Julia Newton‐Bishop
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View article: Extracellular Vesicles From a Model of Melanoma Cancer‐Associated Fibroblasts Induce Changes in Brain Microvascular Cells Consistent With Pre‐Metastatic Niche Priming
Extracellular Vesicles From a Model of Melanoma Cancer‐Associated Fibroblasts Induce Changes in Brain Microvascular Cells Consistent With Pre‐Metastatic Niche Priming Open
Malignant melanoma has one of the lowest 5‐year survival rates of any cancer and is characterised by its high invasiveness and metastatic potential, with especially poor outcomes in patients who develop brain metastases. Crosstalk between …
View article: Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis
Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis Open
Half of advanced melanoma patients fail to benefit from immune checkpoint blockade and novel treatments are urgently required. Testing topical medications used in other skin diseases for anti-cancer activity in an immunotherapy-resistant m…
View article: Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming
Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming Open
Malignant melanoma has one of the lowest 5-year survival rates of any cancer, and is recognised for being particularly invasive and metastatic, with the poorest survival outcomes in brain metastases patients. A key characteristic of these …
View article: The microenvironment of ulcerated acral melanoma is characterised by an inflammatory milieu and an enhanced humoral immune response
The microenvironment of ulcerated acral melanoma is characterised by an inflammatory milieu and an enhanced humoral immune response Open
Acral melanoma (AM) is a distinct and understudied subtype of melanoma that is reported to represent the majority of melanoma diagnoses in various Latin American, African and Asian countries. Patients with ulcerated AM diagnoses face a wor…
View article: Therapeutic outcomes and safety of radiofrequency ablation for primary papillary thyroid carcinoma: A game-changing meta-analysis
Therapeutic outcomes and safety of radiofrequency ablation for primary papillary thyroid carcinoma: A game-changing meta-analysis Open
RFA is a safe and effective minimally invasive treatment option for both T1a and T1b PTC, with high tumor disappearance and volume reduction rates and low complication and recurrence rates. The low progression rates in both tumor sizes sug…
View article: The Development and Evaluation of a Convolutional Neural Network for Cutaneous Melanoma Detection in Whole Slide Images
The Development and Evaluation of a Convolutional Neural Network for Cutaneous Melanoma Detection in Whole Slide Images Open
Context.— The current melanoma staging system does not account for 26% of the variance seen in melanoma-specific survival, therefore our ability to predict patient outcome is not fully elucidated. Morphology may be of greater significance …
View article: Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study
Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study Open
This study provides evidence that the effects of GLP-1 receptor agonists may extend beyond their known metabolic and cardioprotective benefits to include neuroprotection, associated with a decreased risk of developing various neurodegenera…
View article: Association of <i>MC1R</i> variants with melanoma risk and interaction with sun exposure: An M‐SKIP project
Association of <i>MC1R</i> variants with melanoma risk and interaction with sun exposure: An M‐SKIP project Open
Natural variation at the melanocortin- 1- receptor (MC1R) locus is associated with increased risk of melanoma. MC1R also is one of the major genes controlling skin pigmentation.
View article: Prognostic significance of a negative PSMA PET/CT in biochemical recurrence of prostate cancer
Prognostic significance of a negative PSMA PET/CT in biochemical recurrence of prostate cancer Open
Background Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is becoming standard of care for men with biochemical recurrence (BCR) of prostate cancer. The implications of a negative PSMA P…
View article: Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma
Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma Open
Peripheral blood transcriptomes from 383 patients with newly diagnosed melanoma were subjected to differential gene expression analysis. The hypotheses were that impaired systemic immunity is associated with poorer prognosis (thicker tumor…
View article: Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma
Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma Open
Multiple clinical trials targeting the gut microbiome are being conducted to optimize treatment outcomes for immune checkpoint blockade (ICB). To improve the success of these interventions, understanding gut microbiome changes during ICB i…
View article: Longitudinal gut microbiome changes in immune checkpoint blockade in advanced melanoma
Longitudinal gut microbiome changes in immune checkpoint blockade in advanced melanoma Open
Multiple clinical trials targeting the gut microbiome are being conducted to optimize treatment outcomes for immune checkpoint blockade (ICB). To improve the success of these interventions, understanding gut microbiome dynamics during ICB …
View article: Surgical excision methods for skin cancer involving the nail unit: A systematic review
Surgical excision methods for skin cancer involving the nail unit: A systematic review Open
Introduction Skin cancer affecting the nail unit is rare but is associated with morbidity, and melanoma has a high mortality rate. The principal treatment is surgical excision and methods can be classified into digit‐sparing surgery or amp…
View article: Surgical excision methods for skin cancer involving the nail unit: a systematic review
Surgical excision methods for skin cancer involving the nail unit: a systematic review Open
Introduction Skin cancer affecting the nail unit is rare but is associated with morbidity, and melanoma has a high mortality rate. The principal treatment is surgical excision and methods can be classified into digit-sparing surgery or amp…
View article: Supplementary Figure S6 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S6 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Loss of GRAMD1B promotes tumor cell invasion in human melanoma cells
View article: Supplementary Figure S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
An in vivo screen identifies metastasis suppressors in melanoma.
View article: Supp Table S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supp Table S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supplementary Table S1. List of genes predictive of metastasis from AVAST-M trial.
View article: Supplementary Figure S2 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S2 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
CRISPR Sequencing of MAS2X tumors.
View article: Supplementary Figure S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
The AVAST-M trial identifies a signature predictive of metastatic relapse
View article: Supplementary Figure S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supp. Fig. S5 shows that GRAMD1B is a metastasis suppressor in human melanoma
View article: Supp Table S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supp Table S1 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supplementary Table S1. List of genes predictive of metastasis from AVAST-M trial.
View article: Supplementary Figure S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supp. Fig. S5 shows that GRAMD1B is a metastasis suppressor in human melanoma
View article: Supp Table S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supp Table S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supplementary Table S5. Normalized Counts of transcripts in GRAMD1B KO and NT cells.
View article: Supplementary Figure S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
An in vivo screen identifies metastasis suppressors in melanoma.
View article: Supplementary Figure S8 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supplementary Figure S8 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Cholesterol overload activates AP-1 via ERK signaling to mediate invasion upon GRAMD1B loss in melanoma.
View article: Supp Table S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supp Table S4 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supp Table S4 has a list of antibodies and other resources
View article: Supp Table S7 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Supp Table S7 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma Open
Supp Table S7: GSEA Analysis