Julia Brunmair
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View article: Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria
Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria Open
Objective Metabolomics measurements of eccrine sweat may provide novel and relevant biomedical information to support predictive, preventive and personalised medicine (3PM). However, only limited data is available regarding metabolic alter…
View article: Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States
Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States Open
Introduction Ulcerative colitis [UC] is a chronic disease with rising incidence and unclear aetiology. Deep molecular phenotyping by multiomics analyses may provide novel insights into disease processes and characteristic features of remis…
View article: Probabilistic quotient’s work and pharmacokinetics’ contribution: countering size effect in metabolic time series measurements
Probabilistic quotient’s work and pharmacokinetics’ contribution: countering size effect in metabolic time series measurements Open
Metabolomic time course analyses of biofluids are highly relevant for clinical diagnostics. However, many sampling methods suffer from unknown sample sizes, commonly known as size effects. This prevents absolute quantification of biomarker…
View article: Yellow Twig (Nauclea orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species
Yellow Twig (Nauclea orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species Open
Comprehensive phytochemical examination from different perspectives using preparative and analytical chromatographic techniques combined with spectroscopic/spectrometric methods of the so-called “yellow twig” Nauclea orientalis (L.) L. (Ru…
View article: Multi-omics empowered deep phenotyping of ulcerative colitis
Multi-omics empowered deep phenotyping of ulcerative colitis Open
Objective Ulcerative colitis (UC) is a chronic disease with rising incidence and unclear etiology. The application of mass spectrometry-based analysis methods shall support the establishment of systemic molecular biomarker signatures provi…
View article: Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients
Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients Open
Background/aims Concerning healthcare approaches, a paradigm change from reactive medicine to predictive approaches, targeted prevention, and personalisation of medical services is highly desirable. This raises demand for biomarker signatu…
View article: Probabilistic quotient’s work & pharmacokinetics’ contribution: countering size effect in metabolic time series measurements
Probabilistic quotient’s work & pharmacokinetics’ contribution: countering size effect in metabolic time series measurements Open
Metabolomic time course analyses of biofluids are highly relevant for clinical diagnostics. However, many sampling methods suffer from unknown sample sizes commonly known as size effects. This prevents absolute quantification of biomarkers…
View article: Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients
Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients Open
Background/Aims One goal of predictive, preventive, and personalised medicine is to improve the prediction and diagnosis of diseases, as well as to monitor therapeutic efficacy and to tailor individualised treatments with as little side ef…
View article: Finger sweat analysis enables short interval metabolic biomonitoring in humans
Finger sweat analysis enables short interval metabolic biomonitoring in humans Open
Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues, which are imp…
View article: Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels
Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels Open
Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ q…
View article: Metabo-tip: a Metabolomics Platform for Lifestyle Monitoring
Metabo-tip: a Metabolomics Platform for Lifestyle Monitoring Open
Exposure to bioactive compounds from nutrition, pharmaceuticals, environmental contaminants or other lifestyle habits may affect the human organism. To gain insight into the effects of these influences, as well as the fundamental biochemic…
View article: Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture
Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture Open
Reproducibility issues regarding in vitro cell culture experiments are related to genetic fluctuations and batch-wise variations of biological materials such as fetal calf serum (FCS). Genome sequencing may control the former, while the la…
View article: Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial
Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial Open
Caffeine is commonly used to combat high sleep pressure on a daily basis. However, interference with sleep–wake regulation could disturb neural homeostasis and insufficient sleep could lead to alterations in human gray matter. Hence, in th…
View article: Finger Sweat Analysis Enables Short Interval Metabolic Biomonitoring in Humans
Finger Sweat Analysis Enables Short Interval Metabolic Biomonitoring in Humans Open
Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues and are imprac…
View article: Eicosanoid content in fetal calf serum accounts for reproducibility challenges in cell culture
Eicosanoid content in fetal calf serum accounts for reproducibility challenges in cell culture Open
Reproducibility issues regarding in vitro cell culture experiments are related to genetic fluctuations and batch-wise variations of biological materials such as fetal calf serum (FCS). Genome sequencing may control the former, while the la…