Julia E. Crook
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View article: Targeted plasma eQTL and pQTL analyses to identify potential novel biomarkers for Alzheimer's Disease in African Americans
Targeted plasma eQTL and pQTL analyses to identify potential novel biomarkers for Alzheimer's Disease in African Americans Open
Background African Americans (AA) are twice as likely to develop dementia than non‐Hispanic Whites but remain underrepresented in Alzheimer's Disease (AD) research. Recent studies have identified AA specific risk factors for AD. Therefore,…
View article: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis 9119
Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis 9119 Open
Description Amyotrophic lateral sclerosis (ALS), like many neurodegenerative disorders, features cytoplasmic inclusion of proteins, with the most prominent component identified being TDP-43. Neuroinflammation is also apparent in affected t…
View article: Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease
Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease Open
Importance Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic …
View article: Digital pathology analysis reveals TDP‐43 pathology as a strong predictor of glial activation in Alzheimer’s disease
Digital pathology analysis reveals TDP‐43 pathology as a strong predictor of glial activation in Alzheimer’s disease Open
Background Glial activation plays a critical role in Alzheimer’s disease (AD) pathogenesis and is associated with amyloid‐β plaques and neurofibrillary tangles composed of phosphorylated tau (phospho‐tau). With approximately 40%‐60% of AD …
View article: Depression is associated with dementia and accelerated cognitive decline in African Americans
Depression is associated with dementia and accelerated cognitive decline in African Americans Open
Background African Americans (AA) represent 12% of the United States population ≥65 years‐old, but 19% of persons with dementia. Inequalities in social determinants of health may influence access to healthcare resources contributing to inc…
View article: Identification of genes and blood co‐expression networks associated with cerebrovascular neuroimaging phenotypes
Identification of genes and blood co‐expression networks associated with cerebrovascular neuroimaging phenotypes Open
Background A hallmark of Alzheimer’s disease is amyloid‐β (Aβ) deposition in the brain parenchyma as senile plaques which Aß frequently accompanies in the cerebral vasculature as cerebral amyloid angiopathy (CAA). Previous studies demonstr…
View article: Targeted plasma eQTL and pQTL to identify potential novel biomarkers for Alzheimer’s Disease in African Americans
Targeted plasma eQTL and pQTL to identify potential novel biomarkers for Alzheimer’s Disease in African Americans Open
Background Given the overlap of symptoms between Alzheimer’s disease (AD) and other dementias, it is essential to develop widely accessible biomarkers that will ensure an accurate diagnosis of AD to enable its proper treatment. African Ame…
View article: Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy
Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy Open
Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder characterized by cell-type-specific tau lesions in neurons and glia. Prior work uncovered transcriptome changes in human PSP brains, although their cell-spec…
View article: Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old
Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old Open
Background: Dementia, vascular disease, and cancer increase with age, enabling complex comorbid interactions. Understanding vascular and cancer contributions to dementia risk and neuropathology in oldest-old may improve risk modification a…
View article: Trigger Point Injections Followed by Immediate Myofascial Release in the Treatment of Myofascial Pelvic Pain
Trigger Point Injections Followed by Immediate Myofascial Release in the Treatment of Myofascial Pelvic Pain Open
Purpose Pelvic floor physical therapy (PFPT) is first line therapy for treatment of myofascial pelvic pain (MFPP). Pelvic floor trigger point injections (PFTPI) are added if symptoms are refractive to conservative therapy or if patients ex…
View article: Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the <i>post mortem</i> brain
Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the <i>post mortem</i> brain Open
Introduction Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibril…
View article: Comment on wcd-2021-46
Comment on wcd-2021-46 Open
Abstract. Tropical cyclones (TCs) in the Bay of Bengal can be extremely destructive when they make landfall in India and Bangladesh. Accurate prediction of their track and intensity is essential for disaster management. This study evaluate…
View article: Effects of sex and APOE on Parkinson’s Disease-related cognitive decline
Effects of sex and APOE on Parkinson’s Disease-related cognitive decline Open
Male sex and APOE ε4, along with age and lower education level, were associated with poorer cognitive performance among a population of predominantly non-demented PD patients.
View article: Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brain
Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brain Open
Alzheimer’s disease (AD) biomarkers have become increasingly more reliable in predicting AD pathology. While phosphorylated tau fluid biomarkers have been studied for over 20 years, there is a lack of deep characterization of these sites i…
View article: Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment
Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment Open
Objectives: Lifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger compa…
View article: Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease
Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease Open
Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s disease (AD) dementia and is a common finding at autopsy. The APOE ε4 allele and male sex have previously been reported to associate with increas…
View article: Latent trait modeling of tau neuropathology in progressive supranuclear palsy
Latent trait modeling of tau neuropathology in progressive supranuclear palsy Open
Progressive supranuclear palsy (PSP) is the second most common neurodegenerative Parkinsonian disorder after Parkinson’s disease, and is characterized as a primary tauopathy. Leveraging the considerable clinical and neuropathologic heterog…
View article: Yoga Training Impacts Physical Function 12 Months Post Intervention for Care Partners of those with Mild Cognitive Impairment
Yoga Training Impacts Physical Function 12 Months Post Intervention for Care Partners of those with Mild Cognitive Impairment Open
Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our resear…
View article: Comparative Effectiveness of Behavioral Interventions to Prevent or Delay Dementia: One-Year Partner Outcomes
Comparative Effectiveness of Behavioral Interventions to Prevent or Delay Dementia: One-Year Partner Outcomes Open
Our results support the benefits of wellness education and yoga for improving partner's burden, mood, and anxiety at one year. Our findings are the first to provide an exploration of the impact of multicomponent interventions in care partn…
View article: Characterizing the cognitive phenotype of Parkinson’s disease
Characterizing the cognitive phenotype of Parkinson’s disease Open
Background Parkinson’s disease (PD) is a complex neurodegenerative disease in which combinations of motor and non‐motor symptoms result in a wide range of phenotypic presentations and disease progression. Precise characterization of these …
View article: Yoga training impacts physical function 12 months post intervention for care partners of those with mild cognitive impairment
Yoga training impacts physical function 12 months post intervention for care partners of those with mild cognitive impairment Open
Background The American Academy of Neurology Practice Guidelines recommends physical exercise to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory r…
View article: Plasma Biomarkers of Alzheimer’s Disease in African Americans
Plasma Biomarkers of Alzheimer’s Disease in African Americans Open
Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer’s disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. Methods: We e…
View article: Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy
Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy Open
Missense variants ABI3 _rs616338-T and PLCG2 _rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are…