Julia Catalán
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View article: Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability
Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability Open
Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and…
View article: An integrated approach to assess exposure and early health effects in human populations exposed to micro- and nanoplastics
An integrated approach to assess exposure and early health effects in human populations exposed to micro- and nanoplastics Open
Although cumulative evidence from in vitro and in vivo studies indicates that micro- and nanoplastics (MNPs) can induce toxic effects, and MNPs have been detected in several human fluids and tissues, the consequences of MNP exposure to hum…
View article: Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project
Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project Open
Low-to-moderate Cr(VI) exposure was associated with higher oxidative stress, longer telomeres and epigenetic alterations, changes that previously have been linked to lung cancer risk. This study highlights the molecular impacts of Cr(VI) e…
View article: The SAbyNA platform: a guidance tool to support industry in the implementation of safe- and sustainable-by-design concepts for nanomaterials, processes and nano-enabled products
The SAbyNA platform: a guidance tool to support industry in the implementation of safe- and sustainable-by-design concepts for nanomaterials, processes and nano-enabled products Open
The SAbyNA platform supports value chain actors in developing safe-by-design nano-enabled products early in their development phases. The potential of digital guidance is exemplified in a case study on carbon nanotube-based 3D-printed prod…
View article: In vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics
In vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics Open
Continuous exposure to plastic pollutants may have serious consequences on human health. However, most toxicity assessments focus on non-environmentally relevant particles and rarely investigate long-term effects such as cancer induction. …
View article: Role of Chemical Reduction and Formulation of Graphene Oxide on Its Cytotoxicity towards Human Epithelial Bronchial Cells
Role of Chemical Reduction and Formulation of Graphene Oxide on Its Cytotoxicity towards Human Epithelial Bronchial Cells Open
Graphene-based materials may pose a potential risk for human health due to occupational exposure, mainly by inhalation. This study was carried out on bronchial epithelial 16HBE14o− cells to evaluate the role of chemical reduction and formu…
View article: Impact of physico-chemical properties on the toxicological potential of reduced graphene oxide in human bronchial epithelial cells
Impact of physico-chemical properties on the toxicological potential of reduced graphene oxide in human bronchial epithelial cells Open
The increasing use of graphene-based materials (GBM) requires their safety evaluation, especially in occupational settings. The same physico-chemical (PC) properties that confer GBM extraordinary functionalities may affect the potential to…
View article: Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report
Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report Open
Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. However, the fi…
View article: 61 Evaluation of the Toxicity, Alveolar Cell Accumulation and Clearance of PET and PS Nanoplastics in Mouse Lungs
61 Evaluation of the Toxicity, Alveolar Cell Accumulation and Clearance of PET and PS Nanoplastics in Mouse Lungs Open
Airborne micro and nano-plastics (MNPs) have been detected in both indoor and outdoor settings, raising concerns about potential adverse effects upon inhalation. Yet, their potential pulmonary toxicity has not been studied extensively. Her…
View article: High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels
High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels Open
Introduction Inhalation of nanomaterials may induce inflammation in the lung which if left unresolved can manifest in pulmonary fibrosis. In these processes, alveolar macrophages have an essential role and timely modulation of the macropha…
View article: The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design
The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design Open
The Safe-by-Design (SbD) concept aims to facilitate the development of safer materials/products, safer production, and safer use and end-of-life by performing timely SbD interventions to reduce hazard, exposure, or both. Early hazard scree…
View article: HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium Open
A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus ana…
View article: Effect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils
Effect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils Open
Cellulose nanofibrils (CNFs) have emerged as sustainable options for a wide range of applications. However, the high aspect ratio and biopersistence of CNFs raise concerns about potential health effects. Here, we evaluated the in vivo pulm…
View article: Genotoxicity of Graphene-Based Materials
Genotoxicity of Graphene-Based Materials Open
Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the exist…
View article: Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose
Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose Open
Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with a wide range of applications and increasing presence in the market. Surface charges are introduced during the preparation of NFC to facilitate the defi…
View article: Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping
Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping Open
Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modificatio…
View article: Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice
Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice Open
In this study, two sets of methyl-coated non-porous and mesoporous amorphous silica materials of two target sizes (100 and 300 nm; 10-844 m2/g) were used to investigate the potential role of specific surface area (SSA) and porosity on the …
View article: Genotoxicity and Cytotoxicity of Gold Nanoparticles In Vitro: Role of Surface Functionalization and Particle Size
Genotoxicity and Cytotoxicity of Gold Nanoparticles In Vitro: Role of Surface Functionalization and Particle Size Open
Several studies suggested that gold nanoparticles (NPs) could be genotoxic in vitro and in vivo. However, gold NPs have currently produced present a wide range of sizes and functionalization, which could affect their interactions with the …