenoid lesions Open
The findings of this study suggest that the slightly higher protein p53 and HSP90 expression in the OLL group might be caused by the medications used. The slight association between p53 and topo I expression indicates that the cooperation …
View article: Advances in Electrospun Hybrid Nanofibers for Biomedical Applications
Advances in Electrospun Hybrid Nanofibers for Biomedical Applications Open
Electrospun hybrid nanofibers, based on functional agents immobilized in polymeric matrix, possess a unique combination of collective properties. These are beneficial for a wide range of applications, which include theranostics, filtration…
View article: Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold
Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold Open
Poly(l-lactide-co-caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrol…
View article: Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential Open
The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not…
View article: Sonic Hedgehog is a novel prognostic biomarker in patients with oral squamous cell carcinoma
Sonic Hedgehog is a novel prognostic biomarker in patients with oral squamous cell carcinoma Open
Recent studies revealed that Sonic Hedgehog (SHH) signaling pathway plays an important role in initiation and tumor progression in various malignancies, however, its role in oral squamous cell carcinoma (OSCC) remains unclear. The objectiv…
View article: Are human dental pulp stem cells the future of neurodegenerative diseases and nerve injury therapy?*
Are human dental pulp stem cells the future of neurodegenerative diseases and nerve injury therapy?* Open
This review summarizes results from in vitro and in vivo studies which provide evidence that human dental pulp stem cells (hDPSCs) might be a novel treatment strategy for nervous system injuries and neurodegenerative diseases because of th…
View article: Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11)
Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11) Open
This study presents direct 2D and 3D co-culture model of mesenchymal stem cells (MSCs) line with chondrocytes isolated from patients with osteoarthritis (unaffected area). MSCs differentiation into chondrocytes after 14, 17 days was checke…
View article: PDGFRα/HER2 and PDGFRα/p53 Co-expression in Oral Squamous Cell Carcinoma
PDGFRα/HER2 and PDGFRα/p53 Co-expression in Oral Squamous Cell Carcinoma Open
Our study revealed that PDGFRα/HER2 and PDGFRα/p53 co-expression exists in poorly differentiated OSCCs, suggesting that cooperation between these proteins might enhance aggressive behavior of tumor.
View article: The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to KRAS Gene Status
The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to KRAS Gene Status Open
Our results revealed that cooperation between HSP90 and Topo I expression exists in CRCs, independently of KRAS gene status, suggesting that co-expression of both proteins might be considered as a double target on individual tumor cells.
View article: The effectiveness of chemotherapy and electrochemotherapy on ovarian cell lines in vitro
The effectiveness of chemotherapy and electrochemotherapy on ovarian cell lines in vitro Open
The presented study aimed to evaluate in vitro the effectiveness of improvement standard chemotherapy with bleomycin by electroporation in two various ovarian cancer cell lines. Two human ovarian cell lines OvBH-1 and SKOV-3 were used. The…